Gentiana, a cosmopolitan and important genus of the Gentianaceae family, comprises over 300 species distributed among the world. Phytochemical investigations on the title genus have led to characterization of almost two hundred secondary metabolites. Some of them have shown promising bioactivities. Herein, we have summarized the phytochemical and pharmacological progress of this genus. This review covers the period 1960-June, 2009.
CheYY, LiangJY. (2008) Progress of the research on Gentiana species. Strait Pharmaceutical Journal, 20, 1–4.
2.
WuQX, LiuX, ShiYP. (2007) Chemical Components from Gentiana aristata. Chemistry & Biodiversity, 4, 175–182.
3.
WangN, ZhouL. (2001) Progress of the research on the chemical constituents from Gentiana species. Shaanxi Forest Science and Technology, No. 3, 71–78.
4.
CaoFH, LiC. (2008) New Advances in Research of Chemical Constituents and Pharmacological Activities of Genus Getiana. Chinese Journal of New Drugs, 17, 27–32.
5.
MuZQ, YuY, GaoH, JiaoWH, YaoXS. (2009) Chemical and Pharmacological Research for Sect Aptera (Getiana). China Journal of Chinese Materia Medica, 34, 2012–2017.
6.
AberhamA, SchwaigerS, StuppnerH, GanzeraM. (2007) Quantitative analysis of iridoids, secoiridoids, xanthones and xanthone glycosides in Gentiana lutea L. roots by RP-HPLC and LC-MS. Journal of Pharmaceutical and Biomedical Analysis, 45, 437–442.
7.
BiancoA, RamunnoA, MelchioniC. (2003) Iridoids from seeds of Gentiana lutea. Natural Product Research, 17, 221–224.
CalisI, ErsözT, ChuliaAJ, RüediP. (1992) Septemfidoside: a new bis-iridoid diglucoside from Gentiana septemfida. Journal of Natural Products, 55, 385–388.
10.
XuM, ZhangM, ZhangYJ, YangCR. (2009) New Acylated Secoiridoid Glucosides from Gentiana straminea. Helvetica Chimica Acta, 92, 321–327.
11.
MpondoME, GarciaJ. (1989) Iridoids from Gentiana verna. Phytochemistry, 28, 2503–2504.
12.
TanRX, HuJ, KongLD, WolfenderJL, HostettmannK. (1997) Two new secoiridoid glycosides from Gentiana algida. Planta Medica, 63, 567–568.
13.
GarciaJ, MpondoME. (1989) Loganin and a new iridoid glucoside from Gentiana pyrenaica. Journal of Natural Products, 52, 423–425.
14.
GarciaJ, ChuliaAJ. (1986) Loganin and new iridoid glucosides from Gentiana pedicellata. Planta Medica, 52, 327–328.
15.
BergeronC, MarstonA, GauthierR, HostettmannK. (1997) Iridoids and secoiridoids from Gentiana linearis. Phytochemistry, 44, 633–637.
16.
ChuliaAJ, VercauterenJ, MariotteAM, (1996) Iridoids and secoiridoids from Gentiana depressa. Phytochemistry, 42, 139–143
17.
MpondoME, GarciaJ. (1990) Two iridoid glucosides from Gentiana verna. Phytochemistry, 29, 643–644.
18.
KumarV, ChandR, AuziA, IkeshiroY, SarkerSD. (2003) 2’-(2,3-Dihydroxybenzoyloxy)-7-ketologanin: A novel iridoid glucoside from the leaves of Gentiana kurroo. Pharmazie, 58, 668–670.
ChenQL, SunWJ, TuGZ, ShiZY, ZhangYM. (2006) Chemical constituents of Gentiana macrophylla Pall. from Shaanxi. Natural Product Communications, 1, 527–530.
21.
TanRX, WolfenderJL, MaWG, ZhangLX, HostettmannK. (1996) Secoiridoids and antifungal aromatic acids from Gentiana algida. Phytochemistry, 41, 111–116.
22.
TanRX, WolfenderJL, ZhangLX, MaWG, FuzzatiN, MarstonA, HostettmannK. (1996) Acyl secoiridoids and antifungal constituents from Gentiana macrophylla. Phytochemistry, 42, 1305–1313.
23.
IkeshiroY, MaseI, TomitaY. (1990) A secoiridoid glucoside from Gentiana scabra var.buergeri. Planta Medica, 56, 101–103.
24.
KikuchiM, KakudaR, KikuchiM, YaoitaY. (2005) Secoiridoid Glycosides from Gentiana scabra. Journal of Natural Products, 68, 751–753.
25.
KakudaR, IijimaT, YaoitaY, MachidaK, KikuchiM. (2001) Secoiridoid Glycosides from Gentiana scabra. Journal of Natural Products, 64, 1574–1575.
26.
MpondoME, GarciaJ, LestaniJ. (1989) New secoiridoid glucosides from Gentiana verna. Journal of Natural Products, 52, 1146–1149.
27.
ÖzütrkN, BaserKHC, AydinS, ÖztürkY, CalisI. (2002) Effects of Gentiana lutea ssp. symphyandra on the central nervous system in mice. Phytotherapy Research, 16, 627–631.
28.
LiuHT, WangKT, ZhaoYK, ZhangHY, ChenXG, HuZD. (2000) Identification and determination of active components in Gentiana rigescens Franch by micellar electrokinetic chromatography. Journal of High Resolution Chromatography, 23, 697–698.
TanRX, KongLD. (1997) Secoiridoids from Gentiana siphonantha. Phytochemistry, 46, 1035–1038.
31.
SuhrIH, ArendsP, JensenB. (1978) Gentiolactone, a secoiridoid dilactone from Gentiana purpurea. Phytochemstry, 17, 135–138.
32.
SchaufelbergerD, HostettmannK. (1987) High-performance liquid chromatographic analysis of secoiridoid flavone glycosides in closely related Gentiana species. Journal of Chromatography A, 389, 450–455.
33.
MpondoME, ChuliaAJ. (1988) 6’-O-β-D-Glucosyl gentiopicroside: a new secoiridoid from Gentiana asclepiadea. Planta Medica, 54, 185.
34.
KrstićD, JankovićT, AljančićI, Savikin-FodulovićK, MenkovićN, MilosavljevicS. (2004) Phytochemical investigation of Gentiana dinarica. Biochemical Systematics and Ecology, 32, 937–941.
35.
MaWG, FuzzatiN, WolfenderJI, YangCR, HostettmannK. (1996) Further acylated secoiridoid glucosides from Gentiana rhodantha. Phytochemistry, 43, 805–810.
36.
ChungMI, LinCN. (1993) A new acylated secoiridoid from Gentiana formosana. Journal of Natural Products, 56, 982–983.
37.
TanRX, KongLD, WeiHX. (1998) Secoiridoid glycosides and antifungal anthranilate derivative from Gentiana tibetica. Phytochemistry, 47, 1223–1226.
WagnerH, VasirianK. (1974) Desoxyamarogentin ein neuer bittersfoff aus Gentiana pannonica, Scop Phytochemistry, 13, 615–617
40.
GarciaJ, LavaitteS, GeyC. (1989) 8-Epikingiside and its vanillate ester isolated from Gentiana pyrenaica. Phytochemistry, 28, 2199–2201.
41.
KimJA, SonNS, SonJK, JahngYD, WookChang HW, JangTS, NaMK, LeeSH. (2009) Two New Secoiridoid Glycosides from the Rhizomes of Gentiana scabra Bunge. Archives of Pharmacal Research, 32, 863–867.
42.
ZhouL, LiXK, MiaoF, YangML, YangXJ, SunW, YangJ. (2009) Further studies on the chemical constituents of Chinese folk medicine Gentiana apiata. Journal of Asian Natural Products Research, 11, 345–351.
43.
GarciaJ, MpondoME, CartierG, GeyC. (1989) Secoiridoids and a phenolic glucoside from Gentiana pyrenaica. Journal of Natural Products, 52, 996–1002.
44.
IsakovicA, JankovicT, HarhajiL, Kostic-RajacicS, NikolicZ, VajsdV, TrajkovicV. (2008) Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure–activity requirements. Bioorganic & Medicinal Chemistry, 16, 5683–5694.
45.
TomicM, TovilovicG, ButorovicB, KrsticD, JankovicT, AljanicI, MenkovicN. (2005) Neuropharmacological evaluation of diethylether extract and xanthones of Gentiana kochiana. Pharmacology, Biochemistry and Behavior, 81, 535–542.
46.
Hostettmann-KalkasM, HostettmannK, SticherO. (1981) Xanthones, flavones and secoiridoids of american Gentiana species. phytochemistry, 20, 443.
47.
NikolaevaGG, SergeevAV, NikolaevSM, GlyzinVI, DargaevaTD, SambuevaZG, TsyrenzhapovAV. (2004) Isolation and immunomodulant activity of gentiabavaroside from Gentiana barbata. Pharmaceutical Chemistry Journal, 38, 25–27.
48.
Hostettmann-KaldasM, Jacot-GuillarmodA. (1978) Xanthones et C-glucoside flavoniques du genre Gentiana. Phytochemistry, 17, 2083–2086.
49.
UrbainA, MarstonA, QueirozWF, NdjokoK, HostettmannK. (2004) Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Medica, 70, 1011–1014.
50.
NikolaevaGG, GlyzinVI, MladentsevaMS, SheichenkoVI, PatudinAV. (1983) Xanthones from Gentiana lutea. Chemistry of Natural Compounds, 19, 106–107.
51.
AtkinsonJE, GuptaP, LewisJR. (1969) Some phenolic constituents of Gentiana lutea. Tetrahedron, 25, 1507–1511.
52.
HayashiT, YamagishiT. (1988) Two xanthones glycosides form Gentiana lutea. Phytochemistry, 27, 3696–3699.
SchaufelbergerD, HostettmannK. (1988) Chemistry and pharmacology of Gentiana lacteal. Planta Medica, 54, 219–221.
56.
LinCN, ChangCH, ArisawaM, ShimizuM, MoritaN. (1982) A xanthone glycoside from tripterosprmum taiwanense and rutin from Gentiana flavor-maculata. Phytochemistry, 21, 948–949.
57.
MassiasM, CarbonnierJ, MolhoD. (1981) Xanthones and C-glucosylflavones from Gentiana corymbifera. Phytochemistry, 20, 1577–1578.
LinCN, KuoSH, ChungMI, KoFN, TengCM (1997) A New Flavone C-Glycoside and Antiplatelet and Vasorelaxing Flavones from Gentiana arisanensis. Journal of Natural Products, 60, 851–853.
60.
LiuB, YueME, YangSR, ShiYP. (2005) Determination of phenolic glucosides in Gentiana piasezkii by capillary zone electrophoresis. Chromatographia, 62, 643–647.
61.
KuoSH, YenMH, ChungMI, LinCN. (1996) A flavone C-glycoside and an aromatic glucoside from Gentiana species. Phytochemistry, 41, 309–312.
XuM, WangD, ZhangYJ, YangCR. (2007) Dammarane Triterpenoids from the Roots of Gentiana rigescens. Journal of Natural Products, 70, 880–883.
68.
ToriumiY, KakudaR, KikuchiM, YaoitaY, KikuchiM. (2003) New Triterpenoids fromGentiana lutea Chemical & Pharmaceutical Bulletin, 51, 89–91.
69.
KakudaR, MachidaK, YaoitaY, KikuchiM, KikuchiM. (2003) Studies on the constituents of Gentiana species. II: A new triterpenoid, and (S)-(1)- and (R)-(2)-gentiolactones from Gentiana lutea. Chemical & Pharmaceutical Bulletin, 51, 885–887.
70.
ZhangYJ, YangCR. (1994) Two triterpenoids from Gentiana tibetica. Phytochemistry, 36, 997–999.
71.
AnamEM. (1998) Two triterpenoids form Gentiana neurotheca. Phytochemistry, 48, 211–213.
72.
RakhmatullaevTU, AkramovST, YunusovSY. (1969) Alkaloids of Gentiana olivieri. Chemistry of Natural Compounds, 5, 608–608.
73.
RakhmatullaevTU, YunusovSY. (1973) Alkaloids of Gentiana olivieri. Chemistry of Natural Compounds, 9, 56–58.
74.
RakhmatullaevTU, YunusovSY. (1972) Alkaloids of Gentiana olivieri. Chemistry of Natural Compounds, 8, 344–345.
75.
SamatovA, AkramovST, YunusovSY. (1967) Alkaloids of Gentiana. Structure of gentianadine and gentianamine. Chemistry of Natural Compounds, 3, 150–154.
76.
TianschaniaG, ConnataS. (1971) Alkaloids of Gentiana olgae, G. vvedenski, G.tianschania and Swertia connata. Chemistry of Natural Compounds, 7, 123–123.
77.
MaWG, FuzzatiN, WolfenderJL, HostettmannK, YangCR. (1994) Rhodenthoside A, a new type of acylated secoiridoid glycoside from Gentiana rhodentha. Helvetica Chimica Acta, 77, 1660–1671.
78.
KitanovGM, SpassovSL. (1992) A naphthodipyrano dione from Gentiana asclepiadea. Phytochemistry, 31, 1067–1068.
79.
GarciaJ, MpondoME, ChuliaAJ, KaouadjiM, CartierG. (1989) Two phthalide glucosides from Gentiana pyrenaica. Phytochemistry, 28, 1759–1760.
80.
MpondoME, GarciaJ, ChuliaAJ. (1987) New phthalides from Gentiana pedicellata. Planta Medica, 53, 297–298.
MpondoME, GarciaJ, ChuliaAJ, MariotteAM. (1989) A New C13 glycoside from Gentiana pneumonanthe. Planta Medica, 55, 492–492.
83.
SezikaE, AslanaM, YesiladaaE, ItoS. (2005) Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay- directed fractionation techniques. Life Sciences, 76, 1223–1238.
84.
BaragattiB, CalderoneV, TestaiL, MartinottiE, ChericoniS, MorelliI. (2002) Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. Journal of Ethnopharmacology, 79, 369–372.
85.
AminA. (2008) Ketoconazole-induced testicular damage in rats reduced by Gentiana extract. Experimental and Toxicologic Pathology, 59, 377–384.
86.
YuFR, YuFH, LiRD, WangR. (2004) Inhibitory effects of the Gentiana macrophylla (Gentianaceae) extract on rheumatoid arthritis of rats. Journal of Ethnopharmacology, 95, 77–81.