Restricted accessResearch articleFirst published online 2015-8
Effects of Resveratrol on Ovarian Morphology,Plasma Anti-Mullerian Hormone,IGF-1 Levels,and Oxidative Stress Parameters in a Rat Model of Polycystic Ovary Syndrome
To evaluate the effects of resveratrol in a rat model of polycystic ovarian syndrome (PCOS).
Study Design:
After PCOS model was formed by subcutaneous dihydrotestosterone pellets, rats were randomly divided into 2 groups. The first group (n = 7) was treated with 1 mL/kg/d isotonic saline and the second group (n = 7) was treated with 10 mg/kg/d resveratrol. Seven rats were taken as controls without any medication.
Results:
Our results showed (1) significant reduction in the number of antral follicle counts (P < .01); (2) significantly decreased plasma anti-Mullerian hormone and insulin-like growth factor 1 levels (P < .01 and P < .05, respectively); (3) significantly lower superoxide dismutase activity (P < .05); and (4) significantly increased glutathione peroxidase content (P < .01) following resveratrol treatment.
Conclusion:
Resveratrol appears to be effective in the treatment of PCOS due to its antioxidant properties. Future clinical studies with different dosages might provide useful implementations to our practice.
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