Three known iridoid glycosides, antirrhide (1), antirrhinoside (2), and 5-O-β-allosylantirrhinoside (3), and two known flavone glycosides, linariin (4″′-O-acetylpectolinarin) (4) and linarin (acacetin-7-O-β-D-rutinoside) (5) were isolated from Linaria kurdica Boiss & Hohen. subsp. eriocalyx The structures of the isolated compounds were established from spectroscopic evidence. Compounds 1-3 showed high inhibitory potential against α-glucosidase.
DavisPH. (1978) Flora of Turkey and the East Aegean Islands Vol. 6, University Press, Edinburgh, 654–672.
2.
KitagawaI, TaniT, AkitaK, YosiokaI. (1973) On the constituents of Linaria japonica MIQ. I. The structure of linarioside, a new chlorinated iridoid glucoside and identification of two related glucosides. Chemical & Pharmaceutical Bulletin, 21, 1978–1987.
3.
ErcilD, SakarMK, Del OlmoE, SanFeliciano A. (2004) Chemical constituents of Linaria aucheri. Turkish Journal of Chemistry, 28, 133–139.
4.
PieroniA, QuaveCL. (2005) Traditional pharmacopoeias and medicines among Albanians and Italians in southern Italy: A comparison. Journal of Ethnopharmacology, 101, 258–270.
5.
ChengM, LiQ, LinB, ShaY, RenJ, HeY, WangQ, HuaH, RuudK. (2006) Assignment of the absolute configuration of (-)-linarinic acid by theoretical calculation and asymmetric total synthesis. Tetrahedron: Asymmetry, 17, 179–183.
6.
OtsukaH. (1992) Isolation of isolinariins A and B, new flavonoid glycosides from Linaria japonica. Journal of Natural Products, 55, 1252–1255.
7.
LoizzoMR, TundisR, MenichiniF, BonesiM, StattiGA, DeguinB, TillequinF, MenichiniF, HoughtonPJ. (2007) Acetylcholinesterase inhibition by extracts and isolated flavones from Linaria reflexa Desf. (Scrophulariaceae). Natural Product Communications, 2, 759–763.
8.
OtsukaH. (1994) Linarionosides A–C and acyclic monoterpene diglucosides from Linaria japonica. Phytochemistry, 37, 461–465.
AhmadVU, KousarF, ZubairM, KhanA, AliMS, ChoudharyMI, SenerB. (2006) A new iridoid glycoside from Linaria genestifolia. Fitoterapia, 77, 12–14.
11.
HuaH, ChengM, LiX, PeiY. (2002). A new pyrroloquinazoline alkaloid from Linaria vulgaris. Chemical & Pharmaceutical Bulletin, 50, 1393–1394.
12.
GordalizaM, Miguel del CorrallJM, PuenteML, Garcia-GralvalosMD, San FelicianoA. (1997) Cytotoxic activity of neoclerodane diterpenoids. Bioorganic & Medicinal Chemistry Letters, 7, 1649–1654.
13.
OtsukaH. (1993) Phenylethanoids from Linaria japonica. Phytochemistry, 32, 979–981.
14.
TundisR, DeguinB, LoizzoMR, BonesiM, StattiGA, TillequinF, MenichiniF. (2005) Potential antitumor agents: Flavones and their derivatives from Linaria reflexa Desf. Bioorganic & Medicinal Chemistry Letters, 15, 4757–4760.
15.
SerafiniM, PiccinA, StanzioneA, PetittoV, NicolettiM. (2008) Chemotaxonomy of Linaria genus by nor-iridoids distribution. Natural Product Communications, 3, 847–848.
16.
TundisR, DeguinB, DodaroD, StattiGA, TillequinF, MenichiniF. (2008) Iridoid glycosides from Linaria multicaulis (L.) Miller subsp. multicaulis (Scrophulariaceae). Biochemical Systematics and Ecology, 36, 142–145.
17.
ZhangT, ZhouJ, WangQ. (2007) Flavonoids from aerial part of Bupleurum chinense DC. Biochemical Systematics and Ecology, 35, 801–804.
18.
BnouhamM, ZiyyatA, MekhfiH, TahriA, LegssyerA. (2006) Medicinal plants with potential antidiabetic activity- A review of ten years of herbal medicine research (1990-2000). International Journal of Diabetes and Metabolism, 14, 1–225.
19.
JeraldE, JoshiSB, JainDC. (2008) Diabetes and herbal medicines. Iranian Journal of Pharmacology and Therapeutics, 7, 97–106.
LeeSH, LiY, KaradenizF, KimMM, KimSK. (2009) α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava. Journal of the Science of Food and Agriculture, 89, 1552–1558.
