Bioassay guided fractionation of the ethanol extract of a new endemic species of the genus Astrotrichilia led to the isolation of the new antiproliferative 3-(4′-hydroxy-2′,3′-dihydroprenyl)-4,6-dimethoxy-5-methylcoumarin, named astrotricoumarin (8) with an IC50 value of 6.8 μM against the A2780 cell line. The structure of compound 8 was elucidated on the basis of its physical and spectroscopic data, including extensive 1D- and 2D-NMR analysis.
Biodiversity Conservation and Drug Discovery in Madagascar, Part 48. For Part 47, see PanE, CaoS, BrodiePJ, CallmanderM, RandrianaivoR, RakotonandrasanaS, RakotobeE, RasamisonVE, TenDykeK, ShenY, SuhEM, KingstonDGI. (2011) Isolation and synthesis of antiproliferative eupolauridine alkaloids of Ambavia gerrardii from the Madagascar dry forest. Journal of Natural Products, 74, 1169–1174.
2.
MabberleyDJ. (1997) The Plant-Book. A Portable Dictionary of the Higher Plants.Cambridge, England, Cambridge University Press.
OkogunJI, EnyenihiVU, EkongDEU. (1978) Spectral studies on coumarins and determination of constitution of ekersenin by total synthesis. Tetrahedron, 34, 1221–1224.
13.
CaoS, BrodiePJ, MillerJS, RandrianaivoR, RatovosonF, BirkinshawC, AndriantsiferanaR, RasamisonVE, KingstonDGI. (2007) Antiproliferative xanthones of Terminalia calcicola from the Madagascar rain forest. Journal of Natural Products, 70, 679–681.
14.
LouieKG, BehrensBC, KinsellaTJ, HamiltonTC, GrotzingerKR, McKoyWM, WinkerMA, OzolsRF. (1985) Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine. Cancer Research, 45, 2110–2115.
