In this paper, we discuss the Bile Acid Comparison and Harmonisation project, a sub-study of the Trial of URsodeoxycholic acid vs RIFampicin in early-onset severe Intrahepatic Cholestasis of pregnancy, giving an overview of the current state of affairs for total bile acid measurements.
MarkusCCoatSMarschallH-U, et al.The BACH project protocol: an international multicentre total bile acid comparison and harmonisation project and sub-study of the TURRIFIC randomised trial. Clinical Chemistry and Laboratory Medicine (CCLM)2021; 59: 1921–1929.
2.
DaneseESalvagnoGNegriniD, et al.Analytical evaluation of three enzymatic assays for measuring total bile acids in plasma using a fully-automated clinical chemistry platform. PLoS One2017; 12: e0179200.
3.
MarkusCCoatSMarschallH-U, et al.Lot-to-lot reagent changes and commutability of quality testing materials for total bile acid measurements. Clin Chem Lab Med2023; 61: e108–e111.
4.
OvadiaCSeedPSklavounosA, et al.Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. Lancet2019; 393: 899–909.
5.
ZhangSChengFWangH, et al.Comparability of thyroid-stimulating hormone immunoassays using fresh frozen human sera and external quality assessment data. PLoS One2021; 16: e0253324.
6.
LittleRRohlfingCSacksD. The NGSP: over 20 years of improving HbA1c measurement. Clin Chem2019 July; 65: 839–848.
