Patients with asthma and chronic obstructive pulmonary disease (COPD) make up a significant proportion of the GP workload. The overlap between the two can be described as the asthma COPD overlap syndrome (ACOS). This article describes the clinical and pathological features of ACOS, why it is important to identify and treat it differently and how this might change in the future.
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References
1.
BarrechegurenM.EsquinasC.MiravitllesM. (2015) The asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS): Opportunities and challenges. Current Opinion in Pulmonary Medicine21(1): 74–79. doi: 10.1097/MCP.0000000000000118.
2.
BrutscheM.DownsS.SchindlerC.GerbaseM.SchwartzJ.FreyM.LeuenbergerP. (2006) Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA Cohort Study. Thorax61: 671–677. doi: 10.1136/thx.2005.052241.
3.
GibsonP.SimpsonJ. (2009) The overlap syndrome of asthma and COPD: What are its features and how important is it?Thorax64: 728–735. doi: 10.1136/thx.2008.108027.
HardinM.ChoM.McDonaldM.-L.BeatyT.RamsdellJ.BhattS.HershC.P. (2014) The clinical and genetic features of asthma – COPD-asthma overlap syndrome. European Respiratory Journal44(2): 341–350. doi: 10.1183/09031936.00216013.
6.
IwamotoH.GaoJ.KoskelaJ.KinnulaV.KobayashiH.LaitinenT.MazurW. (2014) Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap. European Respiratory Journal43(2): 421–429. doi: 10.1183/09031936.00024313.
7.
MenezesA.de OcaM.Perez-PadillaR.NadeauG.WehrmeisterC.Lopez-VarelaM.TálamoC. (2014) Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype COPD-asthma. Chest145(2): 297–304. doi: 10.1378/chest.13-0622.
VanfleterenL.KocksJ.StoneI.Breyer-KohansalR.GreulichT.LacedoniaD.AgustiA. (2014) Moving from the Oslerian paradigm to the post- genomic era: Are asthma and COPD outdated terms?Thorax69: 72–79. doi: 10.1136/thoraxjnl-2013-203602.
13.
ZekiA.SchivoM.ChanA.AlbertsonT.LouieS. (2011) The asthma-COPD overlap syndrome: A common clinical problem in the elderly. Journal of Allergy. , 2011, Article ID 861926, 1–10. doi: 10.1155/2011/861926.
