A new phenolic derivative, 4-methoxyphenol 1-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (1), has been identified together with uncommon 3,4-dimethoxyphenol 1-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (2) and 3-hydroxy, 4-methoxyphenol 1-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (3) from the leaves of Martinella obovata (Kunth) Bureau & K. Schum., an Honduran species used in folk medicine for the treatment of eyes diseases. Verbascoside, isoverbascoside, leucoceptoside A, vitexin, isovitexin, luteolin 8-C-β-D-glucopiranoside and spireoside were also found. All structures were elucidated on the basis of mass spectrometry and 2D NMR techniques.