Nutritional Relevance of Flavonoids in Disease Prevention

Abstract

Flavonoids are not essential nutrients in that their absence from the diet does not produce deficiency conditions in animals and man. However, many have important similarities to pharmacological agents used in the treatment of disease. Their role as dietary components in disease prevention is less clear. Many potentially anti-carcinogenic and anti-atherogenic effects observed in cell cultures will not be of nutritional relevance unless flavonoids gain access to appropriate cellular sites. The bioavailability of flavonoids will depend on numerous factors including molecular structure, the amount consumed, the food matrix, degree of bioconversion in the gut and tissues, the nutrient status of the host and genetic factors. Moreover, extensive and rapid intestinal and hepatic metabolism of flavonoids suggests that the body may treat them as xenobiotic and potentially toxic compounds requiring rapid elimination. Consequently, in addition to potential health benefits, possible adverse effects of flavonoids in the diet also need to be considered when assessing their roles in the prevention of degenerative diseases.