Five flavonoids, 5-hydroxy-(6:7,3′:4′)-di(2,2-dimethylpyrano)flavone 1, carpachromene 2, cycloartocarpesin 3, norartocarpetin 4 and 2′-hydroxy-4,4′,6′- trimethoxychalcone 5, along with three triterpenes, friedelin 6, lupeol 7 and β-sitosterol 8 were isolated for the first time from the leaves of Artocarpus fulvicortex F.M. Jarrett. The structures of these compounds were established by analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison of these with those reported in the literature.
BurkhillIH. (1966) A dictionary of the economic products of the Malay Peninsula, Ministry of Agriculture and Co-operatives, Kuala Lumpur, 2nd. Edn., vol. 1, 249–260.
2.
WhitmoreTC. (1978) Tree flora of Malaya, Longman, Kuala Lumpur, vol. 3, 119–167.
HakimEH, AchmadSA, JuliawatyLD, MakmurL, SyahYM, AimiN, KitajimaM, TakayamaH, GhisalbertiEL. (2006) Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae). Journal of Natural Medicine, 60, 161–184
5.
JamilS, SiratHM, JantanI, AimiN, KitajimaM. (2008) A new prenylated dihydrochalcone from the leaves of Artocarpus lowii. Journal of Natural Medicine, 62, 321–324
6.
MusthapaI, LatipJ, TakayamaH, JuliawatyLD, HakimEH, SyahYM. (2009) Prenylated flavones from Artocarpus lanceifolius and their cytotoxic properties against P-388 cells. Natural Product Communications, 4, 927–930
JantanI, Mohd YasinYH, JamilS, SiratHM, BasarN. (2010) Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood. Journal of Natural Medicine, 64, 365–369
9.
KueteV, AngoPY, FotsoGW, KapcheGDWF, DzoyemJP, WoukingAG, NgadjuiBT, AbegazBM (2011) Antimicrobial activities of the methanol extract and compounds from Artocarpus communis (Moraceae). BMC Complementary and Alternative Medicine, 11, 42–46
10.
JayasingheL, BalasooriyaBAIS, PadminiWC, HaraN, FujimotoY. (2004) Geranyl chalcone derivatives with antifungal and radical scavenging properties from the leaves of Artocarpus nobilis. Phytochemistry, 65, 1287–1290.
11.
WeiBL, WengJR, ChiuPH, HungCF, WangJP, LinCN (2005) Anti-inflammatory flavonoids from Artocarpus heterophyllus and Artocarpus communis. Journal of Agricultural and Food Chemistry, 53, 3867–3871.
12.
HsuC-Lin, ShyuM-H, LinJ-A, YenG-C, FangS-C (2011) Cytotoxic effects of geranyl flavonoid derivatives from the fruit of Artocarpus communis in SK-Hep-1 human hepatocellular carcinoma cells. Food Chemistry, 127, 127–134.
13.
ZhengZP, ChengK-W, ToJT-K, LiH, WangM (2008) Isolation of tyrosinase Inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent. Molecular Nutrition and Food Research, 52, 1530–1538
HanoY, ItohN, HanaokaA, NomuraT (1995) Paratocarpins F-L, seven new isoprenoid- substituted flavonoids from Paratocarpus venenosa Zoll. Heterocycles, 41, 2313–2326.
16.
SeidelV, BailleuF, WatermanPG. (2000) (Rel)-1b,2a-di-(2,4-dihydroxy-6-methoxybenzoyl)-3b,4a-di-(4-methoxyphenyl)-cyclobutane and other flavonoids from the aerial parts of Goniothalamus gardneri and Goniothalamus thwaitesii. Phytochemistry, 55, 439–446.
MonacheDM, RosaMCD, ScurriaR, VitaliA, CuteriA, MonacelliB, PasquaG, BottaB (1995) Comparison between metabolite productions in cell culture and in whole plant of Maclura pomifera. Phytochemistry, 39, 575–580.
20.
HakimEH, JuliawatyLD, SyahYM, AchmadSA (2005) Molecular diversity of Artocarpus champeden (Moraceae): A species endemic to Indonesia. Molecular Diversity, 9, 149–158
SuB-N, CuendetM, HawthorneME, KardonoLBS, RiswanS, FongHHS, MehtaRG, PezzutoJM, KinghornAD (2002) Constituents of the barks and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity. Journal of Natural Products, 65, 163–169.
23.
AgarwalRB, RangariVD (2003) Antiinflammatory and antiarthritic activities of lupeol isolated from Strobilanthus callosus and Strobilanthus ixiocephala Roots. Indian Journal of Pharmacology, 35, 384–387.
24.
QueirogaCL, SilvaGF, DiasPC, PossentiA, CarvalhoJE (2000) Evaluation on the antiulcerogenic activity of friedelin-3ß-ol and friedelin isolated from Maytenus ilicifolia (Celastraceae). Journal of Ethnopharmacology, 72, 465–468.
25.
DhakalRC, RajbhandariM, KalauniSK, AwaleS, GewaliMB (2008) Phytochemical constituents of the barks of Vitex negundo L. Journal of Nepal Chemical Society, 23, 89–92.
