Two new xanthones, 7-hydroxydesoxymorellin (1) and isocaledonixanthone D (2), and four known ones, gaudichaudione H, 1,7-dihydroxy-3-methoxy-2-(3-methyl-2-butenyl)xanthone, 1,5-dihydroxy-3-methoxy-2-(3-methyl-2-butenyl)xanthone, and 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone, as well as lupeol were isolated from the leaves of Garcinia urophylla (Guttiferae). Their structures were determined using a combination of 1D (1H NMR, 13C NMR, DEPT) and 2D (COSY, gHSQC, gHMBC) NMR spectroscopic techniques. Among the isolates, 7-hydroxydesoxymorellin (1), gaudichaudione H, 1,5-dihydroxy-3-methoxy-2-(3-methyl-2-butenyl)xanthone, and 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone demonstrated cytotoxic activities against breast (MCF-7), prostate (DU-145), and lung (NCI-H460) human cancer cell lines.
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6.
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9.
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10.
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11.
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12.
MatsumotoK, AkaoY, KobayashiE, ItoT, OhguchiK, TanakaT, IinumaM, NozawaY. (2003) Cytotoxic benzophenone derivatives from Garcinia species display a strong apoptosis-inducing effect against human leukemia cell lines. Biological and Pharmalogical Bulletin, 26, 569–571.
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15.
ItoC, ItoigawaM, MishinaY, TomiyasuH, LitaudonM, CossonJP, MukainakaT, TokudaH, NishinoH, FurukawaH. (2001) Cancer chemopreventive agents. New depsidones from Garcinia plants. Journal of Natural Products, 64, 147–150.
16.
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17.
MerzaJ, MalletS, LitaudonM, DumontetV, SéraphinD, RichommeP. (2006) New cytotoxic guttiferone analogues from Garcinia virgata from New Caledonia. Planta Medica, 72, 87–89.
18.
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19.
RukachaisirikulV, KamkaewM, SukavisitD, PhongpaichitS, SawangchoteP, TaylorWC. (2003) Antibacterial xanthones from the leaves of Garcinia nigrolineata. Journal of Natural Products, 66, 1531–1535.
20.
SuksamrarnS, SuwannapochN, PhakhodeeW, ThanuhiranlertJ, RatananukulP, ChimnoiN, SuksamrarnA. (2003) Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chemical and Pharmaceutical Bulletin, 51, 857–859.
21.
SukpondmaY, RukachaisirikulV, PhongpaichitS. (2005) Antibacterial caged-tetraprenylated xanthones from the fruits of Garcinia hanburyi. Chemical and Pharmaceutical Bulletin, 53, 850–852.
22.
HayA-E, AumondM-C, MalletS, DumontetV, LitaudonM, RondeauD, RichommeP. (2004) Antioxidant xanthones from Garcinia vieillardii. Journal of Natural Products, 67, 707–709.
23.
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24.
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