Antagonizing Toll-like Receptors to Prevent Preterm Labor

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References

Preterm birth overview. March of Dimes Web site. 2007. www.marchofdimes.com/peristats. Accessed November 30, 2007.

Goldenberg RL , Hauth JC , Andrews WW

Intrauterine infection and preterm delivery

N Engl J Med. 2000;342:1500-1507.

Romero R. , Espinoza J. , Goncalves LF , Kusanovic JP , Friel L. , Hassan S. The role of inflammation and infection in preterm birth. Semin Reprod Med. 2007;25:21-39.

Elovitz MA , Mrinalini C. Animal models of preterm birth. Trends Endocrinol Metab. 2004;15:479-487.

Wang H. , Hirsch E. Bacterially-induced preterm labor and regulation of prostaglandin-metabolizing enzyme expression in mice: the role of Toll-like receptor 4. Biol Reprod. 2003; 69:1957-1963.

Elovitz MA , Wang Z. , Chien EK , Rychlik DF , Phillippe M. A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Am J Pathol. 2003;163:2103-2111.

Pararas MV , Skevaki CL , Kafetzis DA Preterm birth due to maternal infection: causative pathogens and modes of prevention. Eur J Clin Microbiol Infect Dis. 2006;25:562-569.

Gravett MG , Adams KM , Sadowsky DW , et al. Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model. Am J Obstet Gynecol. 2007;197:518.e1-e8.

Fort MM , Mozaffarian A. , Stover AG , et al. A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J Immunol. 2005;174: 6416-6423.