Phomosine K (1), a new phomosine derivative, has been isolated from Phomopsis sp., in addition to six known compounds: phomosine A (2), phenylalanine amide (3), 2-hydroxymethyl-4β,5α,6β-trihydroxycyclohex-2-en (4), (-)-phyllostine (5), (+)-epiepoxydon (6), and (+)-epoxydon monoacetate (7). Preliminary studies showed that compound 1 had strong antibacterial activity, while compounds 4-7 showed good antifungal, antibacterial, and algicidal properties, except compounds 4 and 6, which lacked antifungal activity.
KrohnK, UllahZ, HussainH, FloerkeU, SchulzB, DraegerS, PescitelliG, SalvodoriP, AntusS, KurtanT. (2007) Massarilactones E-G, new metabolites from the endophytic fungus Coniothyrium sp., associated with the plant Artimisia maritima. Chiralty, 19, 464–470;
2.
DaiJ, HussainH, DrägerS, SchulzB, KurtánT, PescitelliG, FlörkeU, KrohnK. (2010) Metabolites from the fungus Phoma sp. 7210, associated with Aizoon canariense. Natural Product Communications, 5, 1175–1180.
3.
KrohnK, MichelA, RoemerE, FlörkeU, AustHJDraegerS, SchulzB, WrayV. (1995) Biologically active metabolites from fungi; three new biaryl ethers from Phomopsis sp. Natural Product Letters, 9, 309–314.
4.
RamallalRMLizR, GotorV. (2010) Enantiopure trans-3-arylaziridine-2-carboxamides: Preparation by bacterial hydrolysis and ring-openings toward enantiopure, unnatural amino acids. Journal of Organic Chemistry, 75, 6614–6624.
5.
SmetaninaOFKalinovskiiAIKhudyakovYVMoiseenkoOPPivkinMVMenzorovaNISibirtsevYTKuznetsovaTA. (2005) Metabolites of the marine fungus Asperigillus varians KMM 4630. Chemistry of Natural Compounds, 41, 243–244.
6.
MehtaG, IslamK. (2004) Enantioselective total synthesis of epoxyquinone natural products (-)-phyllostine, (+)-epoxydon, (+)-epiepoxydon and (-)-panepophenanthrin: access to versatile chiral building blocks through enzymatic kinetic resolution. Tetrahedron Letters, 45, 7683–7687;
7.
KlemkeC, KehrausS, WrightADKönigGM. (2004) New secondary metabolites from the marine endophytic fungus Apiospora montagnei. Journal of Natural Products, 67, 1058–1063.
8.
SchulzB, SuckerJ, AustHJKrohnK, LudewigK, JonesPGDoeringD. (1995) Biologically active secondary metabolites of endophytic Pezicula species. Mycological Research, 99, 1007–1015;
9.
HöllerU, WrightADMattheeGFKönigGMDraegerS, AustHJSchulzB. (2000) Fungi from marine sponges: diversity, biological activity and secondary metabolites. Mycological Research, 104, 1354-1365;
10.
StewartAMMeierK, SchulzB, SteinertM, SniderBB. (2010) Synthesis and biological evaluation of (+)-dinemasone C and analogues. Journal of Organic Chemistry, 75, 6057–6060.
