Our aim was to determine whether placental A Disintegrin-like Metalloproteinase with ThromboSpondin motif 12 (ADAMTS-12), arylesterase (ARES) levels, total oxidant status (TOS), and total antioxidant status (TAS) differ in preeclampsia, intrahepatic cholestasis of pregnancy (ICP), and uncomplicated pregnancies or not. A prospective case–control study was carried out including 84 pregnant women (26 with ICP, 28 preeclamptic patients, and 30 healthy controls). Levels of ADAMTS-12, TAS, TOS, and ARES were studied in the supernatants of placental tissue homogenates. Placental ADAMTS-12 levels were distributed as 240.9 pg/mg in ICP, 289.7 pg/mg in preeclampsia, and 310.8 pg/mg in control groups. Levels of ADAMTS-12 (odds ratio = 6.509, 95% confidence interval:1.070-39.592, P = .042) in the placenta of the ICP were significantly lower than those in preeclampsia and control groups (P = .004), but no statistical significant difference was determined between preeclampsia and control groups. Decreased levels of placental ADAMTS-12 were found to be associated with ICP, suggesting a possible role of inflammation in the pathogenesis.
RocksNPaulissenGEl HourM. Emerging roles of ADAM and ADAMTS metalloproteinases in cancer. Biochimie. 2008;90(2):369–379.
2.
KumarSRaoNGeR. Emerging roles of ADAMTSs in angiogenesis and cancer. Cancers. 2012;4(4):1252–1299.
3.
PorterSClarkIMKeworkianLEdwardsDR. The ADAMTS metalloproteinases. Biochem J. 2005;386(pt 1):15–27.
4.
ShozuMMinamiNYokoyamaH. ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary. J Mol Endocrinol. 2005;35(2):343–355.
5.
ZhuHLeungPCMacCalmanCD. Expression of ADAMTS-5/implantin in human decidual stromal cells: regulatory effects of cytokines. Hum Rep. 2007;22(1):63–74.
6.
ZhengXL. Structure-function and regulation of ADAMTS-13 protease. J Thromb Haemost. 2013;11(suppl 1):11–23.
7.
MajumdarMKAskewRSchellingS. Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis. Arthritis Rheum. 2007;56(11):3670–364.
8.
LeeSYLeeHSGilM. Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases. Arch Pathol Lab Med. 2014;138(5):643–650.
9.
JungersKALe GoffCSomervilleRPApteSS. Adamts9 is widely expressed during mouse embryo development. Gene Expr Patterns. 2005;5(5):609–617.
10.
ZhuHLeungPCMacCalmanCD. Expression of ADAMTS-5/implantin in human decidual stromal cells: regulatory effects of cytokines. Hum Reprod. 2007;22(1):63–74.
11.
NgYHZhuHPallenCJLeungPCMacCalmanCD. Differential effects of interleukin-1beta and transforming growth factor-beta1 on the expression of the inflammation-associated protein, ADAMTS-1, in human decidual stromal cells in vitro. Hum Reprod. 2006;21(8):1990–1999.
12.
BeristainAGZhuHLeungPC. Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?PLoS One. 2011;6(4):e18473.
13.
ZouJ. The characterization of ADAMTS-12 in the regulation of human trophoblast in vitro. A thesis submitted in partial fulfillment of the requirements for the degree of doctor of philosophy in the faculty of graduate studies. 2010 The University of British Columbia, Vancouver, Canada. (Free Access in PDF form inGoogle.com.tr)
14.
AplinJD. Implantation, trophoblast differentiation and haemochorial placentation: mechanistic evidence in vivo and in vitro. J Cell Sci. 1991;99(Pt 4):681–692.
15.
KnoflerMSimmonsDGLashGEHarrisLKArmantDR. Regulation of trophoblast invasion-a workshop report. Placenta. 2008;29(suppl A):S26–S28.
NorwitzERSchustDJFisherSJ. Implantation and the survival of early pregnancy. N Engl J Med. 2001;345(19):1400–1408.
18.
WallaceAEHostAJWhitleyGSCartwrightJE. Decidual natural killer cell interactions with trophoblasts are impaired in pregnancies at increased risk of preeclampsia. Am J Pathol. 2013;183(6):1853–1861.
19.
DuQPanYZhangY. Placental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation. BMC Med Genomics. 2014;7:42.
20.
Moncada-PazosAObayaAJLlamazaresM. ADAMTS-12 metalloprotease is necessary for normal inflammatory response. J Biol Chem. 2012;287(47):39554–3963.
21.
AksoyANOzturkNAksoyHAkcayF. Paraoxonase and arylesterase activities in patients with preeclampsia. Eurasian J Med. 2008;40(1):10–13.
22.
KumruSAydinSGursuMFOzcanZ. Changes of serum paraoxonase (an HDL-cholesterol-associated lipophilic antioxidant) and arylesterase activities in severe preeclamptic women. Eur J Obstet Gynecol Reprod Biol. 2004;114(2):177–181.
23.
CanMGuvenBBektasSArikanI. Oxidative stress and apoptosis in preeclampsia. Tissue Cell. 2014;46(6):477–481.
24.
OzturkEBalatOAcılmısYGOzcanCPenceSErelO. Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method. J Obstet Gynaecol Res. 2011;37(4):337–342.
25.
PerezMJMaciasRIMarinJJ. Maternal cholestasis induces placental oxidative stress and apoptosis. Protective effect of ursodeoxycholic acid. Placenta. 2006;27(1):34–41.
26.
Report of the American College of Obstetricians and Gynecologists’ and Task Force on Hypertension in Pregnancy. Hypertension in Pregnancy. Obstet Gynecol. 2013;122(5):1122–1131.
27.
LowryOHRosebroughNJFarrALRandallRJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1):265–275.
28.
ErelO. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103–1111.
29.
ErelO. A novel automated direct measurement method for total antioxidant capacity using a new generation more stable ABTS radical cation. Clin Biochem. 2004;37(4):277–285.
30.
WilliamsonCGeenesV. Intrahepatic cholestasis of pregnancy. Obstet Gynecol. 2014;124(1):120–133.
31.
GleicherNBaradDH. Gestational dermatosis shortly after implantation associated with parental class II HLA compatibility and maternal immune activation: preliminary report of a prospective case series. Dermatology. 2011;222(3):206–211.
32.
PaulissenGEl HourMRocksN. Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12. J Immunol. 2012;189(8):4135–4143.
33.
WeiJRichbourghBJiaTLiuC. ADAMTS-12: A multifaced metalloproteinase in arthritis and inflammation. Mediators Inflamm. 2014;2014:649718.
34.
WeiWHuYY. Expression of hypoxia-regulated genes and glycometabolic genes in placenta from patients with intrahepatic cholestasis of pregnancy. Placenta. 2014;35(9):732–736.
35.
ReidRIveyKJRencoretRHStoreyB. Fetal complications of obstetric cholestasis. Br Med J. 1976;1(6014):870–872.
36.
OdegardRAVattenLJNilsenSTSalvesenKAAustgulenR. Preeclampsia and fetal growth. Obstet Gynecol. 2000;96(6):950–955.
37.
ChenMYuanZShanK. Association of Apolipoprotein J gene 866C→T polymorphism with preeclampsia and essential hypertension. Gynecol Obstet Invest. 2005;60(3):133–138.
38.
National High Blood Pressure Education Working Group Report on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 1990;163(5 pt 1):1689–1712.
SaundersRDNakajimaSTRaiSNPanJGercel-TaylorCTaylorDD. Alterations in antibody subclass immune reactivity to trophoblast-derived fetal fibronectin and α2-macroglobulin in women with recurrent pregnancy loss. Am J Reprod Immunol. 2012;68(5):438–449.
41.
StubertJSchattenbergFRichterDUDieterichMBrieseV. Trophoblastic progranulin expression is upregulated in cases of fetal growth restriction and preeclampsia. J Perinat Med. 2012;40(5):475–481.
DesmaraisJACaoMBatemanAMurphyBD. Spatiotemporal expression pattern of progranulin in embryo implantation and placenta formation suggests a role in cell proliferation, remodeling, and angiogenesis. Reproduction. 2008;136(2):247–257.
44.
LuanYKongLHowellD. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthr Cartil. 2008;16(11):1413–1420.
45.
GuoFLaiYTianQLinEKongLLiuC. Granulin-epithelin precursor binds directly to ADAMTS-7 and ADAMTS-12 and inhibits their degradation of cartilage oligomeric matrix protein. Arthritis Rheum. 2010;62(7):2023–2036.
46.
CalSArguellesJMFernandezPLLopez-OtinC. Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats. J Biol Chem. 2001;276(21):17932–17940.
47.
BorbelyAUSandriSFernandesIR. The term basal plate of the human placenta as a source of functional extravillous trophoblast cells. Reprod Biol Endocrinol. 2014;12:7.
48.
BurtonGJSebireNJMyattL. Optimising sample collection for placental research. Placenta. 2014;35(1):9–22.
