Over the past few decades, healthcare of people with an intellectual disability (ID) has drastically improved. Unfortunately, their average life expectancy is still substantially lower than the general population. Ageing in this vulnerable group is complex and can be accelerated depending on the underlying genetic condition associated with their disability. Despite this, they still experience the same age-related chronic diseases as the general population, but their health needs can go unidentified and unmet. This can lead to delayed diagnosis and poorer outcomes. The importance of identifying illness early and involving specialist ID teams to address their unique needs is key to improving management and prognosis.
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References
1.
AliABrownETsangW, et al. (2022)
Individual cognitive stimulation therapy (iCST) for people with intellectual disability and dementia: a feasibility randomised controlled trial. Aging Mental Health26(4): 698–708. doi: 10.1080/13607863.2020.1869180.
2.
AliNSohailRJafferS, et al. (2023)
The role of estrogen therapy as a protective factor for alzheimer’s disease and dementia in postmenopausal women: a comprehensive review of the literature. Cureus Journal of Medical Science15(8): e43053. doi:10.7759/cureus.43053
3.
BallardCMobleyWHardyJ, et al. (2016)
Dementia in Down’s syndrome. Lancet Neurology15(6): 622–636. DOI: 10.1016/S1474-4422(16)00063-6.
4.
BratekAKrystaKKuciaK (2017)
Psychiatric comorbidity in older adults with intellectual disability. Psychiatrica Danubina29(Suppl 3): 590–593.
5.
BuchananLH (1990)
Early onset of presbyacusis in Down syndrome. Scandinavian Audiology19(2): 103–110. doi: 10.3109/01050399009070760
6.
CassidySBSchwartzSMillerJLDriscollDJ (2012)
Prader–Willi syndrome. Genetics in Medicine14(1): 10–26. doi: 10.1038/gim.0b013e31822bead0.
7.
CosgraveMPTyrrellJMcCarronMGillMLawlorBA (1999)
Age at onset of dementia and age of menopause in women with Down’s syndrome. Journal of Intellectual Disabilities Research43(6): 461–465. doi: 10.1046/j.1365-2788.1999.00192.x.
8.
DouglasIJSmeethL (2008)
Exposure to antipsychotics and risk of stroke: self controlled case series study. BMJ337: a1227. doi: 10.1136/bmj.a1227.
9.
DykensE (2013)
Aging in rare intellectual disability syndromes. Developmental Disabilities Research Reviews18(1): 75–83. doi: 10.1002/ddrr.1130. PMID: 23949831.
10.
EinfeldSLKavanaghSJSmithAEvansEJTongeBJTaffeJ (2006)
Mortality in Prader–Willi syndrome. American Journal on Mental Retardation111(3): 193–198. doi: 10.1352/0895-8017(2006)111[193:MIPS]2.0.CO;2.
11.
El MrayyanNHolmgrenMAhlströmG (2025)
Healthy ageing for older adult people with intellectual disability: a scoping review. Archives of Public Health83: 55. DOI: 10.1186/s13690-025-01528-0
12.
FlynnSHulbert-WilliamsNJHulbert-WilliamsLBramwellR (2016)
“You don’t know what’s wrong with you”: An exploration of cancer-related experiences in people with an intellectual disability. Psycho-Oncology25(10): 1198–1205. DOI:10.1002/pon.4211
13.
GarberKBVisootsakJWarrenST (2008)
Fragile X syndrome. European Journal of Human Genetics16(6): 666–672. doi: 10.1038/ejhg.2008.61.
GomezWMoralesRMaracaja-CoutinhoVParraVNassifM (2020)
Down syndrome and Alzheimer’s disease: common molecular traits beyond the amyloid precursor protein. Aging (Albany NY)12(1): 1011–1033. doi:10.18632/aging.102677
16.
HeslopPBlairPFlemingPHoghtonMMarriottARussL (2014)
The Confidential Inquiry into premature deaths of people with intellectual disabilities in the UK: a population-based study. Lancet383(9920): 889–895. doi: 10.1016/S0140-6736(13)62026-7.
17.
KirkendallALintonKFarrisS (2017)
Intellectual disabilities and decision making at end of life: a literature review. Journal of Applied Research in Intellectual Disabilities: JARID30(6): 982–994. DOI: 10.1111/jar.12270
18.
LiZZhangZRenY, et al. (2021)
Aging and age-related diseases: from mechanisms to therapeutic strategies. Biogerontology22(2): 165–187. doi: 10.1007/s10522-021-09910-5.
19.
McCarthyMMillardL (2003)
Discussing the menopause with women with learning disabilities. British Journal of Learning Disabilities31: 9–17. DOI: 10.1046/j.1468-3156.2003.00182.x
20.
MooreKReidyMForanS (2023)
Understanding the menopausal experiences of women with intellectual disabilities: a scoping review. Journal of Intellectual Disabilities17446295231182246. doi: 10.1177/17446295231182246.
NICE (2016) Mental health problems in people with learning disabilities: Prevention, assessment and management. Available at: www.nice.org.uk/guidance/ng54 (accessed 8 July 2025).
23.
NICE (2018) Care and support of people growing older with learning disabilities www.nice.org.uk/guidance/ng96 (accessed 8 July 2025).
SchupfNZigmanWKapellDLeeJHKlineJLevinB (1997)
Early menopause in women with Down’s syndrome. Journal of Intellectual Disability Research41(3): 264–267. doi: 10.1111/j.1365-2788.1997.tb00706.x.
27.
SeltzerGBSchupfNWuHS (2001)
A prospective study of menopause in women with Down’s syndrome. Journal of Intellectual Disability Research45: 1–7. DOI: 10.1111/j.1365-2788.2001.00286.x
28.
SinaiABohnenIStrydomA (2012)
Older adults with intellectual disability. Current Opinion in Psychiatry25(5): 359–64. doi: 10.1097/YCO.0b013e328355ab26.
29.
StrydomAChanTKingMHassiotisALivingstonG (2013)
Incidence of dementia in older adults with intellectual disabilities. Research in Developmental Disabilities34(6): 1881–1885. doi: 10.1016/j.ridd.2013.02.021.
30.
StrydomARomeoRPerez-AchiagaN, et al. (2010)
Service use and cost of mental disorder in older adults with intellectual disability. British Journal of Psychiatry196(2): 133–138. doi: 10.1192/bjp.bp.108.060939.
31.
UtariAAdamsEBerry-KravisE, et al. (2010)
Aging in fragile X syndrome. Journal of Neurodevelopmental Disorders2(2): 70–76. doi: 10.1007/s11689-010-9047-2.
32.
ValenzuelaMJSachdevP (2006)
Brain reserve and cognitive decline: a non-parametric systematic review. Psychological Medicine36(8): 1065–73. doi: 10.1017/S0033291706007744.
33.
WhiteASheehanRDingJ, et al. (2022) LeDeR Annual Report, Learning from Lives and Deaths:people with a learning disability and autistic people. Available at: www.kcl.ac.uk/ioppn/assets/fans-dept/leder-2022-v2.0.pdf (accessed 8 July 2025).
