This flawed meta-analysis suggests that in critically ill patients with acute kidney injury (AKI) there is no difference in mortality or renal recovery when comparing high intensity continuous renal replacement therapy (CRRT) or intermittent haemodialysis (IHD) (effluent flow rate 35–48 mL/kg/hr or equivalent) vs lower intensity CRRT or IHD (effluent flow rate 20–25 mL/kg/hr or equivalent) strategies.
Level of evidence: 1− (Meta-analysis with a high risk of bias)
References
1.
The RENAL replacement therapy study investigators. Intensity of renal-replacement therapy in critically ill patients. N Engl J Med2009;361: 1627–38.
