Sedation Management in the ICU: Are We at a Crossroads?

De Jonghe B Cook D Appere-De-Vecchi C . Using and understanding sedation scoring systems: a systematic review. Intensive Care Med 2000;26: 275–85.

Muellejans B López A Cross MH . Remifentanil versus fentanyl for analgesia based sedation to provide patient comfort in the intensive care unit: a randomized, double-blind controlled trial. Crit Care 2004;8: R1–R11.

Park G Lane M Rogers S Bassett P . A comparison of hypnotic and analgesic based sedation in a general intensive care unit. Br J Anaesth 2007;98: 76–82.

Park G . Remifentanil in the ICU: a new approach to patient care. Curr Anaesth Crit Care 2002;13: 313–20.

Stawicki SP . Sedation scales: very useful, very underused. OPUS 12 Scientist 2007;1: 10–12.

Kollef MH Levy NT Ahrens TS . The use of continuous IV sedation is associated with prolongation of mechanical ventilation. Chest 1998;114: 541–48.

Cook DJ Walter SD Cook RJ . Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 1998;129: 433–40.

Meade MO Cook DJ Kemerman P Bernard G . How to use articles about harm: the relationship between high tidal volumes, ventilating pressure and ventilator-induced lung injury. Crit Care Med 1997;25: 1915–22.

Sessler CN Grap MJ Ramsay MA . Evaluating and monitoring analgesia and sedation in the intensive care unit. Crit Care 2008;12 Suppl 3:S2.

Tonner PH Weiler N Paris A Scholz J . Sedation and analgesia in the intensive care unit. Curr Opin Anaesthesiol 2003;16: 113–21.

Ramsay MAE . Intensive care: problems of over- and undersedation. Ballière's Clin Anaesthesiol 2000;14: 419–32.

Sessler CN Varney K . Patient-focused sedation and analgesia in the ICU. Chest 2008;133: 552–65.

Audit Commission. Critical to success: the place of efficient and effective critical care services within the acute hospital. London: Audit Commission. 1999.

Wunsch H Harrison D Collange O . World resources in Critical Care Study: a survey of critical care research and resources in eight countries. Crit Care 2007;11(Suppl 2): P506.

Gainsbury S . Crunch time: coming to terms with funding cuts. Health Service J 2009;119: 10–11.

Kress JP Pohlman AS O'Connor MF Hall JB . Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342: 1471–77.

NHS Modernisation Agency. 10 high impact changes for service improvement and delivery. A guide for NHS leaders. London: Department of Health. 2004.

Bauer C Kreuer S Ketter R . Remifentanil-propofol versus fentanyl-midazolam combinations for intracranial surgery: influence of anaesthesia technique and intensive sedation on ventilation times and duration of stay in the ICU. Anaesthesist 2007;56: 128–32.

Ender J Borger MA Scholz M . Cardiac surgery fast-track treatment in a postanesthetic care unit: six-month results of the Leipzig Fast-track Concept. Anesthesiology 2008;109: 61–66.

Muellejans B Matthey T Scholpp J Schill M . Sedation in the intensive care unit with remifentanil/propofol versus midazolam/fentanyl: a randomised, open-label pharmacoeconomic trial. Crit Care 2006;10: R91.