Intensive Care Foundation Research Gold Medal Award Presentations

Intensive Care National Audit and Research Centre. Number of admissions, unit length of stay and days of mechanical ventilation for admissions with blunt chest trauma to critical care in England, Wales and Northern Ireland. 2012. ICNARC.

Battle CE Hutchings H Evans PA . Risk factors that predict mortality in patients with blunt chest wall trauma: A systematic review and meta-analysis. Injury 2012;43: 8–17.

Blecher GE Mitra B Cameron PA Fitzgerald M . Failed emergency department disposition to the ward of patients with thoracic injury. Injury 2008;39: 586–91.

Battle CE Hutchings HA Evans PA . Blunt chest wall trauma: a review. Trauma 2013, in press. DOI/:10.1177/1460408613488480tra.sagepub.com (commissioned paper).

Alexander JQ Gutierrez CJ Mariano MC . Blunt chest trauma in the elderly patient: How cardiopulmonary disease affects outcome. Am Surg 2000;66: 854–57.

Simon BJ Chu Q Emhoff TA . Delayed haemothorax after blunt thoracic trauma: an uncommon entity with significant morbidity. J Trauma 1998;45: 673–76.

Dubinsky I Low A . Non-life threatening blunt chest trauma: appropriate investigation and treatment. Am J Emerg Med 1997;15: 240–43.

Moons KGM Altman DG Vergouwe Y Royston P . Prognosis and prognostic research: application and impact of prognostic models in clinical practice. BMJ 2009;338: 1487–90.

Battle CE Hutchings H Evans PA . Expert opinion of the risk factors for morbidity and mortality in blunt chest wall trauma: Results of a national postal questionnaire survey in the United Kingdom. Injury 2013;44: 56–59.

Battle CE Hutchings H James K Evans PA . The risk factors for the development of complications during the recovery phase following blunt chest wall trauma: a retrospective study. Injury. In press. http://dx.doi.org/10.1016/j.injury.2012.05.019.

Battle CE Hutchings H Evans PA . Outcomes in older blunt chest wall trauma patients: a retrospective study. Crit Care 2012;16 (Suppl): P453.

Battle C Hutchings H Evans PA . Blunt chest wall trauma and outcomes in patients with chronic lung disease: a retrospective study. (Abstract in Trauma Care International Conference 2012). Trauma 2012;14: 359–68.

Battle CE Hutchings H Lovett S Evans PA . Risk factors for the development of complications following blunt chest trauma: a new prognostic model. Crit Care 2013;17(Suppl 2): P292.

Battle CE James K Hepburn D . An evidence-based guideline for the safe triage of chest wall injuries: a pilot study. Br J Surg 2008;95(S3):178.

NICE. Acutely ill patients in hospital: recognition of and response to acute illness in adults in hospital. NICE Clinical Gudelines. 2007;50: 1–07.

Cullinane M Findlay G Hargraves C . An Acute Problem?: A Report of the National Confidential Enquiry Into Patient Outcome and Death [Internet]. NCEPOD; 2005. Available from: http://www.ncepod.org.uk/2005aap.htm.

NPSA. Patient Safety First. patientsafetyfirst.nhs.uk. National Patient Safety Agency; 2011.

Jones DA DeVita MA Bellomo R . Rapid-response teams. N Engl J Med 2011;365: 139–46.

Royal College of Physicians. National Early Warning Score (NEWS): Standardising the assessment of acute-illness severity in the NHS [Internet]. 2012 pp. 1–30. Available from: http://www.rcplondon.ac.uk/resources/national-early-warning-score-news.

Simchen E Sprung CLLC Galai N . Survival of critically ill patients hospitalized in and out of intensive care. Crit Care Med 2007;35: 449–57.

Hutchings A Durand MA Grieve R . Evaluation of modernisation of adult critical care services in England: time series and cost effectiveness analysis. BMJ 2009;339: b4353.

Baillie JK Barnett MW Upton KR . Somatic retrotransposition alters the genetic landscape of the human brain. Nature 2011;479: 534–37.

Sabeti PC Varilly P Fry B . Genome-wide detection and characterization of positive selection in human populations. Nature 2007;449: 913–18.

Horby P Nguyen NY Dunstan SJ Baillie JK . The role of host genetics in susceptibility to influenza: a systematic review. PLoS ONE 2012;7: e33180.

Albright FS Orlando P Pavia AT . Evidence for a heritable predisposition to death due to influenza. J Infect Dis 2008;197: 18–24.

Miller E Hoschler K Hardelid P . Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study. Lancet 2010;375: 1100–08.

Rowan KM Harrison DA Walsh TS . The Swine Flu Triage (SwiFT) study: development and ongoing refinement of a triage tool to provide regular information to guide immediate policy and practice for the use of critical care services during the H1N1 swine influenza pandemic. Health Technol Assess 2010;14: 335–492.

Sorensen T Nielsen G Andersen P Teasdale T . Genetic and environmental influences on premature death in adult adoptees. N Engl J Med 1988;318: 727–32.

Forrest A Hideya K Rehli M Baillie JK . In press.

Everitt AR Clare S Pertel T . IFITM3 restricts the morbidity and mortality associated with influenza. Nature 2012;484: 519–23.

Zhang Y-H Zhao Y Li N . Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun 2013;4: 1418.

Shukla R Upton KR Muñoz-Lopez M . Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. Cell 2013;153: 101–11.

Baillie JK Digard P . Influenza – time to target the host? N Engl J Med 2013;369: 191–93.

Hotchkiss RS Karl IE , The pathophysiology and treatment of sepsis. N Engl J Med 2003;348: 138–50.

Cavaillon JM Annane D . Compartmentalization of the inflammatory response in sepsis and SIRS. J Endotoxin Res 2006;12: 151–70.

Liese AM . Augmented TNF-alpha and IL-10 production by primed human monocytes following interaction with oxidatively modified autologous erythrocytes. J Leukoc Biol 2001;70: 289–96.

Black RA . A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature 1997;385: 729–33.

Scott AJ . Reactive oxygen species and p38 MAPK mediate TNF-alpha converting enzyme (TACE/ADAM17) activation in primary human monocytes. J Biol Chem 2011;286: 35466–76.

Scheller J . ADAM17: a molecular switch to control inflammation and tissue regeneration. Trends Immunol 2011;32: 380–87.

Volk HD . Monocyte deactivation—rationale for a new therapeutic strategy in sepsis. Intensive Care Med 1996;22 Suppl 4: S474–81.

Alvarez-Iglesias M . Continuous real-time measurement of tumor necrosis factor-alpha converting enzyme activity on live cells. Lab Invest 2005;85: 1440–48.