Phytochemical investigation of the roots of Astragalus spinosus Forssk (Fabaceae) resulted in the isolation of ten metabolites. The structure of spinocoumarin I (1), a new coumarin derivative, was established as 3-[(cis-2′,5′-dihydroxycinnamoyl)]-7-hydroxy-6-methoxycoumarin. The structures of the isolated compounds were determined using spectroscopic methods. All compounds exhibited weak antiproliferative activity against the A2780 ovarian cancer cell line.
RadwanMM, FarooqA, El-SebakhyNA, AsaadAM, ToaimaSM, KingstonDGI. (2004) Acetals of three new cycloartane-type saponins from Egyptian collections of Astragalus tomentosus.Journal of Natural Products, 67, 487–490.
10.
RadwanMM, El-SebakhyNA, AsaadAM, ToaimaS, KingstonDGI. (2004) Kahiricosides II-V, cycloartane glycosides from an Egyptian collection of Astragalus kahiricus.Phytochemistry, 65, 2909–2913.
11.
VerottaL, GuerriniM, El-SebakhyNA, AsaadAM, ToaimaSM, Abu-SheerME, LuoYD, PezzutoJM. (2001) Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation. Fitoterapia, 72, 894–905.
12.
VerottaL, GuerriniM, El-SebakhyNA, AsaadAM, ToaimaSM, RadwanMM, LuoYD, PezzutoJM. (2002) Cycloartane and oleanane saponins from Egyptian Astragalus spp. as modulators of lymphocyte proliferation. Planta Medica, 68, 986–994.
DarwishFA. (2002) A novel acid analogue of cycloadsurgenin. Alexandrian Journal of Pharmaceutical Sciences, 16, 57–62.
15.
XianGL, BingHX, QunCY. (1986) The chemical investigation of Astragalus sieverianus Pall. Part 3. The structures of thirteen astrasieversianins from Astragalus sieversianus.Phytochemistry, 25, 2389–2393.
16.
KitagawaI, WangHK, TakaglA, FuchidaM, MiuraI, YoshikawaM. (1983) Saponin and sapogenol. XXXIV. Chemical constituents of Astragalus radix, the roots of Astragalus membranaceous.Chemical & Pharmaceutical Bulletin, 31, 689–697.
17.
AgrawalPK. (1989) Carbon-13 NMR of Flavonoids, Elsevier, Amsterdam.