In the search for antiproliferative compounds against human cancer cells (A549, SK-OV-3, SK-MEL-2, XF498, HCT15), it was found that the chloroform extracts obtained from the whole plant of Carpesium rosulatum Miq. (Compositae) exhibited significant cytotoxic activity. Two sesquiterpene lactones, CT-1 (2α,5-epoxy-5,10-dihydroxy-6-angeloyloxy-9β-isobutyloxy-germacran-8α,12-olide), and CT-2 (2β,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide) were isolated from the whole plant. CT-2 showed the most potent cytotoxicity with an IC50 value of 7.88 μM against SK-MEL-2.
YookC.S. (1981) Medicinal plants of Korea.Jinmyeong Publishing Co, Seoul, p 392.
2.
GaoX., LinC.J., JiaZ.J. (2002) Cytotoxic germacranolides and acyclic diterpenoids from the seeds of Carpesium triste. Journal of Natural Products, 70, 830–834.
KimD.K., BaekN.I., ChoiS.U., LeeC.O., LeeK.R., ZeeO.P. (1996) Four new cytotoxic germacranolides from Carpesium divaricatum. Journal of Natural Products, 60, 1199–1202.
5.
MaruyamaM., ShibataF. (1975) Stereochemistry of granilin isolated from Carpesium abrotanoides. Phytochemistry, 14, 2247–2248.
6.
KimM.R., HwangB.Y., JeongE.S., LeeY.M., YooH.S., ChungY.B., HongJ.T., MoonD.C. (2007) Cytotoxic germacranolide sesquiterpene lactones from Carpesium triste var. manshuricum. Archives of Pharmacal Research, 30, 556–560.
ZeeO.P., KimD.K., LeeK.R. (1998) Thymol derivatives from Carpesium divaricatum. Archives of Pharmacal Research, 21, 618–620.
9.
MasaoM. (1990) Sesquiterpene lactones from Carpesium divaricatum. Phytochemistry, 29, 547–550.
10.
LiZ., MengZ., SayeedA., ShalabyR., LjungB.M., DairkeeS.H. (2002) Genome wide alleotyping of a new in vitro model system reveals early events in breast cancer progression. Cancer Research, 62, 5980–5987.
11.
SkehanP., StorengR., ScudieroD. (1990) New colorimetric cytotoxicity assay for anticancer-drug screening. Journal of the National Cancer Institute, 82, 1107–1112.
