ICS Medal and Research Abstract Presentations

Vincent JL . Nosocomial infection in adult intensive-care units. Lancet 2003;361: 2068–77.

EORTC International Antimicrobial Therapy Project Group. Three antibiotic regimens in the treatment of infections in febrile granulocytopenic patients with cancer. J Infect Dis 1978;137: 14–29.

Torres A Rello J . Update in community-acquired and nosocomial pneumonia. 2009. Am J Respir Crit Care Med 2010;181: 782–87.

Adibconquy M Cavaillon J . Stress molecules in sepsis and systemic inflammatory response syndrome. FEBS Lett 2007;581: 3723–33.

Huber-Lang MS Younkin EM Sarma JV . Complement-induced impairment of innate immunity during sepsis. J Immunol 2002;169: 3223–31.

Flierl MA Perl M Rittirsch D . The role of C5a in the innate immune response after experimental blunt chest trauma. Shock 2007;29: 25–31.

Oppermann M Götze O . Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors. Immunology 1994;82: 516–21.

Morris A Conway Kefala K Wilkinson T . C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med 2009;180: 19–28.

Döcke WD Randow F Syrbe U . Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat Med 1997;3: 678–81.

Venet F Chung C-S Kherouf H . Increased circulating regulatory T cells contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 2009;35: 678–86.

Morris A Conway Kefala K Wilkinson TS . Diagnostic importance of pulmonary interleukin-1 beta and interleukin-8 in ventilator-associated pneumonia. Thorax 2010;65: 201–07.

Morris A Conway Kefala K O'Kane C . Ventilator-associated pneumonia is characterised by elevated neutrophil proteases. (Abstract (oral presentation), ICS State of the Art Meeting 2009). JICS 2010;11: 58–59.

Morris A Conway Rossi AG Walsh TS Simpson AJ . C5a drives phagocytic dysfunction via a PI3K delta-dependent inhibition of actin polymerization. (Abstract, ICS State of the Art Meeting 2009). JICS 2010;11: 61.

Morris A Conway Rossi AG Walsh TS Simpson AJ . Inhibition of Rho-A by C5a leads to defective neutrophil phagocytosis in critically ill patients. (Abstract (oral presentation), ESICM Annual Congress 2010). Intensive Care Med in press.

Morris A Conway Antonelli J Brittan M . C5a mediated neutrophil dysfunction precedes and predicts nosocomial infection in critical illness. (Abstract, ESICM Annual Congress 2010). Intensive Care Med in press.

Caille V Chiche J-D Nciri N . Histocompatibility leukocyte antigen-D related expression is specifically altered and predicts mortality in septic shock but not in other causes of shock. Shock 2004;22: 521–26.

Morris A Conway Brittan M Antonelli J . Immuno-suppressive regulatory (CD4⁺CD25⁺FOXP3⁺) T-cells are elevated in septic and non-septic critical illness. Abstract submitted for ICS State of the Art Meeting 2010.

Morris A Conway Brittan M Antonelli J . Combined immuno-phenotyping of neutrophils, monocytes and T-cells enables accurate prediction of the risk of nosocomial infection. Abstract submitted for ICS State of the Art Meeting 2010.

Naeije R and Brimioulle S . Physiology in medicine: importance of hypoxic pulmonary vasoconstriction in maintaining arterial oxygenation during acute respiratory failure. Crit Care 2001;5: 67–71.

Senturk M . New concepts of the management of one-lung ventilation. Curr Opin Anaesthesiol 2006;19: 1–4.

Barbera JA Peinado VI Santos S . Pulmonary hypertension in chronic obstructive pulmonary disease. Eur Respir J 2003;21: 892–905.

Chaouat A Bugnet AS Kadaoui N . Severe pulmonary hypertension and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005;172: 189–94.

McLaughlin VV and McGoon MD . Pulmonary arterial hypertension. Circulation 2006;114: 1417–31.

Smith TG Robbins PA Ratcliffe PJ . The human side of hypoxia-inducible factor. Br J Haematol 2008;141: 325–34.

Smith TG Brooks JT Balanos GM . Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med 2006;3: 1178–85.

Smith TG Brooks JT Balanos GM . Mutation of the von Hippel-Lindau gene alters human cardiopulmonary physiology. In: Integration in Respiratory Control - from Genes to Systems. Poulin MJ and Wilson RJ , Eds. 2008, Springer Publishers: New York.

Smith TG Bishop T Carmeliet P . The acute hypoxic ventilatory response is augmented in PHD2-deficient mice. Am J Resp Crit Care Med 2008;177: A270.

Smith TG Balanos GM Croft QP . The increase in pulmonary arterial pressure caused by hypoxia depends on iron status. J Physiol 2008;586: 5999–6005.

Smith TG Talbot NP Privat C . Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. JAMA 2009;302: 1444–50.

Joyner MJ and Johnson BD . Iron lung? New ideas about hypoxic pulmonary vasoconstriction. J Physiol 2008;586: 5837–38.

Rodriguez RM Corwin HL Gettinger A . Nutritional deficiencies and blunted erythropoietin response as causes of the anemia of critical illness? J Crit Care 2001; 16: 36–41.

Munoz M Romero A Morales M . Iron metabolism, inflammation and anemia in critically ill patients. A cross-sectional study. Nutr Hosp 2005;20: 115–20.

Smith TG Talbot NP . Prolyl hydroxylases and therapeutics. Antioxid Redox Signal 2010;12: 431–33.

Nagel S Talbot NP Mecinovic J Smith TG . Therapeutic manipulation of the HIF hydroxylases. Antioxid Redox Signal 2010;12: 481–501.

Angus DC Linde-Zwirble WT Lidicker J . Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29: 1303–10.

Brun-Buisson C . The epidemiology of the systemic inflammatory response. Intensive Care Med 2000;26 Suppl 1:S64–74.

Martin GS Mannino DM Eaton S . The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003;348: 1546–54.

Bone RC Balk RA Cerra FB . Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101: 1644–55.

MacCallum NS Gordon SE Quinlan GJ . Abstract 23: The Systemic Inflammatory Response Syndrome Following Cardiac Surgery. Circulation 2007;116 (16_MeetingAbstracts):II_928-.

Brun-Buisson C Meshaka P Pinton P . EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med 2004;30: 580–88.

Padkin A Goldfrad C Brady AR . Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med 2003;31: 2332–38.

Das UN . Critical advances in septicemia and septic shock. Crit Care 2000;4: 290–96.

Marshall JC . Neutrophils in the pathogenesis of sepsis. Crit Care Med 2005;33(12 Suppl):S502–5.

MacCallum NS Quinlan GJ Evans TW . The role of neutrophil-derived myeloperoxidase in organ dysfunction and sepsis. In: Vincent JL , ed. Yearbook of Intensive Care and Emergency Medicine: Springer: 2007;173–78.

Weiss SJ Lampert MB Test ST . Long-lived oxidants generated by human neutrophils: characterization and bioactivity. Science 1983;222: 625–28.

Pullar JM Vissers MC Winterbourn CC . Living with a killer: the effects of hypochlorous acid on mammalian cells. IUBMB Life 2000;50: 259–66.

Vissers MC Pullar JM Hampton MB . Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells. Biochem J 1999;344 Pt 2: 443–49.

Griffin SV Chapman PT Lianos EA . The inhibition of myeloperoxidase by ceruloplasmin can be reversed by anti-myeloperoxidase antibodies. Kidney Int 1999;55: 917–25.

Segelmark M Persson B Hellmark T . Binding and inhibition of myeloperoxidase (MPO): a major function of ceruloplasmin? Clin Exp Immunol 1997;108: 167–74.

Baker CS Evans TW Haslam PL . Measurement of ceruloplasmin in the lungs of patients with acute respiratory distress syndrome: is plasma or local production the major source? Respiration 2000;67: 533–38.

Festa M Mumby S Nadel S . Antioxidant protection against iron in children with meningococcal sepsis. Crit Care Med 2002;30: 1623–29.

Gutteridge JM Quinlan GJ Mumby S . Primary plasma antioxidants in adult respiratory distress syndrome patients: changes in iron-oxidizing, iron-binding, and free radical-scavenging proteins. J Lab Clin Med 1994;124: 263–73.

Pepper JR Mumby S Gutteridge JM . Sequential oxidative damage, and changes in iron-binding and iron-oxidising plasma antioxidants during cardiopulmonary bypass surgery. Free Radic Res 1994;21: 377–85.

Vincent JL Moreno R Takala J . The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996;22: 707–10.

Peroxidase activity of hemoproteins released into plasma as sources of oxidative stress in sepsis: a preliminary report. A60. Annual Congress Society of Critical Care Medicine; 2007; Orlando, FL, USA. SCCM.

Winterbourn CC Kettle AJ . Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radic Biol Med 2000;29: 403–09.

Claesson R Karlsson M Zhang Y . Relative role of chloramines, hypochlorous acid, and proteases in the activation of human polymorphonuclear leukocyte collagenase. J Leukoc Biol 1996;60: 598–602.

Arnhold J . Properties, functions, and secretion of human myeloperoxidase. Biochemistry (Mosc) 2004;69: 4–9.

Eiserich JP Baldus S Brennan ML . Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science 2002;296: 2391–94.

Midwinter RG Vissers MC Winterbourn CC . Hypochlorous acid stimulation of the mitogenactivated protein kinase pathway enhances cell survival. Arch Biochem Biophys 2001;394: 13–20.

Schoonbroodt S Legrand-Poels S Best-Belpomme M . Activation of the NF-kappaB transcription factor in a T-lymphocytic cell line by hypochlorous acid. Biochem J 1997;321 (Pt 3):777–85.

Schildknecht S Ullrich V . Peroxynitrite as regulator of vascular prostanoid synthesis. Arch Biochem Biophys 2009;484: 183–89.

Evans TJ Buttery LD Carpenter A . Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria. Proc Natl Acad Sci USA 1996;93: 9553–58.

Sengelov H Kjeldsen L Borregaard N . Control of exocytosis in early neutrophil activation. J Immunol 1993;150: 1535–43.

Marchetti C Patriarca P Solero GP . Genetic characterization of myeloperoxidase deficiency in Italy. Hum Mutat 2004;23: 496–505.

Nauseef WM Root RK Malech HL . Biochemical and immunologic analysis of hereditary myeloperoxidase deficiency. J Clin Invest 1983;71: 1297–307.

Galijasevic S Maitra D Lu T . Myeloperoxidase interaction with peroxynitrite: chloride deficiency and heme depletion. Free Radic Biol Med 2009; In Press, Corrected Proof.

Chapman AL Hampton MB Senthilmohan R . Chlorination of bacterial and neutrophil proteins during phagocytosis and killing of Staphylococcus aureus. J Biol Chem 2002;277: 9757–62.

Zhang R Shen Z Nauseef WM . Defects in leukocyte-mediated initiation of lipid peroxidation in plasma as studied in myeloperoxidase-deficient subjects: systematic identification of multiple endogenous diffusible substrates for myeloperoxidase in plasma. Blood 2002;99: 1802–10.

Park YS Suzuki K Mumby S . Antioxidant binding of caeruloplasmin to myeloperoxidase: myeloperoxidase is inhibited, but oxidase, peroxidase and immunoreactive properties of caeruloplasmin remain intact. Free Radic Res 2000;33: 261–65.

Qian M Eaton JW Wolff SP . Cyanate-mediated inhibition of neutrophil myeloperoxidase activity. Biochem J 1997;326 (Pt 1):159–66.

Andrews PC Krinsky NI . A kinetic analysis of the interaction of human myeloperoxidase with hydrogen peroxide, chloride ions, and protons. J Biol Chem 1982;257: 13240–45.

Winterbourn CC . Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acid. Toxicology 2002;181–82: 223–27.

Pascual C Karzai W Meier-Hellmann A . A controlled study of leukocyte activation in septic patients. Intensive Care Med 1997;23: 743–48.

Dowdy DW Eid MP Sedrakyan A . Quality of life in adult survivors of critical illness: a systematic review of the literature. Intensive Care Med 2005;31: 611–20.

Jackson JC Hart RP Gordon SM . Post-traumatic stress disorder and post-traumatic stress symptoms following critical illness in medical intensive care unit patients: assessing the magnitude of the problem. Crit Care 2007;11: R27.

Granberg A Engberg IB Lundberg D . Patients' experience of being critically ill or severely injured and cared for in an intensive care unit in relation to the ICU syndrome. Part 1. Intensive Crit Care Nursing 1998;14: 294–307.

National Institute for Health and Clinical Excellence. Clinical Guideline 83: Rehabilitation after critical illness. NICE 2009.

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Ware JE Sherbourne CD . The MOS 36-item short-form health survey(SF-36). 1. Conceptual framework and item selection. Medical Care 1992;6: 473–83.

Pearse RM Harrison DA James P . Identification and characterisation of the high-risk surgical population in the United Kingdom. Crit Care 2006;10: R81.

Khuri SF Henderson WG DePalma RG . Determinants of long-term survival after major surgery and the adverse effect of postoperative complications. Ann Surg 2005;242: 326–41; discussion 341–23.

Jhanji S Pearse RM . The use of early intervention to prevent postoperative complications. Curr Opin Crit Care 2009;15: 349–54.

Vignali A Gianotti L Braga M . Altered microperfusion at the rectal stump is predictive for rectal anastomotic leak. Dis Colon Rectum 2000;43: 76–82.

Miyazaki T Kuwano H Kato H . Predictive value of blood flow in the gastric tube in anastomotic insufficiency after thoracic esophagectomy. World J Surg 2002;26: 1319–23.

Pearse R Dawson D Fawcett J . Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]. Crit Care 2005;9: R687–693.

Wilson J Woods I Fawcett J . Reducing the risk of major elective surgery: randomised controlled trial of preoperative optimisation of oxygen delivery? BMJ 1999; 318: 1099–103.

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De Backer D Creteur J Preiser JC . Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002;166: 98–104.

Rivers E Nguyen B Havstad S . Early goal-directed therapy in the treatment of severe sepsis and septic shock? N Engl J Med 2001; 345: 1368–77.

Landry DW Oliver JA . The pathogenesis of vasodilatory shock. N Engl J Med 2001;345: 588–95.

Dellinger RP Levy MM Carlet JM . Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008? Crit Care Med 2008; 36: 296–27.

Brealey D Brand M Hargreaves I . Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002;360: 219–23.

Crouser ED . Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion 2004;4: 729–41.

Brealey D Karyampudi S Jacques TS . Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure? Am J Physiol Regul Integr Comp Physiol 2004; 286: R491–497.

Callahan LA Supinski GS . Sepsis induces diaphragm electron transport chain dysfunction and protein depletion. Am J Respir Crit Care Med 2005;172: 861–68.

Lanone S Taillé C Boczkowski J . Diaphragmatic fatigue during sepsis and septic shock? Intensive Care Med 2005; 31: 1611–17.

Duchen MR . Mitochondria in health and disease: perspectives on a new mitochondrial biology. Mol Aspects Med 2004;25: 365–451.

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Brown GC . Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim Biophys Acta 2001;1504: 46–57.

Haden DW Suliman HB Carraway MS . Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis. Am J Respir Crit Care Med 2007;176: 768–77.

Boczkowski J Lisdero CL Lanone S . Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphragm during endotoxemia. FASEB J 1999;13: 1637–46.

Stevens ED Faulkner JA . The capacity of mdx mouse diaphragm muscle to do oscillatory work. J Physiol 2000;522: 457–66.

Duchen MR Surin A Jacobson J . Imaging mitochondrial function in intact cells. Meth Enzymol 2003;361: 353–89.

Parker N Affourtit C Vidal-Puig A . Energization-dependant endogenous activation of proton conductance in skeletal muscle mitochondria. Biochem J 2008;412: 131–39.

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Bota D Peres Lopes Ferreira F Melot C . Body temperature alterations in the critically ill. Intensive Care Med 2004;30: 811–16.

Callahan LA Stofan DA Szweda LI . Free radicals alter maximal diaphragmatic mitochondrial oxygen consumption in endotoxin-induced sepsis. Free Radic Biol Med 2001;30: 129–38.

Friedrich O . Critical illness myopathy: what is happening? Curr Opin Clin Nutr Metab Care 2006;9: 403–09.

Zink W Kaess M Hofer S . Alterations in intracellular Ca2+-homeostasis of skeletal muscle fibers during sepsis*. Critical Care Med 2008;36: 1559–63.

Morris A Conway Kefala K Wilkinson TS . C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med 2009;180: 19–28.

Caille V Chiche J-D Nciri N . Histocompatibility leukocyte antigen-D related expression is specifically altered and predicts mortality in septic shock but not in other causes of shock. Shock 2004;22: 521–26.

Hebert PC Wells G Blajchman MA . A multicentre, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999;340: 409–17.

Vincent JL Baron JF Reinhart K . Anemia and blood transfusion in critically ill patients. JAMA 2002;288: 1499–507.

Corwin HL Gettinger A Pearl RG . The CRIT Study: Anemia and blood transfusion in the critically ill – Current clinical practice in the United States. Crit Care Med 2004;32: 39–52.

Sakr Y Lobo S Knuepfer S . Anemia and blood transfusion in a surgical intensive care unit. Crit Care 2010;14: R92.

Walsh TS Stanworth SJ Prescott RJ . Prevalence, management and outcomes of critically ill patients with prothrombin time prolongation in United Kingdom intensive care units. Crit Care Med 2010; in press.

Ferreira FL Bota DP . Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001;285: 1754–58.

Vincent JL Sakr Y Sprung C . Are blood transfusions associated with greater mortality rates? Anesthesiology 2008;108: 31–39.

Sakr Y Lobo S Knuepfer S . Anemia and blood transfusion in a surgical intensive care unit. Crit Care 2010;14: R92.

Walsh TS Stanworth SJ Prescott RJ . Prevalence, management and outcomes of critically ill patients with prothrombin time prolongation in United Kingdom intensive care units. Crit Care Med 2010; In Press.

Walsh TS Saleh E-E-D . Anaemia during critical illness. Bri J Anaesthesia 2006;97: 278–91.

Chant C Wilson G Friedrich JO . Anemia, transfusion and phlebotomy practices in critically ill patients with prolonged ICU length of stay: a cohort study. Crit Care 2006;10: R140.

Welch C Harrison D Short A Rowan K . The increasing burden of alcoholic liver disease on United Kingdom critical care units: secondary analysis of a high quality clinical database. J Health Serv Res Policy 2008;13 (Supp 2): 40–44.

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Azoulay E Pochard F Chevret S Adrie C . Half the family members of intensive care unit patients do not want to share in the decision-making process: a study in 78 French intensive care units. Crit Care Med 2004;32: 1832–38.

Pochard F Azoulay E Chevret S Lemaire F . Symptoms of anxiety and depression in family members of intensive care unit patients: ethical hypothesis regarding decision-making capacity. Crit Care Med 2001;29: 1983–97.

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Sprung CL Woodcock T Sjokvist P . Reason, considerations, difficulties and documentation of end-of-life decisions in European intensive care units: the ETHICUS study. Intensive Care Med 2008;34: 271–77.

Bourdeaux C Brown J . Sodium bicarbonate lowers intracranial pressure after traumatic brain injury. Neurocrit Care 2010;13: 24–28.

Venet F Chung C-S Kherouf H . Increased circulating regulatory T cells contribute to lymphocyte anergy in septic shock patients. Intensive Care Med 2009;35: 678–86.

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