FischerN.H., OlivierE.J., FischerH.D. (1979) The biogenesis and chemistry of sesquiterpene lactones, in Progress in the Chemistry of Organic Natural Products, Vol. 38, HerzW., GriesebachH., KirbyG.W. (Eds) Springer, Wien, 47–390.
StanevaJ.D., TodorovaM.N., EvstatievaL.N. (2008) Sesquiterpene lactones as chemotaxonomic markers in genus Anthemis. Phytochemistry, 69, 607–618.
4.
ZidornC. (2008) Sesquiterpene lactones and their precursors as chemosystematic markers in the tribe Cichorieae of the Asteraceae. Phytochemistry, 69, 2270–2296.
5.
HeroutV. (1966) Sesquiterpene lactones: new taxonomic characteristic of the Compositae. Planta Medica, Suppl., 97–106.
6.
HolubM., BudesinskyM. (1986) Sesquiterpene lactones of the umbelliferae. Phytochemistry, 25, 2015–2026.
AzarkenR., GuerraF.M., Moreno-DoradoF.J., JorgeZ.D., MassanetG.M. (2008) Substituent effects in the transannular cyclizations of germacranes. Synthesis of 6-epi-costunolide and five natural steiractinolides. Tetrahedron, 64, 10896–10905.
10.
RoblesM., AregullinM., WestJ., RodriguezE. (1995) Recent studies on the zoopharmacognosy, pharmacology and neurotoxicology of sesquiterpene lactones. Planta Medica, 61, 199–203.
11.
PicmanA.K. (1986) Biological activities of sesquiterpene lactones. Biochemical Systematics and Ecology, 14, 255–281.
12.
SeamanF.C. (1982) Sesquiterpene lactones as taxonomic characters in the Asteraceae. Botanical Review, 48, 121–594.
13.
MarlesR.J., Pazos-SanouL., CompadreC.M., PezzutoJ.M., BloszykE., ArnasonJ.T. (1995) Sesquiterpene lactones revisited: recent developments in the assessment of biological activities and structure relationships. Recent Advances in Phytochemistry, 29, 333–356.
Brogger ChristensenS., RasmussenU., ChristophersenC. (1980) Thapsigargin, constitution of sesquiterpene lactone histamine liberator from Thapsia garganica. Tetrahedron Letters, 21, 3829–3830.
16.
ChristensenS.B., LarsenI.K., RasmussenU., ChristophersenC. (1982) Thapsigargin and thapsigargicin, two histamine liberating sesquiterpene lactones from Thapsia garganica. X-ray analysis of the 7,11-epoxide of thapsigargin. Journal of Organic Chemistry, 47, 649–652.
17.
PedersenO., ChristophersenC., BrehmL., ChristensenS.B. (1985) Analogs of the histamine liberating dihydroxysesquiterpene lactone thapsigargin. Synthesis, X-ray analysis and chemistry. Acta Chemica Scandinavica, Ser. B, B39, 375–390.
18.
ChristensenS.B., NorupE. (1985) Absolute configurations of the histamine liberating sesquiterpene lactones thapsigargin and trilobolide. Tetrahedron Letters, 26, 107–110.
19.
JakobsenC.M., DenmeadeS.R., IsaacsJ.T., GadyA., OlsenC.E., ChristensenS.B. (2001) Design, synthesis, and pharmacological evaluation of thapsigargin analogues for targeting apoptosis to prostatic cancer cells. Journal of Medicinal Chemistry, 44, 4696–4703.
20.
DirschV.M., StuppnerH., VollmarA.M. (2001) Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis. Planta Medica, 67, 557–559.
21.
ZhangS., WonY., OngC., ShenH. (2005) Anticancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms. Current Medicinal Chemistry-Anti-Cancer Agents, 5, 239–249.
22.
ThastrupO., CullenP.J., DrobakB.K., HanleyM.R., DawsonA.P. (1990) Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2+-ATPase. Proceedings of the National Academy of Sciences, 87, 2466–2470.
23.
LyttonJ., WestlinM., HanleyM.R. (1991) Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. Journal of Biological Chemistry, 266, 17067–17071.
24.
ThastrupO., DawsonA.P., ScharffO., FoderB., CullenP.J., DrobakB.K., BjerrumP.J., ChristensenS.B., HanleyM.R. (1994) Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. Agents Actions, 43, 187–193.
25.
TreimanM., CaspersenC., ChristensenS.B. (1998) A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Trends in Pharmacological Sciences, 19, 131–135.
26.
SøhoelH., Lund JensenA.M., MollerJ.V., NissenP., DenmeadeS.R., IsaacsJ.T., OlsenC.E., ChristensenS.B. (2006) Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells. Bioorganic and Medicinal Chemistry, 14, 2810–2815.
27.
ChristensenS.B., AndersenA., KromannH., TreimanM., TombalB., DenmeadeS., IsaacsJ.T. (1999) Thapsigargin analogs for targeting programmed death of androgen-independent prostate cancer cells. Bioorganic and Medicinal Chemistry, 7, 1273–1280.
28.
ChristensenS.B., SkytteD.M., DenmeadeS.R., DionneC., MollerJ.V., NissenP., IsaacsJ.T. (2009) A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells. Anti-Cancer Agents in Medicinal Chemistry, 9, 276–294.
29.
HeathcockC.H. (1973) Total synthesis of sesquiterpenes, in Total synthesis of natural products, Vol. 2, ApSimonJ. (Ed) John Wiley & Sons, Inc., Hoboken, NJ, USA.
30.
HeathcockC.H., GrahamS.L., PirrungM.C., PlavacF., WhiteC.T. (1982) Total synthesis of sesquiterpenes, 1970-79, in Total synthesis of natural products, Vol. 5, ApSimonJ. (Ed) John Wiley & Sons, Inc., Hoboken, NJ, USA.
31.
GoldsmithD., PirrungM.C., MoreheadA.T. (Eds) (1997) A sesquidecade of sesquiterpenes: total synthesis, 1980-1994. Part A: acyclic and monocyclic sesquiterpenes, in Total synthesis of natural products, Vol. 10, John Wiley & Sons, Hoboken, NJ, USA.
32.
GoldsmithD., PirrungM.C., MoreheadA.T., YoungB.G. (Eds) (1999) A sesquidecade of sesquiterpenes: total synthesis, 1980-1994. Part B: bicyclic and tricyclic sesquiterpenes, in Total synthesis of natural products, Vol. 11, John Wiley & Sons, Hoboken, NJ, USA.
33.
MaciasF.A., AguilarJ.M., MolinilloJ.M., MassanetG.M., FronczekF.R. (1994) Studies on the stereostructure of eudesmanolides from Umbelliferae: synthesis of 11β-angeloyloxy-α-santonin. Tetrahedron, 50, 5439–5450.
34.
KametaniT., NemotoH., FukumotoF. (1974) New synthetic method for the key intermediate of the eudesmane class of sesquiterpenes through furan derivatives. Heterocycles, 2, 639–643.
35.
Moreno-DoradoF.J., GuerraF.M., AladroF.J., BustamanteJ.M., JorgeZ.D., MassanetG.M. (1999) An easy route to 11-hydroxy-eudesmanolides. Synthesis of (±) decipienin A. Tetrahedron, 55, 6997–7010.
36.
Moreno-DoradoF.J., GuerraF.M., AladroF.J., BustamanteJ.M., JorgeZ.D., MassanetG.M. (2000) Synthesis of (±)-11 α-hydroxy-3-oxo-6aH,7aH,10βMe-eudesman-1,2-4,5-dien-6,12-olide. Journal of Natural Products, 63, 934–938.
37.
MaciasF.A., AguilarJ.M., MolinilloJ.M., Rodriguez-LuisF., ColladoI.G., MassanetG.M., FronczekF.R. (2000) Studies on the stereostructure of eudesmanolides from Umbelliferae: Total synthesis of (+)-decipienin A. Tetrahedron, 56, 3409–3414.
38.
AladroF.J., GuerraF.M., Moreno-DoradoF.J., BustamanteJ.M., JorgeZ.D., MassanetG.M. (2001) Enantioselective synthesis of (+)-decipienin A. Tetrahedron, 57, 2171–2178.
39.
RasmussenU., BrooggerC.S., SandbergF. (1978) Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L. Acta Pharmaceutica Suecica, 15, 133–140.
40.
OliverS.F., HögenauerK., SimicO., AntonelloA., SmithM.D., LeyS.V. (2003) A route to the thapsigargins from (S)-carvone providing a substrate-controlled total synthesis of trilobolide, nortrilobolide, and thapsivillosin F. Angewandte Chemie, International Edition, 42, 5996–6000.
41.
LeyS.V., AntonelloA., BalskusE.P., BoothD.T., ChristensenS.B., CleatorE., GoldH., HögenauerK., HüngerU., MyersR.M., OliverS.F., SimicO., SmithM.D., SøhoelH., WoolfordA.J.A. (2004) Synthesis of the thapsigargins. Proceedings of the National Academy of Sciences, 101, 12073–12078.
42.
BallM., AndrewsS.P., WierschemF., CleatorE., SmithM.D., LeyS.V. (2007) Total synthesis of thapsigargin, a potent SERCA pump inhibitor. Organic Letters, 9, 663–666.
43.
AndrewsS.P., BallM., WierschemF., CleatorE., OliverS., HögenauerK., SimicO., AntonelloA., HüngerU., SmithM.D., LeyS.V. (2007) Total synthesis of five thapsigargins: Guaianolide natural products exhibiting sub-nanomolar SERCA inhibition. Chemistry - A European Journal, 13, 5688–5712.
44.
ManzanoF.L., GuerraF.M., Moreno-DoradoF.J., JorgeZ.D., MassanetG.M. (2006) Toward the synthesis of thapsigargin: Enantioselective synthesis of 7,11-dihydroxyguaianolides. Organic Letters, 8, 2879–2882.