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Abstract

Objective:

The aim of this study was to assess whether a deferred frozen–thawed embryo transfer (Def-ET) offers any benefits compared to a fresh ET strategy in women who have had 2 or more consecutive in vitro fertilization (IVF)/intracytoplasmic injection (ICSI) cycle failures.

Design:

An observational cohort study in a tertiary referral care center including 416 cycles from women with a previous history of 2 or more consecutive IVF/ICSI failures cycles. Both Def-ET and fresh ET strategies were compared using univariate and multivariate logistic regression models. The main outcome measured was the cumulative live birth rate (CLBR).

Results:

A total of 416 cycles were included in the analysis: 197 in the fresh ET group and 219 in the Def-ET group. The CLBR was not significantly different between the fresh and Def-ET groups (58/197 [29.4%] and 57/219 [26.0%], respectively, P = .437). In addition, after the first ET, there was no significant difference in the live birth rate between the fresh ET and Def-ET groups (50/197 [25.4%] vs 44/219 [20.1%], respectively). Multivariate logistic regression analysis indicated that compared to the fresh strategy, the Def-ET strategy was not associated with a higher probability of live birth.

Conclusions:

In cases with 2 or more consecutive prior IVF/ICSI cycle failures, a Def-ET strategy did not result in better ART outcomes than a fresh ET strategy.

Keywords

fresh embryo transfer frozen-thawed embryo transfer IVF/ICSI ART repeated IVF/ICSI cycle failures

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References

Salamonsen

Nie

Hannan

Dimitriadis

. Society for Reproductive Biology Founders’ Lecture 2009. Preparing fertile soil: the importance of endometrial receptivity. Reprod Fertil Dev. 2009;21(7):923–934.

Achache

Revel

. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update. 2006;12(6):731–746.

European IVF-Monitoring Consortium (EIM), European Society of Human Reproduction and Embryology (ESHRE); Kupka

D’Hooghe

Ferraretti

, et al. Assisted reproductive technology in Europe, 2011: results generated from European registers by ESHRE. Hum Reprod Oxf Engl. 2016;31(2):233–248.

Roberts

Stylianou

. The non-independence of treatment outcomes from repeat IVF cycles: estimates and consequences. Hum Reprod Oxf Engl. 2012;27(2):436–443.

Sharma

Allgar

Rajkhowa

. Factors influencing the cumulative conception rate and discontinuation of in vitro fertilization treatment for infertility. Fertil Steril. 2002;78(1):40–46.

Nikas

Develioglu

Toner

Jones

. Endometrial pinopodes indicate a shift in the window of receptivity in IVF cycles. Hum Reprod Oxf Engl. 1999;14(3):787–792.

Ubaldi

Bourgain

Tournaye

Smitz

Van Steirteghem

Devroey

. Endometrial evaluation by aspiration biopsy on the day of oocyte retrieval in the embryo transfer cycles in patients with serum progesterone rise during the follicular phase. Fertil Steril. 1997;67(3):521–526.

Lass

Peat

Avery

Brinsden

. Histological evaluation of endometrium on the day of oocyte retrieval after gonadotrophin-releasing hormone agonist-follicle stimulating hormone ovulation induction for in-vitro fertilization. Hum Reprod Oxf Engl. 1998;13(11):3203–3205.

Bourgain

Devroey

. The endometrium in stimulated cycles for IVF. Hum Reprod Update. 2003;9(6):515–522.

10.

Haouzi

Assou

Mahmoud

, et al. Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients. Hum Reprod Oxf Engl. 2009;24(6):1436–1445.

11.

Horcajadas

Mínguez

Dopazo

, et al. Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications. J Clin Endocrinol Metab. 2008;93(11):4500–4510.

12.

Junovich

Mayer

Azpiroz

, et al. Ovarian stimulation affects the levels of regulatory endometrial NK cells and angiogenic cytokine VEGF. Am J Reprod Immunol N Y N 1989. 2011;65(2):146–153.

13.

Weinerman

Mainigi

. Why we should transfer frozen instead of fresh embryos: the translational rationale. Fertil Steril. 2014;102(1):10–18.

14.

Evans

Hannan

Edgell

, et al. Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence. Hum Reprod Update. 2014;20(6):808–821.

15.

Shapiro

Daneshmand

Garner

Aguirre

Hudson

. Freeze-all can be a superior therapy to another fresh cycle in patients with prior fresh blastocyst implantation failure. Reprod Biomed Online. 2014;29(3):286–290.

16.

Shapiro

Daneshmand

Restrepo

Garner

Aguirre

Hudson

. Matched-cohort comparison of single-embryo transfers in fresh and frozen-thawed embryo transfer cycles. Fertil Steril. 2013;99(2):389–392.

17.

Roque

Lattes

Serra

, et al. Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis. Fertil Steril. 2013;99(1):156–162.

18.

Braddock

Edwards

Hasenberg

Laidley

Levinson

. Informed decision making in outpatient practice: time to get back to basics. JAMA. 1999;282(24):2313–2320.

19.

Bourdon

Santulli

Gayet

, et al. Assisted reproduction technique outcomes for fresh versus deferred cryopreserved day-2 embryo transfer: a retrospective matched cohort study. Reprod Biomed Online. 2016;34(3):248–257.

20.

de Ziegler

Gayet

Aubriot

, et al. Use of oral contraceptives in women with endometriosis before assisted reproduction treatment improves outcomes. Fertil Steril. 2010;94(7):2796–2799.

21.

Santulli

Gayet

Fauque

, et al. HIV-positive patients undertaking ART have longer infertility histories than age-matched control subjects. Fertil Steril. 2011;95(2):507–512.

22.

Fauque

Léandri

Merlet

, et al. Pregnancy outcome and live birth after IVF and ICSI according to embryo quality. J Assist Reprod Genet. 2007;24(5):159–165.

23.

Gardner

Lane

Schoolcraft

. Physiology and culture of the human blastocyst. J Reprod Immunol. 2002;55(1-2):85–100.

24.

Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod Oxf Engl. 2011;26(6):1270–1283.

25.

Zegers-Hochschild

Adamson

de Mouzon

, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril. 2009;92(5):1520–1524.

26.

Maheshwari

McLernon

Bhattacharya

. Cumulative live birth rate: time for a consensus? Hum Reprod Oxf Engl. 2015;30(12):2703–2707.

27.

Germond

Urner

Chanson

Primi

Wirthner

Senn

. What is the most relevant standard of success in assisted reproduction? The cumulated singleton/twin delivery rates per oocyte pick-up: the CUSIDERA and CUTWIDERA. Hum Reprod Oxf Engl. 2004;19(11):2442–2444.

28.

Wong

van Wely

Mol

Repping

Mastenbroek

. Fresh versus frozen embryo transfers in assisted reproduction. Cochrane Database Syst Rev. 2017;3:CD011184.

29.

Glujovsky

Farquhar

Quinteiro Retamar

Alvarez Sedo

Blake

. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2016;(6):CD002118.

30.

Bourdon

Santulli

Gayet

Maignien

Marcellin

Chapron

. Deferred frozen embryo transfer: what benefits can be expected from this strategy in patients with and without endometriosis? J Endometr Pelvic Pain Disord. 2017;9(2):87–97.

31.

Liu

, et al. Altered circular RNA expression in patients with repeated implantation failure. Cell Physiol Biochem. 2017;44(1):303–313.

32.

Gao

Sun

Xie

Fang

Zhao

. Hysteroscopy prior to repeat embryo transfer may improve pregnancy outcomes for asymptomatic women with repeated implantation failure. J Obstet Gynaecol Res. 2015;41(10):1569–1576.

33.

Lédée

Munaut

Aubert

, et al. Specific and extensive endometrial deregulation is present before conception in IVF/ICSI repeated implantation failures (IF) or recurrent miscarriages. J Pathol. 2011;225(4):554–564.

34.

Mao

Zhang

Chen

Kuang

Zhang

. Short-term copper intrauterine device placement improves the implantation and pregnancy rates in women with repeated implantation failure. Fertil Steril. 2017;108(1):55–61.e1.

35.

Siristatidis

Dafopoulos

El-Khayat

, et al. Administration of prednisolone and low molecular weight heparin in patients with repeated implantation failures: a cohort study. Gynecol Endocrinol. 2018;34(2):136–139.

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The Deferred Embryo Transfer Strategy Seems Not to be a Good Option After Repeated IVF/ICSI Cycle Failures

Abstract

Objective:

Design:

Results:

Conclusions:

Keywords

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References

Supplementary Material