Species of Hypericum accumulate phenolic compounds with the phloroglucinol substitution pattern, and there are many reports of such substances isolated from the aerial parts of the plants. In this study, flowers of plants grown in south Brazil were analyzed by means of HPLC, verifying the presence of benzopyrans in H. polyanthemum and dimeric phloroglucinol derivatives in H. caprifoliatum, H. connatum, H. myrianthum and H. polyanthemum. All flowers presented flavonoids, mainly quercetin derivatives, whereas hypericin and analogues were not detected.
von PoserGL, RechSB, RatesSMK. (2006) Chemical and Pharmacological Aspects of Southern Brazilian Hypericum Species. Teixeira da SilvaJA (ed.) Floriculture and Ornamental Plant Biotechnology. Advances and Tropical Issues.Global Science Books, London, 510–516.
2.
FerrazABF, SchripsemaJ, PohlmannAR, von PoserGL. (2002) Uliginosin B from Hypericum myrianthum Cham. & Schltdl. Biochemical Systematics and Ecology, 30, 989–991.
3.
NörC, AlbringD, FerrazABF, SchripsemaJ, PiresV, SonnetP, GuillaumeD, von PoserGL. (2004) Phloroglucinol derivatives from four Hypericum species belonging to the Trigynobrathys section. Biochemical Systematics and Ecology, 32, 517–519.
4.
RochaL, MarstonA, KaplanMAC, Stoeckli-EvansH, ThullU, TestaB, HostettmannK. (1994) An antifungal gamma-pyrone and xanthones with monoamine oxidase inhibitory activity from Hypericum brasiliense. Phytochemistry, 36, 1381–1385.
5.
RochaL, MarstonA, PotteratO, KaplanMAC, HostettmannK. (1996) More phloroglucinols from Hypericum brasiliense. Phytochemistry, 42, 185–188.
6.
BernardiAP, FerrazAB, AlbringDV, BordignonSAL, SchripsemaJ, Dutra-FilhoCS, HenriquesA, von PoserGL. (2005) Benzophenones from Hypericum carinatum. Journal of Natural Products, 68, 784–786.
7.
FerrazA, BordignonS, StaatsC, von PoserG, SchripsemaJ. (2001) Benzopyrans from Hypericum polyanthemum. Phytochemistry, 57, 1227–1230.
8.
Dall'AgnolR, FerrazA, BernardiAPM, AlbringDV, NörC, SarmentoL, LambL, HassM, von PoserG, SchapovalEES. (2003) Antimicrobial activity of some Hypericum species. Phytomedicine, 10, 511–516.
9.
FerrazABF, LimbergerRP, BordignonSAL, von PoserGL, HenriquesAT. (2005) Essential oil composition of six Hypericum species from southern Brazil. Flavour and Fragrance Journal, 20, 335–339.
10.
GronquistM, BezzeridesA, AttygalleA, MeinwaldJ, EisnerM, EisnerT. (2001) Attractive and defensive functions of the ultraviolet pigments of a flower (Hypericum calycinum). Proceedings of the National Academy of Sciences USA, 98, 13745–13750.
11.
JamesDG, PriceTS, WrightLC. (2003) Mites and aphids in Washington hops: candidates for augmentative or conservation biological control. 1st International Symposium on Biological Control of Arthropods, 189–194.
12.
Dall'AgnolR, FerrazA, BernardiAP, AlbringD, NörC, SchapovalEES, von PoserGL. (2005) Bioassay-guided isolation of antimicrobial benzopyrans and phloroglucinol derivatives from Hypericum species. Phytotherapy Research, 19, 291–293.
13.
BernardiAPM, MaurmannN, RechSB, von PoserGL. (2007) Benzopyrans in Hypericum polyanthemum Klotzsch ex Reichardt cultured in vitro. Acta Physiologiae Plantarum, 29, 165–170.
14.
SouthwellIA, BourkeCA. (2001) Seasonal variation in hypericin content of Hypericum perforatum L. (St. John's wort). Phytochemistry, 56, 437–441;
15.
CouceiroMA, AfreenF, ZobayedSMA, KonzaiT. (2006) Variation in concentrations of major bioactive compounds of St. John's wort: Effects of harvesting time, temperature and germplasm. Plant Sciences, 170, 128–134;
16.
ÇirakC, SağlamB, AyanAK, KevseroğluK. (2006) Morphogenetic and diurnal variation of hypericin in some Hypericum species from Turkey during the course of ontogenesis. Biochemical Systematics and Ecology, 34, 1–13;
17.
ÇirakC, RadušienėJ, JanulisV, IvanauskasL. (2007) Secondary metabolites in Hypericum perfoliatum: variation among plant parts and phenological stages. Botanica Helvetica, 117, 29–36.
18.
AbreuIN, PortoALM, MarsaioliAJ, MazzaferaP. (2004) Distribution of bioactive substances from Hypericum brasiliense during plant growth. Plant Sciences, 167, 949–954.
19.
NahrstedtA, ButterweckV. (1997) Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry, 30, 129–134.
20.
CrockettS, SchanebergB, KhanIA. (2005) Phytochemical profiling of new and old world Hypericum (St. John's Wort) species. Phytochemical Analysis, 16, 479–485.
21.
UrbanekM, BlechtovaL, PospısilovaM, PolasekM. (2002) On-line coupling of capillary isotachophoresis and capillary zone electrophoresis for the determination of flavonoids in methanolic extracts of Hypericum perforatum leaves or flowers. Journal of Chromatography A, 958, 261–271.
22.
FerrazA, BordignonS, MansDRA, SchmittAC, RavazolloAP, von PoserG. (2002) Screening for the presence of hypericins in southern Brazilian species of Hypericum (Guttiferae). Pharmaceutical Biology, 40, 294–297.
23.
KitanovGM. (2001) Hypericun and pseudohypericin in some Hypericum species. Biochemical Systematics and Ecology, 29, 171–178.
24.
RobsonNKB. (1981) Studies in the genus Hypericum L. (Guttiferae) 2. Characters of the genus. Bulletin of the British Museum (Natural History). Botany series, 8, 55–226;
25.
CiccarelliD, AndreucciAC, PagniAM. (2001) Translucent glands and secretory canals in Hypericum perforatum L. (Hypericaceae): morphological, anatomical and histochemical studies during the course of ontogenesis. Annals of Botany, 88, 637–644.
26.
NörC. (2006) Análise química e taxonômica de espécies de Hypericum e avaliação da atividade antiangiogênica. Thesis, MSc. Pharmaceutical Sciences, UFRGS;
27.
BernardiAPM. (2007) Análise química, avaliação da atividade antixidante e obtenção de culturas in vitro de espécies de Hypericum nativas do Rio Grande do Sul. Thesis, PhD, Pharmaceutical Sciences, UFRGS.