Two new isoflavonoids have been isolated from the aerial parts of Colutea istria Lam. of Egyptian origin and identified as (3R)-7-hydroxy-3′,4′-dimethoxyisoflavan-2′,5′-quinone (1) and 6,3′-dihydroxy-7,4′-dimethoxyisoflavone (2). Their structures were determined by various 1D and 2D NMR spectroscopic techniques. The antibacterial, antifungal, antimalarial and cytotoxic activities of 1 and 2 were evaluated. Compound 1 displayed selective antimicrobial activity against Methicillin-resistant Staphylococcus aureus with an IC50 value of 20 μg/mL.
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