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Abstract

Aim/Objections

The purpose of this study was to assess the efficacy of a central line maintenance bundle in preventing catheter-related (implanted venous access devices, port) Candida bloodstream infections.

Methods

The study encompassed two distinct time periods, namely, pre-bundle and bundle. The number of catheter-related bloodstream infections (CRBSI) episodes per catheter days for each timeframe was determined.

Findings/Results

Upon implementation of the central line bundle, the rate of CRBSI reduced significantly from 4.27 per 1000 central line days in the pre-bundle period to 1.0 per 1000 central line days in the bundle period (p < .001).

Discussion

Using a central line bundle to avoid CRBSIs in pediatric cancer patients with ports led to a significant decrease in Candida species-related CRBSIs.

Keywords

Candida port catheter-related bloodstream infections bundle

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References

Akbari

Kjellerup

(2015) Elimination of bloodstream infections associated with Candida albicans biofilm in intravascular catheters. Pathogens 4(3): 457–469. DOI: 10.3390/pathogens4030457.

Barrell

Covington

Bhatia

, et al. (2012) Preventive strategies for central line-associated bloodstream infections in pediatric hematopoietic stem cell transplant recipients. American Journal of Infection Control 40(5): 434–439. DOI: 10.1016/j.ajic.2011.06.002.

Devrim

Oruc

Demirag

, et al. (2018) Central line bundle for prevention of central line–associated bloodstream infection for totally implantable venous access devices (ports) in pediatric cancer patients. The Journal of Vascular Access 19(4): 358–365. DOI: 10.1177/1129729818757955.

Devrim

Ozkul

Caglar

, et al. (2020) Central line bundle including split-septum device and single-use prefilled flushing syringes to prevent port-associated bloodstream infections: a cost and resource-utilization analysis. BMC Health Services Research 20(1):336. DOI: 10.1186/s12913-020-05221-6.

Douglas

(2003) Candida biofilms and their role in infection. Trends in Microbiology 11: 30–36. DOI: 10.1016/s0966-842x(02)00002-1.

Gorski

Hadaway

Hagle

, et al. (2021) Infusion therapy standards of practice updates. J Infus Nurs 44(4):189–190. doi: 10.1097/NAN.0000000000000436.

Gowin

Świątek-Kościelna

Mańkowski

, et al. (2020) The profile of microorganisms responsible for port-related bacteremia in pediatric hemato-oncological patients. Cancer Control 27(1): 1073274820904696. DOI: 10.1177/1073274820904696.

Mantadakis

Pana

Zaoutis

(2018) Candidemia in children: epidemiology, prevention and management. Mycoses 61: 614–622. DOI: 10.1111/myc.12792.

Mermel

Allon

Bouza

, et al. (2009) Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clinical Infectious Diseases 49: 1–45. DOI: 10.1086/599376.

10.

O'Grady

Alexander

Burns

, et al. (2011) Healthcare infection control practices advisory committee (HICPAC) (appendix 1). Summary of recommendations: guidelines for the prevention of intravascular catheter-related infections. Clinical Infectious Diseases52(9):1087–1099. DOI: 10.1093/cid/cir138.

11.

Rinke

Chen

Bundy

, et al. (2012) Implementation of a central line maintenance care bundle in hospitalized pediatric oncology patients. Pediatrics 130(4):e996–e1004.

12.

Trofa

Gácser

Nosanchuk

(2008) Candida parapsilosis, an emerging fungal pathogen. Clinical Microbiology Reviews 21: 606–625. DOI: 10.1128/CMR.00013-08.

13.

Vasileiou

Paisiou

Tsipou

, et al. (2020) Candidemia in children with malignancies: report from the infection working group of the hellenic society of pediatric hematology-oncology. J Fungi (Basel) 6(4):276. DOI: 10.3390/jof6040276.

The evaluation of Candida-related central line-related bloodstream infections in pediatric cancer patients: A pre- and post-intervention study