The root bark of Pongamia pinnata Pierre (syn P. glabra Vent.) has afforded a new biflavonyloxymethane, pongabiflavone, along with a known furanoflavone, 3-methoxy-(7, 8, 2″, 3″) furanoflavone. The structure of this new compound was elucidated from extensive spectral studies, including 2D-NMR spectroscopic experiments. The antioxidant, radical quenching activity- superoxide and nitric oxide quenching activities of both pongabiflavone and previously isolated karanjabiflavone have been evaluated which can be a key to cure Psoriasis.
FolmerF., JasparsM., DicatoM., DiederichM. (2008) Marine natural products as targeted modulators of the transcription factor NF-kappaB. Biochemical Pharmacology, 75, 603–617.
2.
BremnerP., HeinrichM. (2002) Natural products as targeted modulators of the nuclear factor-kappaB pathway. Journal of Pharmacy and Pharmacology, 54, 453–472.
3.
SiriwatanametanonN., FiebichB.L., EfferthT., PrietoJ.M., HeinrichM. (2010) Traditionally used Thai medicinal plants: In vitro antiinflammatory, anticancer and antioxidant activities. Journal of Ethnopharmacology, 130, 196–207.
4.
TISTR.Centre of Knowledge, Institute of Scientific Research and Technology of Thailand. (2010) [internet]. TISTR-Medicinal Plants Database [accessed 16 Jan 2010] Available from http://203.185.68.209/.
LemmenR., BunyapraphatsaraN. (2003) Plant resources of south-east Asia, Medicinal and Poisonous Plants 3.Backhuys Publishers, Leiden, The Netherlands.
7.
WoradulayapinijW., SoonthornchareonnonN., WiwatC. (2005) In vitro HIV type 1 reverse transcriptase inhibitory activities of Thai medicinal plants and Canna indica L. rhizomes. Journal of Ethnopharmacology, 101, 84–89.
8.
DaiN., YuY., RenT., WuJ., JiangY., ShenL., ZhangJ. (2007) Gynura root induces hepatic veno-occlusive disease: a case report and review of the literature. World Journal of Gastroenterology, 13, 1628–1631.
9.
ChenM., CaiJ., DuQ. (2007) Hepatic veno-occlusive disease associated with the use of Gynura segetum. European Journal of Internal Medicine, 18, 609.
10.
BorkP.M., SchmitzM.L., KuhntM., EscherC., HeinrichM. (1997) Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-[kappa]B. FEBS Letters, 402, 85–90.
11.
HouW., LinR., LeeT., HuangY., HsuF., LeeM. (2005) The phenolic constituents and free radical scavenging activities of Gynura formosana Kiamnra. Journal of the Science of Food and Agriculture, 85, 615–621.
12.
EndringerD.C., PezzutoJ.M., BragaF.C. (2009) NF-[kappa]B inhibitory activity of cyclitols isolated from Hancornia speciosa. Phytomedicine, 16, 1064–1069.
13.
HungT.M., NaM., ThuongP.T., SuN.D., SokD., SongK.S., SeongY.H., BaeK. (2006) Antioxidant activity of caffeoyl quinic acid derivatives from the roots of Dipsacus asper Wall. Journal of Ethnopharmacology, 108, 188–192.
14.
GóngoraL., GinerR.M., MáñezS., del Carmen RecioM., SchinellaG., RíosJ.L. (2002) Effects of caffeoyl conjugates of isoprenyl-hydroquinone glucoside and quinic acid on leukocyte function. Life Sciences, 71, 2995–3004.
15.
GonthierM., VernyM., BessonC., RemesyC., ScalbertA. (2003) Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. Journal of Nutrition, 133, 1853–1859.
16.
WuL. (2007) Effect of chlorogenic acid on antioxidant activity of Flos Lonicerae extracts. Journal of Zhejiang University - Science B, 8, 673–679.
17.
FengR., LuY., BowmanL.L., QianY., CastranovaV., DingM. (2005) Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. Journal of Biological Chemistry, 280, 27888–27895.
18.
ShanJ., FuJ., ZhaoZ., KongX., HuangH., LuoL., YinZ. (2009) Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK/AP-1 activation. International Immunopharmacology, 9, 1042–1048.
19.
MattocksA.R., JukesR. (1987) Improved field tests for toxic pyrrolizidine alkaloids. Journal of Natural Products, 50, 161–166.
20.
VallejoJ., PeralD., GemioP., CarrascoM., HeinrichM., Pardo-de-SantayanaM. (2009) Atractylis gummifera and Centaurea ornata in the Province of Badajoz (Extremadura, Spain)–Ethnopharmacological importance and toxicological risk. Journal of Ethnopharmacology, 126, 366–370.
21.
BremnerP., RiveraD., CalzadoM., ObónC., InocencioC., BeckwithC., FiebichB., MuñozE., HeinrichM. (2009) Assessing medicinal plants from South-Eastern Spain for potential anti-inflammatory effects targeting nuclear factor-Kappa B and other proinflammatory mediators. Journal of Ethnopharmacology, 124, 295–305.
22.
KazumaK., NodaN., SuzukiM. (2003) Malonylated flavonol glycosides from the petals of Clitoria ternatea. Phytochemistry, 62, 229–237.
23.
ArbiserJ.L., LiX., HossainC.F., NagleD.G., SmithD.M., MillerP., GovindarajanB., DiCarloJ., Landis-PiwowarK.R., DouQ.P. (2005) Naturally occurring proteasome inhibitors from mate tea (Ilex paraguayensis) serve as models for topical proteasome inhibitors. Journal of Investigative Dermatology, 125, 207–212.
24.
WangY., LiuB. (2007) Preparative isolation and purification of dicaffeoylquinic acids from the Ainsliaea fragrans Champ by highspeed counter-current chromatography. Phytochemical Analysis, 18, 436–440.
MosmannT. (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55–63.
27.
MroczekT., Ndjoko-IosetK., GlowniakK., Mietkiewicz-CapalaA., HostettmannK. (2006) Investigation of Symphytum cordatum alkaloids by liquid-liquid partitioning, thin-layer chromatography and liquid chromatography-ion-trap mass spectrometry. Analytica Chimica Acta, 566, 157–166.
