We conducted a pre-intervention/post-intervention study to assess the rate of healthcare-associated Clostridium difficile infections (HA-CDI) before and after the implementation of an antimicrobial stewardship program (ASP). Upon implementation of our ASP, the usage of targeted antimicrobials, including ceftriaxone, clindamycin, fluoroquinolones and carbapenem antibiotics, were significantly reduced. There was also a significant reduction in HA-CDI/1000 patient-days following ASP implementation (0.84 vs. 0.28; P = 0.035).
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MagillSSEdwardsJRBambergWBeldavsZGDumyatiGKKainerMALynfieldRMaloneyMMcAllister-HollodLNadleJRaySMThompsonDLWilsonLEFridkinSKand Emerging Infections Program Healthcare-Associated Infections and Antimicrobial Use Prevalence Survey Team. (2014) Multistate point-prevalence survey of health care-associated infections. New England Journal of Medicine370: 1198–1208.
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WalshTLBremmerDNMoffaMAChan-TompkinsNHMurilloMAChanLBurkittMJKonopkaCIWatsonCTrienskiTL. (2017) Effect of antimicrobial stewardship program guidance on the management of uncomplicated skin and soft tissue infections in hospitalized adults. Mayo Clinic Proceedings: Innovations, Quality & Outcomes1: 91–99.
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WalshTLMoffaMABeanHRWatsonCBremmerD. (in press) Impact of antimicrobial stewardship program guidance on the management of community-acquired pneumonia in hospitalized adults. The Journal of Antimicrobial Stewardship.
