Intracranial pressure monitoring with protocol-based management did not improve outcomes following severe traumatic brain injury compared to treatment based on imaging and clinical assessment.
Level of evidence: 1B− (an individual randomised controlled trial with wide confidence intervals)
References
1.
SterneJAWhiteIRCarlinJB. Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls. BMJ2009;338: b2393.
2.
FullerGPattaniHYeomanP. The Nottingham Head Injury Register: a survey of 1,276 adult cases of moderate and severe traumatic brain injury in a British neurosurgery centre. JICS2007;12: 29–36.
3.
HyamJAWelchCAHarrisonDAMenonDK. Case mix, outcomes and comparison of risk prediction models for admission to adult, general and specialist critical care units for head injury: a secondary analysis of the ICNARC case mix programme database. Crit Care2006;10: S2–11.
4.
MurrayLSTeasdaleGMMurrayGD. Head Injuries in four British neurosurgical centres. Br J Neurosurgery1999;13: 564–69.
5.
AtkinsDBestDBrissPA. Grading quality of evidence and strength of recommendations. BMJ2004;328: 1490.
