Sequential therapy for Helicobacter pylori eradication: the time is now!

Bourke, B. , Ceponis, P. , Chiba, N. , Czinn, S. , Ferraro, R. , Fischbach, L. et al. (2005) Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents - an evidence-based evaluation. Can J Gastroenterol 19: 399-408.

Blaser, M.J. , Chyou, P.H. and Nomura, A. ( 1995) Age at establishment of Helicobacter pylori infection and gastric carcinoma. gastric ulcer and duodenal ulcer risk, Cancer Res 55: 562-565.

Caselli, M. , Zullo, A. , Maconi, G. , Parente, F. , Alvisi, V. , Casetti, T. et al. (2007) Cervia II Working Group Report 2006: guidelines on diagnosis and treatment of Helicobacter pylori infection in Italy. Dig Liver Dis 39: 782-789.

Choi, W.H. , Park, D.I. , Oh, S.J. , Baek, Y.H. , Hong, C.H. et al. (2008) Effectiveness of 10 day-sequential therapy for Helicobacter pylori eradication in Korea. Korean J Gastroenterol 51: 280-284.

De Francesco, V. , Margiotta, M. , Zullo, A. , Hassan, C. , Troiani, L. , Burattini, O. et al. (2006) Clarithromycin-resistant genotypes and eradication of Helicobacter pylori. Ann Intern Med 144: 94-100.

De Francesco, V. , Zullo, A. , Hassan, C. , Faleo, D. , Ierardi, E. , Panella, C. et al. (2001) Two new treatment regimens for Helicobacter pylori eradication: a randomised study. Dig Liver Dis 33: 676-679.

De Francesco, V. , Della Valle, N. , Stoppino, V. , Amoroso, A. , Muscatiello, N. , Panella, C. et al. (2004a) Effectiveness and pharmaceutical cost of sequential treatment for Helicobacter pylori in patients with non-ulcer dyspepsia. Aliment Pharmacol Ther 19: 993-998.

De Francesco, V. , Zullo, A. , Hassan, C. , Valle, N.D. , Pietrini, L. , Minenna, M.F. et al. (2004b) The prolongation of triple therapy for Helicobacter pylori does not allow reaching therapeutic outcome of sequential scheme: a prospective, randomized study. Dig Liver Dis 36: 322-326.

De Francesco, V. , Zullo, A. , Margiotta, M. , Marangi, S. , Burattini, O. , Berloco, P. et al. (2004c) Sequential treatment for Helicobacter pylori does not share the risk factors of triple therapy failure. Aliment Pharmacol Ther 19: 407-414.

Focareta, R. , Forte, G. , Ciarleglio, A. and Forte, F. ( 2003) Helicobacter pylori eradication: one week triple therapy vs. 10-day sequential regimen. Dig Liver Dis 34(Suppl. 1): A17.

Focareta, R. , Forte, G. and Forte, F. ( 2003) Could the 10-days sequential therapy be considered a first choice treatment for the eradication of Helicobacter pylori infection? Dig Liver Dis 35(Suppl. 4): S33.

Francavilla, R. , Lionetti, E. , Castellaneta, S.P. , Magistà, A.M. , Boscarelli, G. , Piscitelli, D. et al. (2005) Improved efficacy of 10-day sequential treatment for Helicobacter pylori eradication in children: a randomized trial. Gastroenterology 129: 1414-1419.

Francavilla, R. , Lionetti, E. and Cavallo, L. ( 2008) Sequential treatment for Helicobacter pylori eradication in children. Gut 57: 1178 (letter).

Fuccio, L. , Minardi, M.E. , Zagari, R.M. , Grilli, D. , Magrini, N. and Bazzoli, F. ( 2007) Meta-analysis: duration of first-line proton-pump inhibitor based triple therapy for Helicobacter pylori eradication. Ann Intern Med 147: 553-562.

Gatta, L. , Di Mario, F. , Zullo, A. and Vaira, D. ( 2008) Errors in a meta-analysis of treatments for Helicobacter pylori infection. Ann Intern Med 149: 686 (letter).

Gatta, L. , Vakil, N. , Leandro, G. , Di Mario, F. and Vaira, D. ( 2009) Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children. Am J Gastroenterol (in press).

Gumurdulu, Y. , Serin, E. , Özer, B. , Kayaselcuk, F. , Ozsahin, K. et al. (2004) Low eradication rate of Helicobacter pylori with triple 7-14 days and quadruple therapy in Turkey. World J Gastroenterol 10: 668-671.

Hassan, C. , De Francesco, V. , Zullo, A. , Scaccianoce, G. , Piglionica, D. , Ierardi, E. et al. (2003) Sequential treatment for Helicobacter pylori eradication in duodenal ulcer patients: improving the cost of pharmacotherapy . Aliment Pharmacol Ther 18: 641-646.

Huang, J.Q. and Hunt, R.H. ( 1999) Treatment after failure: the problem of ‘non-responders’ . Gut 45: 140-144.

Hurduc, V. , Dragomir, D. , Leseany, G. and Sajin, M. ( 2007) Comparison of sequential and triple therapies in the eradication of H. pylori infection in symptomatic children. Gut 56(Suppl. III): A243.

Jafri, N.S. , Hornung, C.A. and Howden, C.W. ( 2008) Meta-analysis: sequential therapy appears superior to standard therapy for Helicobacter pylori infection in patients naive to treatment . Ann Intern Med 148: 923-931.

Koletzko, S. , Richy, F. , Bontems, P. , Crone, J. , Kalach, N. , Monteiro, M.L. et al. (2006) Prospective multi-centre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe. Gut 55: 1811-1816.

Lamp, K.C. , Freeman, C.D. , Klutman, N.E. and Lacy, M.K. ( 1999) Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials. Clin Pharmacokinet 36: 353-373.

Lerro, P. , Ruvidi, M. , Baldi, M. , Calvo, P.L. and Barbera, C. ( 2006) A 10-day sequential therapy: new option for Helicobacter pylori eradication in children. Dig Liver Dis 38: A104.

Lionetti, E. , Miniello, V.L. , Castellaneta, S.P. , Magistá, A.M. , de Canio, A. , Maurogiovanni, G. et al. (2006) Lactobacillus reuteri therapy to reduce side-effects during anti-Helicobacter pylori treatment in children: a randomized placebo controlled trial. Aliment Pharmacol Ther 24: 1461-1468.

Malfertheiner, P. , Megraud, F. , O’Morain, C. , Bazzoli, F. , El-Omar, E. , Graham, D. et al. (2007) Current concepts in the management of Helicobacter pylori infection - The Maastricht III Consensus Report. Gut 56: 772-781.

Marshall, B. ( 2008) Sequential therapy for Helicobacter pylori: a worthwhile effort for your patients. Ann Intern Med 148: 962-963.

Megraud, F. ( 2004) H. pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut 53: 1374-1384.

Moayyedi, P. ( 2007) Sequential regimens for Helicobacter pylori eradication . Lancet 370: 1010-1012.

Murakami, K. , Fujioka, T. , Okimoto, T. , Sato, R. , Kodama, M. , Nasu, M. et al. (2002) Drug combinations with amoxicillin reduces selection of clarithromycin resistance during Helicobacter pylori eradication therapy. Int J Antimicrob Agents 19: 67-70.

Oderda, G. , Shcherbakov, P. , Bontems, P. , Urruzuno, P. , Romano, C. , Gottrand, F. et al. (2007) Results from the pediatric European register for treatment of Helicobacter pylori (PERTH). Helicobacter 12: 150-156.

Paoluzi, O.A. , Visconti, E. , Andrei, F. , Tosti, C. , Erboso, M. , Lionettti, R. et al. (2008) Sequential regimens have greater efficacy and better tolerability than standard triple therapy in the eradication of Helicobacter pylori infection. Dig Liver Dis 40: S40.

Rinaldi, V. , Zullo, A. , Pugliano, F. , Valente, C. , Diana, F. and Attili, A.F. ( 1997) The management of failed dual or triple therapy for Helicobacter pylori eradication. Aliment Pharmacol Ther 11: 929-933.

Rokkas, T. , Sechopoulos, P. , Robotis, I. , Margantinis, G. and Pistiolas, D. ( 2009) Cumulative H. pylori eradication rates in clinical practice by adopting first and second-line regimens proposed by the Maastricht III Consensus and a third-line empirical regimen. Am J Gastroenterol 104: 21-25.

Ruiz-Obaldia, J.R. , Torrazza, E.G. and Carreno, N.O. ( 2008) Helicobacter pylori eradication with either conventional 10-day triple therapy or 10-day modified sequential regimen. Preliminary report. Gastroenterology 134(Suppl. 1): A24.

Sánchez-Delgado, J. , Calvet, X. , Bujanda, L. , Gisbert, J.P. , Titó, L. and Castro, M. ( 2008) Ten-day sequential treatment for Helicobacter pylori eradication in clinical practice. Am J Gastroenterol 103: 2220-2223.

Scaccianoce, G. , Hassan, C. , Panarese, A. , Piglionica, D. , Morini, S. and Zullo, A. ( 2006) Helicobacter pylori eradication with either 7-day or 10-day triple therapies, and with a 10-day sequential regimen. Can J Gastroenterol 20: 113-117.

Vaira, D. , Zullo, A. , Vakil, N. , Gatta, L. , Ricci, C. , Perna, F. et al. (2007) Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication. A randomized trial. Ann Int Med 146: 556-563.

Vakil, N. , Lanza, F. , Schwartz, H. and Barth, J. ( 2004) Seven-day therapy for Helicobacter pylori in the United States. Aliment Pharmacol Ther 20 99-107.

Wong, B.C.Y. , Lam, S.K. , Wong, W.M. , Chen, J.S. , Zheng, T.T. , Feng, R.E. et al. (2004) Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China. A randomized controlled trial . JAMA 291: 187-194.

Wu, D.C. , Hsu, P.I. , Wu, J.Y. , Opekun, A.R. and Graham, D.Y. ( 2008) Randomized controlled comparison of sequential and quadruple (concomitant) therapies for H. pylori infection. Gastroenterology 134(Suppl. 1): A24.

Zullo, A. , Gatta, L. , De Francesco, V. , Hassan, C. , Ricci, C. , Bernabucci, V. et al. (2005) High rate of Helicobacter pylori eradication with sequential therapy in elderly patients with peptic ulcer: a prospective controlled study. Aliment Pharmacol Ther 21: 1419-1424.

Zullo, A. , Hassan, C. and Campo, S.M.A. ( 2004) Elevata efficacia della terapia sequenziale nel trattamento dell’infezione da Helicobacter pylori. Ospedale e Territorio - Gastroenterologia 5: 87-90.

Zullo, A. , Rinaldi, V. , Winn, S. , Meddi, P. , Lionetti, R. , Hassan, C. et al. (2000) A new highly effective short-term therapy schedule for Helicobacter pylori eradication. Aliment Pharmacol Ther 14: 715-718.

Zullo, A. , Vaira, D. , Vakil, N. , Hassan, C. , Gatta, L. , Ricci, C. et al. (2003) High eradication rates of Helicobacter pylori with a new sequential treatment. Aliment Pharmacol Ther 17: 719-726.

Zullo, A. , De Francesco, V. , Hassan, C. , Panella, C. , Morini, S. and Ierardi, E. ( 2006) Second-line treatment for Helicobacter pylori eradication after sequential therapy failure: a pilot study. Therapy 3: 251-254.

Zullo, A. , De Francesco, V. , Hassan, C. , Morini, S. and Vaira, D. ( 2007) The sequential therapy regimen for Helicobacter pylori eradication. Gut 56: 1353-1357.