Rubus species (Rosaceae) are appreciated for their fruits and their traditional therapeutic uses. Several experimental investigations indicate important biological effects of these plants, related to the presence of different classes of chemical substances, especially terpenoids and phenolic compounds. This work outlines the main biological properties and chemical constituents of the genus Rubus over the last 10 years, with particular emphasis on the plants that occur in Brazil.
MacielMAM, PintoAC, VeigaJRF. (2002) Plantas Medicinais: A necessidade de estudos multidisciplinares. Química Nova, 25, 429–238.
2.
ElisabetskiE, SouzaGC. (2004) Etnofarmacologia como ferramenta na busca de substâncias ativas In: Farmacognosia: Da planta ao medicamento. Vol. 5, SimõesMOS (Ed). Editora da UFRGS, Porto Alegre, Brazil, 107–122.
3.
Cechinel-FilhoV, YunesRA. (1998) Estratégias para a obtenção de compostos farmacologicamente ativos a partir de plantas medicinais. Química Nova, 21, 99–105.
4.
Cechinel-FilhoV. (2000) Principais avanços e perspectivas na área de produtos naturais ativos: Estudos desenvolvidos no NIQFAR/UNIVALI, 23, 680–685.
5.
BendazzoliWS. (2000) Fitomedicamentos. Perspectivas de resgate de uma terapia histórica. Mundo Saúde, 24, 123–126.
6.
NieroR, MalheirosA, BittencourtCMS, BiavattiMW, LeiteSN, Cechinel-FilhoV. (2003) Aspectos químicos e biológicos de plantas medicinais e considerações sobre fitoterápicos. In: Ciências Farmacêuticas. Contribuição ao Desenvolvimento de Novos Fármacos e Medicamentos. Vol. 1, Cechinel-FilhoV, BresolinTMB (Ed). Editora da Univali, Itajaí, Brazil, 10–56.
7.
Da SilvaKL, Cechinel-FilhoV. (2002) Plantas do gênero Bauhinia: Composição química e potencial farmacológico. Química Nova, 25, 449–454.
8.
BalunasMJ, KinghornAD. (2005) Drug discovery from medicinal plants. Life Sciences, 78, 431–441.
9.
NewmanDJ, CraggGM, SnaderKM. (2003) Natural products as sources of new drugs over the period 1981–2002. Journal of Natural Products, 66, 1022–1037.
10.
LesneyMS. (2004) Nature's pharmaceutical: Natural products from plants remain at the core of modern medicinal chemistry. Today Chemistry at Work, 22–32.
11.
NewmanDJ, CraggGM, (2007) Natural products as sources of new drugs over the last 25 years. Journal of Natural Products, 70, 461–477.
12.
YunesRA, PedrosaRC, Cechinel-FilhoV. (2001) Fármacos e fitoterápicos: a necessidade do desenvolvimento da indústria de fitoterápicos e fitofármacos no Brasil. Química. Nova, 24, 147–152.
13.
GorgeLIFE, MarkmanBED. (1993) Caracterização histológica das folhas e dos frutos de Rubus rosaefolius Smith (amora do mato). Revista do Instituto Adolfo Lutz, 53, 1–4.
14.
PatelAV, Rojas-VeraJ, DackeCG. (2004) Therapeutic constituents and actions of Rubus species. Current Medicinal Chemistry, 11, 1501–1512.
15.
JolyAB. (1991) Introdução à taxonomia vegetal In: Botânica. 10a ed. Companhia Editora Nacional, São Paulo, Brazil.
ChoiJ, LeeKT, YunSY, JungHJ, ParkHJ. (2003) Antinociceptive and anti-inflammatory effects of niga-ichigoside F1 and 23-hydroxytormentic acid obtained from Rubus coreanus. Biological & Pharmaceutical Bulletin, 26, 1436–1441.
19.
JungSW, ShinMH, JungJH, KimND, ImKS. (2001) A triterpene glucosyl ester from the roots of Rubus crataegifolius. Archives of Pharmacal Research, 24, 412–415.
20.
HusseinSA, AyoubNA, NawwarMA. (2003) Caffeoyl sugar esters and an ellagitanin from Rubus sanctus. Phytochemistry, 63, 905–911.
21.
Maatta-RiihinenKR, Kamal-EldinA, TorronenAR. (2004) Identification and quantification of phenolic compounds in berries of Fragaria and Rubus species (family Rosaceae). Journal of Agriculture and Food Chemistry, 6, 6178–6187.
22.
RichardsRM, DurhamDG, LiuX. (1994) Antibacterial activity of compounds from Rubus pinfaensis. Planta Medica, 60, 471–473.
23.
GudejJ. (2003) Kaempferol and quercetin glycosides from Rubus idaeus L. leavesActa Poloniae Pharmaceutica, 60, 313–315.
24.
MullenW, McGinnJ, LeanME, MacLeanMR, GardnerP, DuthieGG, YokotaT, CrozierA. (2002) Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. Journal of Agriculture and Food Chemistry, 50, 5191–5196.
25.
Rojas-VeraJ, PatelAV, DackeCG. (2002) Relaxant activity of raspberry (Rubus idaeus) leaf extract in guinea-pig ileum in vitro. Phytotherapy Research, 16, 665–668.
26.
KhandujaKL. (1999) Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin mice. Food and Chemical Toxicology, 37, 313–318.
27.
KreanderK, GalkinA, VuorelaS, TammelaP, LaitinenL, HeinonenM, VuorelaP. (2006) In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions. Journal of Pharmacy and Pharmacology, 58, 1545–1552.
28.
SkupienK, OszmianskiJ, Kostrzewa-NowakD, TarasiukJ. (2006) In vitro antileukaemic activity of extracts from berry plant leaves against sensitive and multidrug resistant HL60 cells. Cancer Letter, 236, 282–291.
29.
VenskutonisPR, DvaranauskaitemA, LabokasJ. (2007) Radical scavenging activity and composition of raspberry (Rubus idaeus) leaves from different locations in Lithuania. Fitoterapia, 78, 162–165.
30.
LemusI. (1999) Hypoglycemic activity of four plants used in Chilean popular medicine. Phytotherapy Research, 13, 91–94.
31.
JouadH, MaghraniM, EddouksM. (2002) Hypoglycaemic effect of Rubus fructicosis L. and Globularia alypum L. in normal and streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 81, 351–356.
32.
PanizziL, CaponiC, CatalanoS, CioniPL, MorelliI. (2002) In vitro antimicrobial activity of extracts and isolated constituents of Rubus ulmifolius. Journal of Ethnopharmacology, 79, 165–168.
33.
FlaminiG, CatalanoS, CaponiC, PanizziL, MorelliI. (2002) Three anthrones from Rubus ulmifolius. Phytochemistry, 59, 873–876.
34.
RauhaJP. (2000) Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. International Journal of Food and Microbiolgy, 70, 275–280.
PaivarintaE, PajariAM, TorronenR, MutanenM. (2006) Ellagic acid and natural sources of ellagitannins as possible chemopreventive agents against intestinal tumorigenesis in the Min mouse. Nutrition and Cancer, 54, 79–83.
37.
KimTG. (2001) Antiviral activities of extracts isolated from Terminalis chebula Retz., Sanguisorba officinalis L., Rubus coreanus Miq and Rheum palmatum L. against hepatitis B virus. Phytotherapy Research, 15, 718–720.
38.
KimEJ, LeeYJ, ShinHK, ParkJH. (2005) Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. Journal of Nutrition, 21, 1141–1148.
39.
ShinTY, KimSH, LeeES, EomDO, KimHM. (2002) Action of Rubus coreanus extract on systemic and local anaphylaxisPhytotherapy Research, 16, 508–513.
40.
LeeKH, ChoiEM. (2006) Rubus coreanus Miq. extract promotes osteoblast differentiation and inhibits bone-resorbing mediators in MC3T3-E1 cells. American Journal of Chinese Medicine, 34, 643–654.
41.
NamJH, JungHJ, ChoiJ, LeeKT, ParkHJ. (2006) The anti-gastropathic and anti-rheumatic effect of niga-ichigoside F1 and 23-hydroxytormentic acid isolated from the unripe fruits of Rubus coreanus in a rat model. Biological Pharmaceutical Bulletin, 29, 967–970.
42.
AlanisAD, CalzadaF, Cedillo-RiveraR, MeckesM. (2003) Antiprotozoal activity of the constituents of Rubus coriifolius. Phytotherapy Research, 17, 681–682.
43.
NieroR, De SouzaMM, Cechinel-FilhoV, Delle MonacheF, YunesR.A. (1999) Antinociceptive activity of niga-ichigoside F1 from Rubus imperialis. Journal of Natural Products, 62, 1145–1146.
44.
LiuR, DingLS, ChenNY, WangMK. (2001) Chemical constituents from the root of Rubus chroosepalus. Yao Xue Xue Bao, 36, 38–44.
45.
OnoM, TateishiM, MasuokaC, KobayashiH, IgoshiK, KomatsuH, ItoY, OkawaM, NoharaTA. (2003) New triterpene glucosyl ester from the fruit of the blackberry (Rubus allegheniensis). Chemical Pharmaceutical Bulletin, 51, 200–202.
46.
MeckesM, David-RiveraAD, Nava-AguilarV, JimenezA. (2004) Activity of some Mexican medicinal plant extracts on carrageenan-induced rat paw edema. Phytomedicine, 11, 446–451.
47.
BarbosaE, CalzadaF, CamposR. (2006) Antigiardial activity of methanolic extracts from Helianthemum glomeratum Lag. and Rubus coriifolius Focke in suckling mice CD-1. Journal of Ethnopharmacology, 108, 395–397.
48.
BarbosaE, CalzadaF, CamposR. (2007) In vivo antigiardial activity of three flavonoids isolated of some medicinal plants used in Mexican traditional medicine for the treatment of diarrhea. Journal of Ethnopharmacology, 109, 552–554.
49.
MurakamiC, IshijimaK, HirotaM, SakaguchiK, YoshidaH, MizushinaY. (2002) Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases. Biochimica Biophysica Acta, 29, 193–200.
50.
WangXR, DuAQ, WangHP (1994) Chemical constituents of Chinese medicinal plant Rubus parviforlius LZhongguo Zhong Yao Za Zhi, 19, 511–512.
51.
WangBG. (1998) Triterpenes and triterpene glycosyl ester from Rubus pungens Camb. var Oldhamii. Phytochemistry, 49, 185–188.
52.
WangBG. (2000) Rubupungenosides A and B, two novel triterpenoid saponins dimers from the aerial parts of Rubus pungens. Journal of Natural Products, 63, 851–854.
53.
CuiCB, ZhaoQC, CaiB, YaoXS, OsadsaH. (2002) Two new and four known polyphenolics obtained as new cell-cycle inhibitors from Rubus aleaefolius Poir. Journal of Asian Natural Products Research, 4, 243–252.
54.
TanakaT, TachibanaH, NonakaG, NishiokaI, HsuFL, KohdaH, TanakaO, (1993) New dimeric, trimeric and tetrameric ellagitannins, lambertianins A-D, from Rubus lambertianus Seringe. Chemical and Pharmaceutical Bulletin, 41, 1214–1220.
55.
NogueiraE, RosaGJ, VassilieffVS. (1998) Involvement of GABA (A)-benzodiazepine receptor in the anxiolytic effect induced by hexanic fraction of Rubus brasiliensis. Journal of Ethnopharmacology, 61, 119–126.
56.
NogueiraE, RosaGJ, HaraguchiM, VassilieffVS. (1998) Anxiolytic effect of Rubus brasilensis in rats and mice. Journal of Ethnopharmacology, 61, 111–117.
57.
NogueiraE, VassilieffVS. (2000) Hypnotic, anticonvulsant and muscle relaxant effects of Rubus brasiliensis. Involvement of GABA (A)-system. Journal of Ethnopharmacology, 70, 275–280.
58.
NovaesAP, RossiC, PoffoC, BurguerC, NieroR, Cechinel-FilhoV. (2001) Preliminary evaluation of the hypoglycemic effects of some Brazilian medicinal plants. Thérapie, 56, 427–430.
59.
NieroR, KanegusukuM, SouzaMM, YunesRA, Cechinel-FilhoV. (2002) Antinociceptive action of extracts and fractions from Rubus imperialis (Rosaceae). Therapie, 57, 242–245.
60.
EmendorferF, EmendorferF, BellatoF, NoldinVF, NieroR, Cechinel-FilhoV, CardozoAM. (2005) Evaluation of the relaxant action of some Brazilian medicinal plants in isolated guinea-pig ileum and rat duodenum. Journal of Pharmacology and Pharmaceutical Science, 18, 63–68.
61.
KanegusukuM, Cechinel-FilhoV, Delle MonacheF, YunesRA, NieroR. (2002) Hypoglycemic activity and phytochemical analysis of Rubus imperialis (Rosaceae). Zeitschrift für Naturforschung C, 57, 272–276.
62.
ArdenghiJV, KanegusukuM, NieroR, Cechinel-FilhoV, YunesRA, Delle MonacheF, SouzaMM. (2006) Analysis of the mechanism of antinociceptive action of niga-ichigoside F1 obtained from Rubus imperialis (Rosaceae). Journal of Pharmacy and Pharmacology, 50, 1669–1675.
MüllerV, ChávezJH, ReginattoFH, ZucolottoSM, NieroR, NavarroD, YunesRA, SchenkelEP, BarardiCR, ZanettiCR, SimõesCM. (2007) Evaluation of antiviral activity of South American plant extracts against herpes simplex virus type 1 and rabies virus. Phytotherapy Research, 10, 970–974.
65.
KanegusukuM, SborsD, BastosSE, SouzaMM, Cechinel-FilhoV, YunesRA, Delle MonacheF, NieroR. (2007) Phytochemical and analgesic activity of extract, fractions and a 19-hydroxyursane-type triterpenoid obtained from Rubus rosaefolius (Rosaceae). Biological & Pharmaceutical Bulletin, 5, 999–1002.
YauMH, CheCT, LiangSM, KongYC, FongWP. (2002) An aqueous extract of Rubus chingii fruits protects primary rat hepatocytes against tert-butyl hydroperoxide induced oxidative stress. Life Science, 72, 329–338.
68.
GuoQL, YangJS. (2005) Studies on chemical constituents in fruit of Rubus chingi. Zhongguo Zhong Yao Za Zhi, 30, 198–200.
69.
LeeJH, HamYA, ChoiSH, ImEO, JungJH, ImKS, KimDK, XuY, WangMW, KimND. (2000) Activity of crude extract of Rubus crataegifolius roots as a potent apoptosis inducer and DNA topoisomerase I inhibitorArchives of Pharmacy Research, 23, 338–343.
LiuZ, SchwimerJ, LiuD, GreenwayFL, AnthonyCT, WolteringEA. (2005) Black raspberry extract and fractions contain angiogenesis inhibitors. Journal of Agriculture and Food Chemistry, 53, 3909–3915.
72.
ErdemogluN, KupeliE, YesiladaE. (2003) Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine. Journal of Ethnopharmocology, 89, 123–129.
73.
LiuZ, SchwimerJ, LiuD, GreenwayFL, AnthonyCT, WolteringEA. (2006) Gallic acid is partially responsible for the antiangiogenic activities of Rubus leaf extract. Phytotherapy Research, 20, 806–813.
74.
ParkJH, OhSM, LimSS, LeeYS, ShinHK, OhYS, ChoeNH, ParkJH, KimJK. (2006) Induction of heme oxygenase-1 mediates the anti-inflammatory effects of the ethanol extract of Rubus coreanus in murine macrophages. Biochemistry and Biophysical Research Communication, 351, 146–152.
75.
WuX, PittmanHE, PriorRL. (2006) Fate of anthocyanins and antioxidant capacity in contents of the gastrointestinal tract of weanling pigs following black raspberry consumption. Journal of Agriculture and Food Chemistry, 54, 583–589.
76.
PatelAV, DackeCG, BlundenG, Rojas-VeraJ. (2007) A straight chain alcohol glycoside, with smooth muscle relaxant activity, from Rubus idaeus (raspberry) leaves. Natural Product Communications, 2, 913–916.