Reproductive Ability After Uterine Artery Embolization in a Sheep Model: Observation Over 2 Seasons

Abstract

Objective: To investigate the mid-term effect of uterine artery embolization (UAE) on fertility after bilateral UAE with either tris-acryl gelatin microspheres (TAGM) or gelatin particles (GP). Materials and methods: Fertility was compared in 6 ewes that underwent UAE with TAGM, 6 ewes that underwent UAE with GP, and 6 control ewes. All ewes were artificially inseminated or naturally bred for 2 consecutive breeding seasons after UAE. Pregnancies in each breeding season were investigated. Results: Overall, 36 lambs, all normal in appearance, were delivered after 2 breeding seasons. All 18 ewes delivered lambs in at least the first or second breeding season, with 13 having lambs in both the first and second breeding seasons. In the first breeding season after UAE, all 12 ewes in the UAE group delivered lambs, while 5 (83.3%) of the 6 ewes in the control group did. In the second breeding season, 9 (90%) of the 10 ewes that were alive in the UAE group delivered lambs, while 5 (83.3%) of 6 ewes in the control group did. There were no significant differences in the rate of ewes delivering in the first and second breeding season between control and UAE groups (P = .3333; first season, P > .9999; second season, Fisher exact probability test). Conclusion: The mid-term influence of UAE on reproductive ability in sheep was minimal.

Keywords

Animals arteries arterial embolization uterine experimental study interventional procedures.

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References

Ravina JH , Herbreteau D. , Ciraru-Vigneron N. , et al. Arterial embolization to treat uterine myomata. Lancet. 1995; 346(8976):671-672.

Mara M. , Maskova J. , Fucikova Z. , Kuzel D. , Belsan T. , Sosna O. Midterm clinical and first reproductive results of a randomized controlled trial comparing uterine fibroid embolization and myomectomy. Cardiovasc Interv Radiol. 2008;31(1):73-85.

Goldberg J. , Pereira L. , Berghella V. Pregnancy after uterine artery embolization. Obstet Gynecol . 2002;100(5 pt 1):869-872.

Walker WJ , McDowell SJ Pregnancy after uterine artery embolization for leiomyomata: a series of 56 completed pregnancies. Am J Obstet Gynecol. 2006;195(5):1266-1271.

Pabon IP , Magret JP , Unzurrunzaga EA , Garcia IM , Catalan IB , Vieco LC Pregnancy after uterine fibroid embolization: follow-up of 100 patients using tris-acryl gelatin microspheres. Fertil Steril. 2008;90(6):2356-2360.

Spies JB , Ascher SM , Roth AR , Kim J. , Levy EB , Gomez-Jorge J. Uterine artery embolization for leiomyomata: midterm results. Obstet Gynecol. 2001;98(1):29-34.

Pelage JP , Dref OL , Beregi JP , et al. Limited uterine artery embolization with tris-acryl gelatin microspheres for uterine fibroids. J Vasc Interv Radiol. 2003;14(1):15-20.

Katsumori T. , Nakajima K. , Mihara T. , Tokuhiro M. Uterine artery embolization using gelatin sponge particles alone for symptomatic uterine fibroids: midterm results. Am J Roentgenol. 2002;178(1):135-139.

Myers ER

Uterine artery embolization: what more do we need to know?

Obstet Gynecol. 2002;100(5 pt 1):847-848.

10.

Laurent A. , Pelage JP , Wassef M. , Martal J. Fertility after bilateral uterine artery embolization in sheep model. Fertil Steril. 2009;89(5 suppl):1371-1383.

11.

Yamagami T. , Yoshimatsu R. , Matsumoto T. , et al. Fertility after uterine artery embolization: investigation using a sheep model. Reprod Sci. 2010;17(4):350-357.

12.

Osuga K. , Miyayama S. , Yamagami T. , Anai H. , Takahashi M. , Nakamura H. New porous gelatin particles for hepatic arterial embolization-investigation of passage through current microcatheters. Jpn J Cancer Chemother . 2007;34(1): 59-64.

13.

Fukui Y. , Iida K. , Okada A. , Zyouzyou Y. , Wachi S. , Togawa M. Fertility of estrus-induced ewes during the non-breeding season and artificially inseminated with frozen semen imported from New Zealand. J Reprod Dev. 2002;48(5): 485-488.

14.

Kohno H. , Okamoto C. , Iida K. , et al. Comparison of estrus induction and subsequent fertility with two different intravaginal devices in ewes during the non-breeding season . J Reprod Dev. 2005;51(6):805-812.

15.

Fukui Y. , Kohno H. , Togari T. , Hiwasa M. Fertility of ewes inseminated intrauterinally with frozen semen using extender containing bovine serum albumin. J Reprod Dev. 2007;53(4): 959-962.

16.

Mara M. , Fucikova Z. , Kuzel D. , Masakova J. , Dundr P. , Zizka Z. Hysteroscopy after uterine fibroid embolization in women of fertile age. J Obstet Gynecol Res. 2007;33(3): 316-324.

17.

Hehenkamp WJ , Volkers NA , Broekmans FJ , et al. Loss of ovarian reserve after uterine artery embolization: a randomized comparison with hysterectomy. Hum Reprod. 2007; 22(7):1996-2005.

18.

Spies JB , Roth AR , Gonsalves SM , Murphy-Skrzyniarz KM Ovarian function after uterine artery embolization for leiomyomata: assessment with use of serum follicle stimulating hormone assay. J Vasc Interv Radiol. 2001;12(4): 437-442.

19.

Pelage JP , Laurent A. , Bonneau M. , Wassef M. , Rymer R. , Merland JJ Arterial blood supply to the uterus in nonpregnant sheep: a pertinent model for clinical practice? Invest Radiol. 2001 ;36(12):721-725.