A new stemphol derivative, stemphol 1-O-β-D-galactopyranoside (1b), together with three known metabolites, stemphol (1a), indole-3-carboxylic acid, and kojic acid, has been isolated from the ethyl acetate extract of cultures of Gaeumannomyces amomi BCC4066, an endophytic fungus found on healthy parts of ginger (Alpinia malaccensis; Thai name Kha-pa). The structure of 1b was established via spectroscopic methods, including 2D NMR measurements and GC/MS experiments.
VlietinckAJ, ApersS. (2001) Biological screening methods in the search for pharmacologically active natural products. In Bioactive compounds from natural sources. TringaliC (Ed), Taylor and Francis Inc, New York, 1–30.
2.
BaconCW, WhiteJF. (2000) Microbial endophytes.Marcel Dekker Inc, New York, 1–487.
3.
StrobelG, DaisyB. (2003) Bioprospecting for microbial endophytes and their natural products. Microbiology and Molecular Biology Reviews, 67, 491–502.
4.
VermaVC, KharwarRN, StrobelGA. (2009) Chemical and functional diversity of natural products from plant associated endophytic fungi. Natural Product Communications, 4, 1511–1532.
5.
StrobelGA, Vincent MillerR, Martinez-MillerC, CondronMM, TeplowDB, HessWM. (1999) Cryptocandin, a potent antimycotic from the endophytic fungus Crptosporiopsis cf. quercina. Microbiology, 145, 1919–1926.
6.
BussabanB, LumyongS, LumyongP, HydeKD, McKenzieEHC. (2001) Two new species of endophytes (ascomycetes) from Zingiberaceae sporulating in culture. Nova Hedwigia, 73, 487–493.
7.
LumyongS, BussabanB, LumyongP, HydeKD, MckenzieEHC, AsanoK, TomitaF. (2004) Evaluation of endophytic fungi from Zingiberaceae for antibiotic production. Biotechnology for Sustainable Utilization of Biological Resources in the Tropics, 17, 472–476; Chemical Abstracts, 144, 83735.
StodolaFH, WeislederD, VesonderRF. (1973) A new dialkylresorcinol from Stemphylium majusculum. Phytochemistry, 12, 1797–1798.
10.
StodolaF, HattoriH, KatayamaM. (1985) Stemphol from Pleospora herbarum as a self-inhibitor. Agricultural and Biological Chemistry, 49, 1521–1522.
11.
AchenbachH, KohlW. (1979) Elucidation of the structure of pigments of the flexirubin-type - mass spectrometry studies. Chemische Berichte, 112, 209–217.
12.
El AasarSA. (2006) Cultural conditions studies on kojic acid production by Aspergillus parasiticus. International Journal of Agriculture and Biology, 8, 468–473.
13.
LaatschH. (2009) AntiBase, A Data Base for Rapid Dereplication and Structure Determination of Microbial Natural Products, Wiley-VCH, Weinheim, Germany; see http://wwwuser.gwdg.de/~ucoc/laatsch/AntiBase.htm.
14.
KlyneW. (1950) The configuration of the anomeric carbon atoms in some cardiac glycosides. The Biochemical Journal, 47, XLI–XLII.
15.
QinJC, ZhangYM, GaoJM, BaiMS, YangSX, LaatschH, ZhangAL. (2009) Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba. Bioorganic and Medicinal Chemistry Letters, 19, 1572–1574.