ICS Gold Medal and Winning Abstract Presentations

Angus DC Carlet J . Surviving intensive care: a report from the 2002 Brussels Roundtable. Intensive Care Med 2003;29: 368–77.

Desai SV Law TJ Needham DM . Long-term complications of critical care. Crit Care Med 2011;39: 371–79.

Lone NI Walsh TS . Impact of intensive care unit organ failures on mortality during five-years following critical illness. Am J Respir Crit Care Med 2012. [Epub ahead of print].

Williams TA Dobb GJ Finn JC . Determinants of long-term survival after intensive care. Crit Care Med 2008;36: 1523–30.

Zaren B Bergstrom R . Survival compared to the general population and changes in health status among intensive care patients. Act Anaes Scand 1989;33: 6–12.

Niskanen M Kari A Halonen P . Five-year survival after intensive care-comparison of 12,180 patients with the general population. Finnish ICU Study Group. Crit Care Med 1996;24: 1962–67.

Wright JC Plenderleith L Ridley SA . Long-term survival following intensive care: subgroup analysis and comparison with the general population. Anaesthesia 2003;58: 637–42.

Lone NI Seretny M Rowan KM . Surviving intensive care: a systematic review of healthcare resource use after hospital discharge. (Abstract) J Epidemiol Community Health 2010;64: A53.

Walsh TS Garrioch M Maciver C . Audit of Transfusion in Intensive Care in Scotland Study Group. Red cell requirements for intensive care units adhering to evidence-based transfusion guidelines. Transfusion 2004;44: 1405–11.

Lone NI Haddow C Dobbie R . Long-term mortality following ICU admission: a national data linkage cohort study. Abstract submitted for ICS State of the Art meeting 2012.

Lone NI Rowan KM Walsh TS . The effect of socioeconomic status on mortality in the critically ill: a national data linkage study. (Abstract) J Epidemiol Community Health 2011;65: A24.

Lone NI Haddow C Dobbie R . Major healthcare resource use in the five-years following ICU admission: a national data linkage cohort study. Abstract submitted for ICS State of the Art meeting 2012.

Matthay MA Clerici C Saumon G . Lung edema clearance: 20 years of progress: invited review: Active fluid clearance from the distal air spaces of the lung. J Appl Physiol 2002;93: 1533–41.

Knowles MR Carson JL Collier AM . Measurement of nasal transepithelial electrical potential differences in normal human subjects in vivo. Am Rev Respir Dis 1981;124: 484–90.

Egli M Duplain H Lepori M . Defective respiratory amiloride-sensitive sodium transport predisposes to pulmonary oedema and delays its resolution in mice. J Physiol 2004;560: 857–65.

De Boeck K Derichs N Fajac I . New clinical diagnostic procedures for cystic fibrosis in Europe. J Cyst Fibros 2011;10: S53–S66.

Sartori C Allemann Y Duplain H . Salmeterol for the prevention of high-altitude pulmonary edema. N Engl J Med 2002;346: 1631–36.

Barker PM Gowen CW Lawson EE Knowles MR . Decreased sodium ion absorption across nasal epithelium of very premature infants with respiratory distress syndrome. J Pediatr 1997;130: 373–77.

Mac Sweeney R Fischer H McAuley DF . Nasal potential difference to detect Na⁺ channel dysfunction in acute lung injury. Am J Physiol Lung Cell Mol Physiol 2011;300: L305–L318.

Mac Sweeney R Davies JC Parker M . Transepithelial nasal potential difference measurement predicts the development of acute lung injury. Am J Respir Crit Care Med 2012;185: A1146.

Matthay MA Brower RG Carson S . Randomized, placebo-controlled clinical trial of an aerosolized beta-2 agonist for treatment of acute lung injury. Am J Respir Crit Care Med 2011;184: 561–68.

Smith FG Perkins GD Gates S . Effect of intravenous β-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial. Lancet 2012;379: 229–35.

Van Gestel A Bakker J Veraart CP van Hout BA . Prevalence and incidence of severe sepsis in Dutch intensive care units. Crit Care 2004;8: R153–62.

White M Martin-Loeches I Lawless MW . Hospital-acquired pneumonia after lung resection surgery is associated with characteristic cytokine gene expression. Chest 2011;139: 626–32.

Arozullah AM Khuri SF Henderson WG Daley J . Development and validation of a multifactorial risk index for predicting postoperative pneumonia after major non cardiac surgery. Ann Intern Med 2001;135: 847–57.

Khuri SF Henderson WG DePalma RG . Determinants of long term survival after major surgery and the adverse effect of post operative complications. Ann Surg 2005;242: 326–43.

Thomas L . Germs. N Engl J Med 1972;287: 553–55.

Bone RC Balk RA Cerra FB . Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101: 1644–55.

Stone R . Search for sepsis drugs goes on despite past failures. Science 1994;264: 365–67.

Warren HS . Strategies for the treatment of sepsis. N Engl J Med 1997;336: 952–53.

Abraham E Glauser M P Butler T . p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group. JAMA 1997;277: 1531–38.

Fisher CJ Jr Opal SM Dhainaut JF . Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group. Crit Care Med 1993;21: 318–27.

Fisher CJ Jr Agosti JM Opal SM . Treatment of septic shock with the tumor necrosis factor receptor: Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med 1996;334: 1697–702.

Bernard GR Wheeler AP Russell JA . The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med 1997;336: 912–18.

Bone RC Fisher CJ Jr Clemmer TP . A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987;317: 653–58.

Fisher CJ Jr Slotman GJ Opal SM . Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: a randomized, open-label, placebo-controlled multicenter trial. Crit Care Med 1994;22: 12–21.

Ziegler EJ Fisher CJ Jr Sprung CL . Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo controlled trial. The HA-1A Sepsis Study Group. N Engl J Med 1991;324: 429–36.

Sprung CL Annane D Keh D . Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008;358: 111–24.

Murphey ED Lin CY McGuire RW . Diminished bacterial clearance is associated with decreased IL-12 and interferon-gamma production but a sustained proinflammatory response in a murine model of postseptic immunosuppression. Shock 2004;21: 415–25.

Ono S Ueno C Aosasa S . Severe sepsis induces deficient interferon-gamma and interleukin-12 production, but interleukin-12 therapy improves survival in peritonitis. Am J Surg 2001;182: 491–97.

Goebel A Kavanagh E Lyons A . Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection. Ann Surg 2000;231: 253–61.

Nakos G Malamou-Mitsi VD Lachana A . Immunoparalysis in patients with severe trauma and the effect of inhaled interferon-gamma. Crit Care Med 2002;30: 1488–94.

Rigato O Salomao R . Impaired production of interferon-gamma and tumor necrosis factor-alpha but not of interleukin 10 in whole blood of patients with sepsis. Shock 2003;19: 113–16.

Docke WD Randow F Syrbe U . Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 1997;3: 678–81.

Nakos G Malamou-Mitsi VD Lachana A . Immunoparalysis in patients with severe trauma and the effect of inhaled interferon-gamma. Crit Care Med 2002;30: 1488–94.

Tidswell M Tillis W Larosa SP . Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis. Crit Care Med 2010;38: 72–83.

Meisel C Schefold JC Pschowski R . Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double blind, randomised, placebo-controlled multicenter trial. Am J Respir Crit Care Med 2009;180: 640–48.

Duggan E Caraher E Gately K . Tumor necrosis factor-alpha and interleukin-10 gene expression in peripheral blood mononuclear cells after cardiac surgery. Crit Care Med 2006;34: 2134–39.

Ryan R Thornton J Duggan E . Gene polymorphism and requirement for vasopressor infusion after cardiac surgery. Ann Thorac Surg 2006;82: 895–901.

Duggan E O'Dwyer MJ Caraher E . Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism. Anesth Analg 2007;104: 1343–47.

O'Dwyer MJ Dempsey F Crowley V . Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study. Crit Care 2006;10: R139.

O'Dwyer MJ Mankan AK Stordeur P . The occurrence of severe sepsis and septic shock are related to distinct patterns of cytokine gene expression. Shock 2006;26: 544–50.

O'Dwyer MJ Mankan AK White M . The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression. Intensive Care Med 2008;34: 683–91.

White M Lawless MW O'Dwyer MJ . Transforming growth factor beta-1 and interleukin-17 gene transcription in peripheral blood mononuclear cells and the human response to infection. Cytokine 2010;50: 322–27.

O'Dwyer MJ Ryan T . The “cytoscore” predicts survival in severe sepsis. Intensive Care Med 2008;34: S196.

O'Dwyer MJ Ryan AW Mankan AK . Characterisation of tumor necrosis factor-alpha genetic variants influencing gene expression in patients with severe sepsis. Int J Immunogenet 2008;35: 279–85.

Bone RC Balk RA Cerra FB . Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101: 1644–55.

Cohen J . The immunopathogenesis of sepsis. Nature 2002;420: 885–91.

Khamsi R . Execution of sepsis trials needs an overhaul, experts say. Nat Med 2012;18: 998.

The International Meningococcal Genetics Consortium: Genome-wide Association Study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nature Genetics 2010;42: 772–76.

Gordon AC Umeer W Hansen TK . Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock 2006;25: 88–93.

Arcaroli J Fessler MB Edward A . Genetic polymorphisms and sepsis. Shock 2005;24: 300–12.

Angus DC Marrie TJ Obrosky DS . Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteria. Am J Respir Crit Care Med 2002;166: 717–23.

Idaghdour Y Storey JD Jadallah SJ Gibson G . A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan Amazighs. PLoS Genet 2008;4: e1000052.

Fairfax BP Makino S Radhakrishnan J . Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nat Genetics 2012;44: 502–10.

Cepkova M Kapur V Ren X . Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury. Chest 2007;132: 836–42.

Nuckton TJ Alonso JA Kallet RH . Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome. N Engl J Med 2002;346: 1281–86.

Raurich JM Vilar M Colomar A . Prognostic value of the pulmonary dead-space fraction during the early and intermediate phases of acute respiratory distress syndrome. Respir Care 2010;55: 282–87.

Radford EP Jr . Ventilation standards for use in artificial respiration. J Appl Physiol 1955;7: 451–60.

Sinha P Fauvel NJ Singh S . Ventilatory ratio: a simple bedside measure of ventilation. Br J Anaesthesia 2009;102: 692–97.

Bersten AD Edibam C Hunt T . Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian States. Am J Respir Crit Care Med 2002;165: 443–48.

Chesnut RM Marshall LF Klauber MR . The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993;34: 216–22.

Brain Trauma Foundation. Guidelines for the management of severe traumatic brain injury. J Neurotrauma 2007;24: S1–S95.

Lecky F Woodford M Yates DW . Trends in trauma care in England and Wales 1989–97. UK Trauma Audit and Research Network. Lancet 2000;355: 1771–75.

Harrison DA Welch CA Eddleston JM . The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database. Crit Care 2006;10: R42.

Hunter P . Sepsis under siege: a new understanding of sepsis might lead to the development of therapies to treat septic shock. EMBO Rep 2006;7: 667–69.

Angus DC . Drotrecogin alfa (activated) … a sad final fizzle to a roller-coaster party. Crit Care 2012;16: 107.

Boomer JS . Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011;306: 2594–605.

Kroca M Tärnvik A Sjöstedt A . The proportion of circulating γδ T cells increases after the first week of onset of tularaemia and remains elevated for more than a year. Clin Exp Immunol 2000;120: 280–84.

Hotchkiss RS Swanson PE Freeman BD . Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999;27: 1230–51.

Noble JS MacKirdy FN Donaldson SI Howie JC . Renal and respiratory failure in Scottish ICUs? Anaesthesia 2001; 56: 124–29.

Singer M De Santis V Vitale D Jeffcoate W . Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Lancet 2004;364: 545–48.

Weinberg ED . Iron withholding: a defense against infection and neoplasia. Physiol Rev 1984;64: 65–102.

Weinberg ED . Iron availability and infection? Biochim Biophys Acta 2009; 1790: 600–05.

Gabay C Kushner I . Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999;340: 448–54.

Vander Heiden MG Cantley LC Thompson CB . Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009;324: 1029–33.

Williams GC Nesse RM . The Dawn of Darwinian Medicine. Q Rev Biol 1991;66: 1–22.

Hébert PC Wells M Tweeddale C . Does transfusion practice affect mortality in critically ill patients? Transfusion Requirements in Critical Care (TRICC) Investigators and the Canadian Critical Care Trials Group. Am J Respir Crit Care Med 1997;155: 1618–23.

Zarychanski R Houston DS . Anaemia of chronic disease: a harmful disorder or an adaptive, beneficial response? CMAJ 2008;179: 333–37.

Schaible UE Kaufmann SHE . Iron and microbial infection. Nat Rev Microbiol 2004;2: 946–53.

Lieu PT Heiskala M Peterson PA Yang Y . The roles of iron in health and disease. Mol Aspects Med 2001;22: 1–87.

Kluger MJ Rothenburg BA . Fever and reduced iron: their interaction as a host defense response to bacterial infection. Science 1979;203: 374–76.

LeGrand EK Alcock J . Turning up the heat: immune brinksmanship in the acute-phase response. Q Rev Biol 2012;87: 3–18.

Kluger MJ Ringler DH Anver MR . Fever and survival. Science 1975;188: 166–68.

Williams GC Nesse RM . Evolution and Healing: The New Science of Darwinian Medicine, 1st Edition, New York: Times Books, 1995.

Brenner DJ Hall EJ . Computed tomography – an increasing source of radiation exposure. N Engl J Med 2007;357: 2277–84.

Hirano LA . Clinical yield of computed tomography brain scans in older general medical patients. J Am Geriatrics Soc 2006;54: 587–92.

Salerno D . The role of head computer tomographic scans on the management of MICU patients with neurological dysfunction. J Intensive Care Med 2009;24: 372–75.