A new cubitane-based diterpenoid, triangulene C (1), was isolated from the soft coral Sinularia triangula and its structure was elucidated on the basis of spectroscopic data. Compound 1 was not cytotoxic (IC50 >20 μg/mL) toward the four human cancer cell lines tested (HL60, MDA-MB-231, HCT-116 and DLD-1).
LuMC, LeeNL, TsengSW, SuJH. (2011) Sinutriangulin A, a novel diterpenoid from the soft coral Sinularia triangula. Tetrahedron Letters, 52, 5869–5871.
2.
SuJH, WenZH. (2011) Bioactive cembrane-based diterpenoids from the soft coral Sinularia triangula. Marine Drugs, 9, 944–951.
3.
LookSA, FenicalW, Qi-taiZ, ClardyJ. (1984) Calyculones, new cubitane diterpenoids from the Caribbean octocoral Eunicea calyculata. Journal of Organic Chemistry, 49, 1417–1423.
4.
AllingerNL. (1977) Conformational analysis. 130. MM2. A hydrocarbon force field utilizing V1 and V2 torsional terms. Journal of the American Chemical Society, 99, 8127–8134.
5.
AlleyMC, ScudieroDA, MonksA, HurseyML, CzerwinskiMJ, FineDL, AbbottBJ, MayoJG, ShoemakerRH, BoydMR. (1988) Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Research, 48, 589–601.
6.
ScudieroDA, ShoemakerRH, PaullKD, MonksA, TierneyS, NofzigerTH, CurrensMJ, SeniffD, BoydMR. (1988) Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Research, 48, 4827–4833.