A new trinortriterpenoid, diospyrolide acetate (1) and a new diphenylmethane derivative, pulcherrimumin (12), together with ten known pentacyclic triterpenoids (2–11) and four aromatic compounds (13–16), were isolated from the liverwort Ptilidium pulcherrimum. Their structures were established on the basis of extensive analysis of NMR data and by chemical methods. The cytotoxicity of compounds 1–16 was evaluated against the PC3, MDA-MB-231, and Hela cells lines. Ursane triterpenoids 8–10 exhibited moderate cytotoxicity against PC3 cells with IC50 values ranging from 10.1 to 39.7 μM.
LiZJ, LouHX, YuWT, FanPH, RenDM, MaB, JiM. (2005) Structures and absolute configurations of three 7,8-secolabdane diterpenes from the Chinese liverwort Pallavicinia ambigua. Helvetica Chimica Acta, 88, 2637–2640;
2.
NiuC, QuJB, LouHX. (2006) Antifungal bis[bibenzyls] from the Chinese liverwort Marchantia polymorpha L. Chemistry & Biodiversity, 3, 34–40;
3.
LuZQ, FanPH, JiM, LouHX. (2006) Terpenoids and bisbibenzyls from Chinese liverworts Conocephalum conicum and Dumortiera hirsuta. Journal of Asian Natural Products Research, 8, 187–192;
4.
MaB, LuZQ, GuoHF, LouHX. (2007) Rearranged calamenene and eudesmane sesquiterpenoids from two Chinese liverworts. Helvetica Chimica Acta, 90, 52–57;
5.
MaB, GuoHF, LouHX. (2007) A new lignan and two eudesmanes from Lepidozia vitrea. Helvetica Chimica Acta, 90, 58–62;
6.
XieCF, QuJB, SunB, GuoHF, LouHX. (2007) Dumhirone A, an unusual phenylethyl cyclohexadienone from the Chinese liverwort Dumortiera hirsuta. Biochemical Systematics and Ecology, 35, 162–165;
7.
QuJB, XieCF, GuoHF, YuWT, LouHX. (2007) Antifungal dibenzofuran bis(bibenzyl)s from the liverwort Asterella angusta. Phytochemistry, 68, 1767–1774;
8.
QuJB, XieCF, JiM, ShiYQ, LouHX. (2007) Water-soluble constituents from the liverwort Marchantia polymorpha. Helvetica Chimica Acta, 90, 2109–2115;
9.
QuJB, ZhuRL, ZhangYL, GuoHF, WangXN, XieCF, YuWT, JiM, LouHX. (2008) ent-Kaurane diterpenoids from the liverwort Jungermannia atrobrunnea. Journal of Natural Products, 71, 1418–1422.
KuoYH, ChangCI. (2000) Six new compounds from the heartwood of Diospyros maritima. Chemical and Pharmaceutical Bulletin, 48, 1211–1214;
12.
LeeSS, ChangSM, ChenCH. (2001) Chemical constituents from Alseodaphne andersonii. Journal of Natural Products, 64, 1548–1551;
13.
KamperdickC, AdamG, VanNH, Van SungT. (1997) Chemical constituents of Madhuca pasquiery. Zeitschrift für Naturforschung. C, Journal of Biosciences, 52, 295–300;
14.
MahatoSB, KunduAP. (1994) 13C NMR spectra of pentacyclic triterpenoids-a compilation and some salient features. Phytochemistry, 37, 1517–1575;
15.
HuneckS, TønsbergT, BohlmannF. (1986) (–)-Allo-pertusaric acid and (–)-dihydropertusaric acid from the lichen Pertusaria albescens. Phytochemistry, 25, 453–459;
16.
ChiangYM, ChangJY, KuoCC, ChangCY, KuoYH. (2005) Cytotoxic triterpenes from the aerial roots of Ficus microcarpa. Phytochemistry, 66, 495–501;
17.
FangJM, WangKC, ChengYS. (1991) Steroids and triterpenoids from Rosa laevigata. Phytochemistry, 30, 3383–3387;
18.
YangMH, BlundenG, O'NeillMJ, LewisJA. (1992) Tormentic acid and 2α-hydroxyursolic acid from Arnebia euchroma. Planta Medica, 58, 227–231;
19.
TkachevAV, DenisovAY. (1994) Oxidative decarboxylation by hydrogen peroxide and a mercury (II) salt: a simple route to norderivatives of acetyloleanolic, acetylursolic and dehydroabietic acids. Tetrahedron, 50, 2591–2598;
20.
YangH, JiangB, HouAJ, LinZW, SunHD. (2000) Colebroside A, a new diglucoside of fatty acid ester of glycerin from Clerodendrum colebrookianum. Journal of Asian Natural Products Research, 2, 177–185;
21.
AsakawaY, ToyotaM, von KonratM, BragginsJE. (2003) Volatile components of selected species of the liverwort genera Frullania and Schusterella (Frullaniaceae) from New Zealand, Australia and South America: a chemosystematic approach. Phytochemistry, 62, 439–452;