Two new lupane type saponins, along with one known saponin were isolated from leaves of Oplopanax horridus (Devil's Club). The structures of the two new compounds were elucidated as 3α-hydroxy-lup-20(29)-ene-23, 28-dioic acid-3-O-β-D-glucopyranoside (2) and 24-nor-3-oxo-lup-20(29)-en-28-oic acid-28-O-α-L-rhamnopyranosyl(1″′→4′)-β-D-glucopyranosyl(1″→6′)-β-D-glucopyranoside (3) on the basis of spectroscopic analysis and chemical evidence. The known compound was identified as 3α-hydroxy-lup-20(29)-ene-23, 28-dioic acid (1) by comparison of its spectral data with those reported. Compound 1 was isolated for the first time from the title plant.
TrevorCL, KristinaS, NancyJT. (2004) Devil's club (Oplopanax horridus): An ethnobotanic review. Herbal Gram, American Botanical Council, 62, 33–48.
2.
McCutcheonAR, EllisSM, HancockREW, TowersGHN. (1994) Antifungal screening of medical plants of the British Columbia native peoples. Journal of Ethnopharmacology, 44, 157–169.
3.
McCutchenAR, RobersTE, GibbonsE, EllisSM, BabiukLA, HancockREW, TowersGHW. (1995) Antiviral screening of British Columbia medicinal plants. Journal of Ethnopharmacology, 49, 101–110.
4.
KobaisyM, AbramowskiZ, LermerL, SaxenaG, HancockREW, TowersGHN. (1997) Antimycobacterial polyynes of Devil's club (Oplopanax horridus), a North American native medicinal plant. Journal of Natural Products, 60, 1210–1213.
5.
TaiJ, CheungS, CheahS, ChanE, HasmanD. (2006) In vitro anti-proliferative and antioxidant studies on Devil's club Oplopanax horridus. Journal of Ethnopharmacology, 108, 228–235.
6.
InuiT, WangY, DengS, SmithDC, FranzblauSG, PauliGF. (2007) Counter-current chromatography based analysis of synergy in an antituberculosis ethnobotanical. Journal of Chromatography A, 1151, 211–215.
7.
DouDQ, HuXY, ZhaoYR, KangTG, LiuFY, KuangHX, SmithDC. (2009) Studies on the anti-psoriasis constituents of Oplopanax elatus Nakai. Natural Product Research, 23, 334–332.
8.
ZhaoYR, KangTG, DouDQ, ZhangF, WangSQ. (2008) Study on the HPLC fingerprints of Oplopanax horridus and the comparision of constituents between O. hurridus and O. elatus Nakai. Lishizhen Medicine and Materia Medica Research, 19, 546–548.
9.
ZhaoYR, KangTG, DouDQ, SmithDC. (2008) Study on chemical constituents of volatile oil from stem bark of O. horridus by GC—MS. Journal of LiaoNing University of TCM, 10, 114–115.
10.
LiMo, DouDQ, SmithDC. (2009) Study on chemical constituents of volatiIe oil from leaves of O. horridus by GC-MS. Modern Chinese Medicine, 11, 24–26.
11.
LischewskiTM, PhietHV, SungTV, SchmidtJ, AdamG. (1985) Two 24-nortriterpenoid carboxylic acids from Acanthopanax trifoliatus. Phytochemistry, 24, 2355–2357.
