Personalized Medicine for Diabetes

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O'Rahilly S Barroso I Wareham NJ . Genetic factors in type 2 diabetes: the end of the beginning? Science. 2005;307: 370–3.

Reitman ML Schadt EE . Pharmacogenetics of metformin response: a step in the path toward personalized medicine. J Clin Invest. 2007;117: 1226–9.

Sesti G Laratta E Cardellini M Andreozzi F Del Guerra S Irace C Gnasso A Grupillo M Lauro R Hribal ML Perticone F Marchetti P . The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5′-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes. J Clin Endocrinol Metab. 2006;91: 2334–9.

Shu Y Sheardown SA Brown C Owen RP Zhang S Castro RA Ianculescu AG Yue L Lo JC Burchard EG Brett CM Giacomini KM . Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest. 2007;117: 1422–31.

Collins CD Purohit S Podolsky RH Zhao HS Schatz D Eckenrode SE Yang P Hopkins D Muir A Hoffman M McIndoe RA Rewers M She JX . The application of genomic and proteomic technologies in predictive, preventive and personalized medicine. Vascul Pharmacol. 2006;45: 258–67.

Hoffman EP . Skipping toward personalized molecular medicine. N Engl J Med. 2007;357: 2719–22.

Yamagishi S Ueda S Okuda S . Food-derived advanced glycation end products (AGEs): a novel therapeutic target for various disorders. Curr Pharm Des. 2007;13: 2832–6.

Ruaño G Goethe JW Caley C Woolley S Holford TR Kocherla M Windemuth A de Leon J . Physiogenomic comparison of weight profiles of olanzapine- and risperidone-treated patients. Mol Psychiatry. 2007;12: 474–82.

Klein TE Chang JT Cho MK Easton KL Fergerson R Hewett M Lin Z Liu Y Liu S Oliver DE Rubin DL Shafa F Stuart JM Altman RB . Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. Pharmacogenomics J. 2001;1: 167–70.

Bozkurt O de Boer A Grobbee DE Heerdink ER Burger H Klungel OH . Pharmacogenetics of glucose-lowering drug treatment: a systematic review. Mol Diagn Ther. 2007;11: 291–302.

El-Sohemy A . Nutrigenetics. Forum Nutr. 2007;60: 25–30.

Kaput J Dawson K . Complexity of type 2 diabetes mellitus data sets emerging from nutrigenomic research: a case for dimensionality reduction? Mutat Res. 2007;622: 19–32.

In't Veld P Lievens D De Grijse J Ling Z Van der Auwera B Pipeleers-Marichal M Gorus F Pipeleers D . Screening for insulitis in adult autoantibody-positive organ donors. Diabetes. 2007;56: 2400–4.

Mojiminiyi OA Abdella NA . Associations of resistin with inflammation and insulin resistance in patients with type 2 diabetes mellitus. Scand J Clin Lab Invest. 2007;67: 215–25.

Shaibi GQ Cruz ML Weigensberg MJ Toledo-Corral CM Lane CJ Kelly LA Davis JN Koebnick C Ventura EE Roberts CK Goran MI . Adiponectin independently predicts metabolic syndrome in overweight Latino youth. J Clin Endocrinol Metab. 2007;92: 1809–13.

Teixeira RE Malin S . The next generation of artificial pancreas control algorithms. J Diabetes Sci Technol 2008;2: 105–12.

Petrasek D . Systems biology: the case for a systems science approach to diabetes. J Diabetes Sci Technol 2008;2: 131–4.

Eising S Svensson J Skogstrand K Nilsson A Lynch K Andersen PS Lernmark A Hougaard DM Pociot F Norgaard-Pedersen B Nerup J . Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unseected case-control study. Paediatr Perinat Epidemiol. 2007;21: 507–17.

Hattersley AT . Prime suspect: the TCF7L2 gene and type 2 diabetes risk. J Clin Invest. 2007;117: 2077–9.

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Fox CS Heard-Costa N Cupples LA Dupuis J Vasan RS Atwood LD . Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. BMC Med Genet. 2007;8 Suppl 1: S18.

Staevaq-Vieira T Peakman M von Herrath M . Translational minireview series on type 1 diabetes: Immune-based therapeutic approaches for type 1 diabetes. Clin Exp Immunol. 2007;148: 17–31.

Harrison LC . The prospect of vaccination to prevent type 1 diabetes. Hum Vaccin. 2005: 1143–50.

Jermendy G Ruggenenti P . Preventing microalbuminuria in patients with type 2 diabetes. Diabetes Metab Res Rev. 2007;23: 100–10.

Kilpeläinen TO Lakka TA Laaksonen DE Laukkanen O Lindström J Eriksson JG Valle TT Hämäläinen H Aunola S Ilanne-Parikka P Keinänen-Kiukaanniemi S Tuomilehto J Uusitupa M Laakso M ; Finnish Diabetes Prevention Study Group. Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SURI) genes on the risk of developing type 2 diabetes. Physiol Genomics. 2007;31: 264–72.

Chiasson JL . Prevention of Type 2 diabetes: fact or fiction? Expert Opin Pharmacother. 2007;8: 3147–58.

Jurado J Ybarra J Ferrandiz M Comerma L Pou JM . Aminoterminal brain natriuretic peptide is related to the presence of diabetic polyneuropathy independently of cardiovascular disease. Diabetes Care. 2007;30: e86.

Sima AA . Pathological mechanisms involved in diabetic neuropathy: can we slow the process? Curr Opin Investig Drugs. 2006;7: 324–37.

Barrett TG . Differential diagnosis of type 1 diabetes: which genetic syndromes need to be considered? Pediatr Diabetes. 2007;8 Suppl 6: 15–23.

Molven A Ringdal M Nordbø AM Raeder H Støv J Lipkind GM Steiner DF Philipson LH Bergmann I Aarskog D Undlien DE Joner G Søvik O ; the Norwegian Childhood Diabetes Study Group, Bell GI Njølstad PR . Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. Diabetes. 2008 Jan 11.

Fielding AM Brophy S Davies H Williams R . Latent autoimmune diabetes in adults: increased awareness will aid diagnosis. Ann Clin Biochem. 2007;44 (Pt 4): 321–3.

Fernández C Giménez M Díaz G Conget I . Accuracy and predictive value of classification schemes for ketosis-prone diabetes. Diabetes Care. 2007;30 (9): e96.

Cerna M Kolostova K Novota P Romzova M Cejkova P Pinterova D Pruhova S Treslova L Andel M . Autoimmune diabetes mellitus with adult onset and type 1 diabetes mellitus in children have different genetic predispositions. Ann N Y Acad Sci. 2007;1110: 140–50.

Frayling TM . Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet. 2007;8: 657–62.

Petersen KF Shulman GI . Etiology of insulin resistance. Am J Med. 2006;119 (5 Suppl 1): S10–6.

Reitman ML Schadt EE . Pharmacogenetics of metformin response: a step in the path toward personalized medicine. J Clin Invest. 2007;117 (5): 1226–9.

Hattersley AT Pearson ER . Minireview: pharmacogenetics and beyond: the interaction of therapeutic response, beta-cell physiology, and genetics in diabetes. Endocrinology. 2006;147: 2657–63.

Holmkvist J Almgren P Lyssenko V lindgren CM Eriksson KF Isomaa B Tuomi T Nilsson P Groop L . Common variants in MODY genes and future risk of type 2 diabetes. Diabetes. 2008 Mar 10.

Rutter GA . Generating new candidate genes for neonatal diabetes: functional and genetic studies of insulin secretion in type 2 diabetes. Endocr Dev. 2007;12: 75–85.

Kaput J Dawson K . Complexity of type 2 diabetes mellitus data sets emerging from nutrigenomic research: a case for dimensionality reduction? Mutat Res. 2007;622 (1–2): 19–32.

Genuth S . Insights from the diabetes control and complications trial/epidemiology of diabetes interventions and complications study on the use of intensive glycemic treatment to reduce the risk of complications of type 1 diabetes. Endocr Pract. 2006;12 Suppl 1: 34–41.

Bresson D von Herrath M .Moving towards efficient therapies in type 1 diabetes: to combine or not to combine? Autoimmun Rev. 2007;6 (5): 315–22.

Zaia JA . The status of gene vectors for the treatment of diabetes. Cell Biochem Biophys. 2007;48: 183–90.

Leiter LA . Can thiazolidinediones delay disease progression in type 2 diabetes? Curr Med Res Opin. 2006;22: 1193–201.

Gerstein HC Rosenstock J . Insulin therapy in people who have dysglycemia and type 2 diabetes mellitus: can it offer both cardiovascular protection and beta-cell preservation? Endocrinol Metab Clin North Am. 2005;34: 137–54.

Brophy S Brunt H Davies H Mannan S Williams R . Interventions for latent autoimmune diabetes (LADA) in adults. Cochrane Database Syst Rev. 2007;18: CD006165.

Balasubramanyam A Garza G Rodriguez L Hampe CS Gaur L Lernmark A Maldonado MR . Accuracy and predictive value of classification schemes for ketosis-prone diabetes. Diabetes Care. 2006;29 (12): 2575–9.

Timsit J Bellanné-Chantelot C Dubois-Laforgue D Velho G . Diagnosis and management of maturity-onset diabetes of the young. Treat Endocrinol. 2005;4: 9–18.

Polak M Cavé H . Neonatal diabetes mellitus: a disease linked to multiple mechanisms. Orphanet J Rare Dis. 2007;2: 12.

Nield L Moore HJ Hooper L Cruickshank JK Vyas A Whittaker V Summerbell CD . Dietary advice for treatment of type 2 diabetes mellitus in adults. Cochrane Database Syst Rev. 2007 Jul 18;CD004097.

Praet SF van Loon LJ . Optimizing the therapeutic benefits of exercise in Type 2 diabetes. J Appl Physiol. 2007;103: 1113–20.

Isermann B Ritzel R Zorn M Schioling T Nawroth PP . Autoantibodies in diabetes mellitus: current utility and perspectives. Exp Clin Endocrinol Diabetes. 2007;115: 483–90.

Hinke SA . Finding GAD: early detection of beta-cell injury. Endocrinology. 2007;148: 4568–71.

Vrabelova Z Kolouskova S Böhmova K Faresjö MK Sumnik Z Pechova M Kverka M Chudoba D Zacharovova K Stadlerova G Pithova P Hladikova M Stechova K . Protein microarray analysis as a tool for monitoring cellular autoreactivity in type 1 diabetes patients and their relatives. Pediatr Diabetes. 2007;8: 252–60.

Wang X Jia S Geoffrey R Alemzadeh R Ghosh S Hessner MJ . Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics. J Immunol. 2008;180: 1929–37.

Gadi R Samaha FF . Dyslipemia in type 2 diabetes mellitus. Curr Diab Rep. 2007;7: 228–34.

Mikhailidis DP Press M . The importance of treating multiple cardiometabolic risk factors in patients with Type 2 diabetes. Expert Opin Pharmacother, 2007;8: 3009–20.

Alexandraki K Piperi C Kalofoutis C Singh J Alaveras A Kalofoutis A . Inflammatory process in type 2 diabetes: the role of cytokines. Ann N Y Acad Sci. 2006;1084: 89–117.

Wolf G . Serum retinol-binding protein: a link between obesity, insulin resistance, and type 2 diabetes. Nutr Rev. 2007;65: 251–6.

Signorelli SS Massarino MC Spandidos DA Malaponte G . Proinflammatory circulating molecules in peripheral arterial disease. Int J Mol Med. 2007;20: 279–86.

Monnier L Mas E Ginet C Michel F Villon L Cristol JP Colette C . Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006;295: 1681–7.

Gerrits EG Lutgers HL Kleefstra N Graaff R Groenier KH Smit AJ Gans RO Bilo HJ . Skin autofluorescence: a tool to identify type 2 diabetic patients at risk for developing microvascular complications. Diabetes Care. 2008;31 (3): 517–21.

Dungan KM . 1,5-anhydroglucitol (GlycoMark) as a marker of short-term glycemic control and glycemic excursions. Expert Rev Mol Diagn. 2008;8: 9–19.

Takahashi S Uchino H Shimizu T Kanazawa A Tamura Y Sakai K Watada H Hirose T Kawamori R Tanaka Y . Comparison of glycated albumin (GA) and glycated hemoglobin (HbA1c) in type 2 diabetic patients: usefulness of GA for evaluation of short-term changes in glycemic control. Endocr J. 2007;54 (1): 139–44.

Novak BJ Blake DR Meinardi S Rowland FS Pontello A Cooper DM Galassetti PR . Exhaled methyl nitrate as a noninvasive marker of hyperglycemia in type 1 diabetes. Proc Natl Acad Sci U S A. 2007;104: 15613–8.

Nguyen HT Ghevondian N Nguyen ST Jones TW . Detection of hypoglycemic episodes in children with type 1 diabetes using an optimal Bayesian neural network algorithm. Conf Proc IEEE Eng Med Biol Soc. 2007;1: 3140–3.

Pandian PS Mohanavelu K Safeer KP Kotresh TM Shakunthala DT Gopal P Padaki VC . Smart Vest: Wearable multi***parameter remote physiological monitoring system. Med Eng Phys. 2007 Sep 12.

Axisa F Gehin C Delhomme G Collet C Robin O Dittmar A . Wrist ambulatory monitoring system and smart glove for real time emotional, sensorial and physiological analysis. Conf Proc IEEE Eng Med Biol Soc. 2004;3: 2161–4.

Ludvigsson J . Immune intervention at diagnosis—should we treat children to preserve beta-cell function? Pediatr Diabetes. 2007;8 Suppl 6: 34–9.

Klonoff DC . Continuous glucose monitoring: roadmap for 21st century diabetes therapy. Diabetes Care. 2005;28: 1231–9.

White RD . Insulin pump therapy (continuous subcutaneous insulin infusion). Prim Care. 2007;34: 845–71.

Klonoff D . The artificial pancreas: how sweet engineering will solve bitter problems. J Diabetes Sci Technol. 2007;1: 72–81.

Bastard JP Maachi M Lagathu C Kim MJ Caron M Vidal H Capeau J Feve B . Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006;17: 4–12.

Mikhailidis DP Press M . The importance of treating multiple cardiometabolic risk factors in patients with Type 2 diabetes. Expert Opin Pharmacother. 2007;8: 3009–20.

Hutchison CA 3rd . DNA sequencing: bench to bedside and beyond. Nucleic Acids Res. 2007;35: 6227–37.

Bottinger EP . Foundations, promises and uncertainties of personalized medicine. Mt Sinai J Med. 2007;74: 15–21.

Solomon LM Sieczkiewicz GJ . Impact of the US Patent System on the promise of personalized medicine. Gend Med. 2007;4: 187–92.

Fox JL . Despite glacial progress, US government signals support for personalized medicine. Nat Biotechnol. 2007;25: 489–90.

Brenner SE . Common sense for our genomes. Nature. 2007;449: 783–4.

Klein TE Chang JT Cho MK Easton KL Fergerson R Hewett M Lin Z Liu Y Liu S Oliver DE Rubin DL Shafa F Stuart JM Altman RB . Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. Pharmacogenomics J. 2001;1: 167–70.