From the ethanolic extract of Caesalpinia bonduc, one new diterpene, neocaesalpin P (1) and six known diterpenoids, neocaesalpin H (2), cordylane A (3), caesalpinin B (4), bonducellpin E (5), caesalpinolide A (6), and 17-methylvouacapane-8(14),-9(11)-diene (7) were isolated. Structures of these compounds were determined from NMR spectroscopic studies. Compounds 1-7 exhibited modest antibacterial activities. All of these compounds were weakly active in glutathione S-transferase inhibition assays.
YadavPP, AroraA, BidHK, KonwarRR, KanojiyaS. (2007) New cassane butenolide hemiketal diterpenes from the marine creeper Caesalpinia bonduc and their antiproliferative activity. Tetrahedron Letters, 48, 7194–7198.
2.
ChakrabartiS, BiswasTK, RokeyaB, AliL, MosihuzzamanM, NaharN, KhanAKA, MukherjeeB. (2003) Advanced studies on the hypoglycemic effect of Caesalpinia bonducella F. in type 1 and 2 diabetes in Long Evans rats. Journal of Ethnopharmacology, 84, 41–46.
3.
SiminK, Kaliq-uz-ZamanSM, AhmadVU. (2001) Antimicrobial activity of seed extracts and bondenolide from Caesalpinia bonduc (L.) Roxb. Phytotherapy Research, 15, 437–440.
4.
KannurDM, HukkeriVI, AkkiKS. (2006) Adaptogenic activity of Caesalpinia bonduc seed extracts in rats. Journal of Ethnopharmacology, 108, 327–331.
5.
AliME, Qudrat-i-KhudaM. (1960) Bitter constituents from Caesalpinia bonduc Flem. Chemistry and Industry, 463–464.
6.
PascoeKO, BurkeBA, ChanWR. (1986) Caesalpin F: a new furanoditerpene from Caesalpinia bonducella. Journal of Natural Products, 49, 913–915.
7.
PeterSR, TintoWF, McLeanS, ReynoldsWF, TayLL, YuM, ChanWR. (1998) Complete 1H and 13C NMR assignments of four caesalpin furanoditerpenes of Caesalpinia bonducella. Magnetic Resonance in Chemistry, 36, 124–127.
8.
PeterSR, TintoWF, McLeanS, ReynoldsWF, YuM. (1997) Bonducellpins A–D, new cassane furanoditerpenes of Caesalpinia bonduc. Journal of Natural Products, 60, 1219–1221.
9.
AhmadVU, AliMS, UsmanghaniK. (1997) Bondenolide, a new diterpenoid from the seeds of Caesalpinia bonduc. Zeitschrift für Naturforschung, 53B, 401–412.
10.
PaviaDL, LampmanGM, KrizGS. (2001) Introduction to spectroscopy, 3rd Ed, Brooks/Cole Thomson Learning, USA.
11.
RoachJS, McLeanS, ReynoldsWF, TintoWF. (2003) Cassane diterpenoids of Caesalpinia pulcherrima. Journal of Natural Products, 66, 1378–1381.
12.
KinoshitaT, HagaY, NamrimatsuS.ShimadaM, GodaY. (2005) The isolation and structure elucidation of new cassane diterpene-acids from Caesalpinia crista L. (Fabaceae), and review on the nomenclature of some Caesalpinia species. Chemical and Pharmaceutical Bulletin, 53, 717–720.
13.
HouY, CaoS, BrodieP, MillerJS, BirkinshawC, RatovosonF, RakotondrajaonaR, AndriantsiferanaR, RasamisonVE, KingstonDGI. (2008) Antiproliferative cassane diterpenoids of Cordyla madagascariensis ssp. madagascariensis from the Madagascar rainforest. Journal of Natural Products, 71, 150–152.
14.
LyderDL, TintoWF, BissadaSM, McLeanS, ReynoldsWF. (1998) Caesalpinin B, a rearranged cassane furanoditerpene of Caesalpinia bonduc. Heterocycles, 48, 1465–1469.
15.
PudhomK, SommitD, SuwankittiN, PetsomA. (2007) Cassane furanoditerpenoids from the seed kernels of Caesalpinia bonduc from Thailand. Journal of Natural Products, 70, 1542–1544.
16.
JadhavAN, KaurN, BhutaniKK. (2003) A new furanoditerpenoid marker for the distinction between the seeds of two species of Caesalpinia. Phytochemical Analysis, 14, 315–318.
17.
AtaA, AckermanJ, BayoudA, RadhikaA. (2004) Bioactive chemical constituents of Cladiella species. Helvetica Chimica Acta, 87, 592–597.
18.
AtaA, WinHY, HoltD, HollowayP, SegstroEP, JayatilakeGS. (2004) New antibacterial diterpenoids from Pseudopterogorgia elisabethae. Helvetica Chimica Acta, 87, 1090–1098.
19.
AtaA, UdenigweCC. (2008) The discovery and application of inhibitors of glutathione S-transferase as therapeutic agents -a review. Current Bioactive Compounds, 4, 41–50.
20.
AtaA, AndreshBJ. (2008) Buxus steroidal alkaloids: chemistry and biology. In CordellGA. (Ed.), The Alkaloids, Vol. 66, Elsevier Science Publishers, Amsterdam, pp. 191–213.
