Two new sulfated steroids, 3β, 5α, 6β- trihydroxy-24-methylene-cholesta-7-ene-3-sodium sulfate (1) and 3β, 5α, 6β-trihydroxy-23E-24-methyl-cholesta-7,23-diene-3-sodium sulfate (2) have been isolated from the sponge, Lendenfeldia dendyi. Their structures were determined on the basis of extensive spectroscopic data (IR, HRMS, 1H and 13C NMR, HMQC, HMBC, COSY and ROESY). The two metabolites lacked antimicrobial activity against Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Cryptococcus neoformans, Mycobacterium intracellulare, Aspergillus fumigatus, and methicillin-resistant Staphylococcus aureus (MRSa).
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