Four new eremophilane-type sesquiterpenes, culcitiolides A-D, were isolated from the stem of Senecio culcitioides Sch. Bip (Asteraceae). Their structures were established by detailed 2D NMR spectroscopic and single-crystal X-ray experiments. These compounds were assessed for inhibitory activity against nuclear factor κB (NF-κB). Culcitiolides C and D at 20 μM showed 97 and 100% inhibition of NF-κB activity, respectively.
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Crystallographic data for 1 have been deposited at the Cambridge Crystallographic Data Center under the reference numbers CCDC 853792 for a mixture of 1 and 297. Copies of the data can be obtained, free of charge, on application to the Director, CCDC, 12 Union Road, Cambridge CB2, 1EZ, UK.
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