Functional gastrointestinal disorders are very common in the Western world, but unfortunately the underlying mechanisms behind these disorders are incompletely understood. Treatment options are limited and the economic consequences for society are profound. Recent data suggest an involvement of bacteria in the pathogenesis of functional gastrointestinal disorders. Probiotics are promising new treatment alternatives, which will be reviewed in this supplement.
Agreus, L., Svärdsudd, K., Nyren, O. and Tibblin, G. (1995) Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology109: 671-680.
2.
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G.S., Santini, D. et al. (2004) Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology126: 693-702.
3.
Camilleri, M., McKinzie, S., Busciglio, I., Low, P.A., Sweetser, S., Burton, D. et al. (2008) Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol6: 772-781.
4.
Chey, W.Y., Jin, H.O., Lee, M.H., Sun, S.W. and Lee, K.Y. (2001) Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea. Am J Gastroenterol96: 1499-1506.
5.
Corsetti, M., Caenepeel, P., Fischler, B., Janssens, J. and Tack, J. (2004) Impact of coexisting irritable bowel syndrome on symptoms and pathophysiological mechanisms in functional dyspepsia. Am J Gastroenterol99: 1152-1159.
6.
Drossman, D.A. (2006) The functional gastrointestinal disorders and the Rome III process. Gastroenterology130: 1377-1390.
7.
Drossman, D.A., Whitehead, W.E., Toner, B.B., Diamant, N., Hu, Y.J., Bangdiwala, S.I. et al. (2000) What determines severity among patients with painful functional bowel disorders? Am J Gastroenterol95: 974-980.
8.
FAO/WHO ( 2001) Health and Nutritional Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria. Report of a Joint FAO/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria.
9.
Ford, M.J., Miller, P.M., Eastwood, J. and Eastwood, M.A. (1987) Life events, psychiatric illness and the irritable bowel syndrome. Gut28: 160-165.
10.
Furrie, E. (2006) A molecular revolution in the study of intestinal microflora. Gut55: 141-143.
11.
Gwee, K.A., Leong, Y.L., Graham, C., Mckendrick, M.W., Collins, S.M., Walters, S.J. et al. (1999) The role of psychological and biological factors in postinfective gut dysfunction. Gut44: 400-406.
12.
Halvorson, H.A., Schlett, C.D. and Riddle, M.S. (2006) Postinfectious irritable bowel syndrome - a meta-analysis . Am J Gastroenterol101: 1894-1899, quiz 1942.
13.
Harvey, R.F., Salih, S.Y. and Read, A.E. (1983) Organic and functional disorders in 2000 gastroenterology outpatients. Lancet1: 632-634.
14.
Hobson, A.R. and Aziz, Q. (2004) Brain imaging and functional gastrointestinal disorders: has it helped our understanding? Gut53: 1198-1206.
15.
Jailwala, J., Imperiale, T.F. and Kroenke, K. (2000) Pharmacologic treatment of the irritable bowel syndrome: a systematic review of randomized, controlled trials. Ann Intern Med133: 136-147.
16.
Kanazawa, M., Palsson, O.S., Thiwan, S.I., Turner, M.J., Van Tilburg, M.A., Gangarosa, L.M. et al. (2008) Contributions of pain sensitivity and colonic motility to IBS symptom severity and predominant bowel habits. Am J Gastroenterol103: 2550-2561.
17.
Kassinen, A., Krogius-Kurikka, L., Makivuokko, H., Rinttila, T., Paulin, L., Corander, J. et al. (2007) The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology133: 24-33.
18.
Lackner, J.M., Mesmer, C., Morley, S., Dowzer, C. and Hamilton, S. (2004) Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis. J Consult Clin Psychol72: 1100-1113.
19.
Levy, R.L., Jones, K.R., Whitehead, W.E., Feld, S.I., Talley, N.J. and Corey, L.A. (2001) Irritable bowel syndrome in twins: heredity and social learning both contribute to etiology. Gastroenterology121: 799-804.
20.
Levy, R.L., Whitehead, W.E., Von Korff, M.R. and Feld, A.D. (2000) Intergenerational transmission of gastrointestinal illness behavior. Am J Gastroenterol95: 451-456.
21.
Longstreth, G.F., Thompson, W.G., Chey, W.D., Houghton, L.A., Mearin, F. and Spiller, R.C. (2006) Functional bowel disorders. Gastroenterology130: 1480-1491.
22.
Maxton, D.G., Morris, J. and Whorwell, P.J. (1991) More accurate diagnosis of irritable bowel syndrome by the use of `non- colonic' symptomatology. Gut32: 784-786.
23.
McFarland, L.V. and Dublin, S. (2008) Meta-analysis of probiotics for the treatment of irritable bowel syndrome. World J Gastroenterol14: 2650-2661.
24.
Mertz, H., Naliboff, B., Munakata, J., Niazi, N. and Mayer, E.A. (1995) Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology109: 40-52.
25.
Moayyedi, P., Ford, A.C., Talley, N.J., Cremonini, F., Foxx-Orenstein, A., Brandt, L. et al. (2008) The efficacy of probiotics in the therapy of irritable bowel syndrome: a systematic review. Gut: [Epub ahead of print].
26.
Naliboff, B.D., Berman, S., Suyenobu, B., Labus, J.S., Chang, L., Stains, J. et al. (2006) Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patients . Gastroenterology131: 352-365.
27.
Ohman, L., Isaksson, S., Lundgren, A., Simrén, M. and Sjövall, H. (2005) A controlled study of colonic immune activity and beta7+ blood T lymphocytes in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol3: 980-986.
28.
Ohman, L. and Simrén, M. (2007) New insights into the pathogenesis and pathophysiology of irritable bowel syndrome. Dig Liver Dis39: 201-215.
29.
Pasricha, P.J. (2007) Desperately seeking serotonin. A commentary on the withdrawal of tegaserod and the state of drug development for functional and motility disorders. Gastroenterology132: 2287-2290.
30.
Piche, T., Barbara, G., Aubert, P., Bruley Des Varannes, S., Dainese, R., Nano, J.L. et al. (2009) Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut58: 196-201.
31.
Posserud, I., Ersryd, A. and Simren, M. (2006) Functional findings in irritable bowel syndrome . World J Gastroenterol12: 2830-2838.
32.
Posserud, I., Stotzer, P.O., Bjornsson, E.S., Abrahamsson, H. and Simren, M. (2007) Small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Gut56: 802-808.
33.
Posserud, I., Syrous, A., Lindstrom, L., Tack, J., Abrahamsson, H. and Simren, M. (2007) Altered rectal perception in irritable bowel syndrome is associated with symptom severity. Gastroenterology133: 1113-1123.
34.
Saito, Y.A., Zimmerman, J.M., Harmsen, W.S., De Andrade, M., Locke 3rd, G.R., Petersen, G.M. et al. (2008) Irritable bowel syndrome aggregates strongly in families: a family-based case-control study. Neurogastroenterol Motil20: 790-797.
35.
Simrén, M., Brazier, J., Coremans, G., Dapoigny, M., Muller-Lissner, S.A., Pace, F. et al. (2004) Quality of life and illness costs in irritable bowel syndrome. Digestion69: 254-261.
36.
Simrén, M., Castedal, M., Svedlund, J., Abrahamsson, H. and Björnsson, E. (2000) Abnormal propagation pattern of duodenal pressure waves in the irritable bowel syndrome (IBS). Dig Dis Sci45: 2151-2161.
37.
Simrén, M., Svedlund, J., Posserud, I., Bjornsson, E.S. and Abrahamsson, H. (2006) Health-related quality of life in patients attending a gastroenterology outpatient clinic: functional disorders versus organic diseases. Clin Gastroenterol Hepatol4: 187-195.
38.
Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P. et al. (2007) Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut56: 1770-1798.
39.
Thompson, C.A. (2001) Alosetron withdrawn from market. Am J Health Syst Pharm58: 13.
40.
Thompson, W.G., Heaton, K.W., Smyth, G.T. and Smyth, C. (2000) Irritable bowel syndrome in general practice: prevalence characteristics, and referral. Gut46: 78-82.
41.
Vandvik, P.O., Lydersen, S. and Farup, P.G. (2006) Prevalence, comorbidity and impact of irritable bowel syndrome in Norway. Scand J Gastroenterol41: 650-656.
Whitehead, W.E., Crowell, M.D., Robinson, J.C., Heller, B.R. and Schuster, M.M. (1992) Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction. Gut33: 825-830.