ICS Medal Winners and Research Abstract Presentations

The Irish Critical Care Trials Group. Acute lung injury and the acute respiratory distress syndrome in Ireland: a prospective audit of epidemiology and management. Crit Care 2008;12: R30.

Falagas ME Makris GC Matthaiou DK Rafailidis PI . Statins for infection and sepsis: a systematic review of the clinical evidence. J Antimicrob Chemother 2008;61: 774–85.

Craig T O'Kane C McAuley D . Potential mechanisms by which statins modulate pathogenic mechanisms important in the development of acute lung injury. 27th Yearbook of Intensive Care and Emergency Medicine ed. Berlin: Springer-Verlag; 2007.

Shyamsundar M McKeown STW O'Kane CM Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am J Respir Crit Care Med 2009;179: 1107–14.

Craig T Duffy M Shyamsundar M Extravascular lung water indexed to predicted body weight is a novel predictor of ICU mortality in patients with acute lung injury. Crit Care Med in press.

O'Kane C McKeown S Perkins G Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome. Crit Care Med 2009;37: 2242–49.

Verma S Anderson T . Fundamentals of endothelial function for the clinical cardiologist. Circulation 2002;105: 546–49.

Siegel G Malsten M . The role of the endothelium in inflammation and tumour metastasis. Int J Microcirc Clin Exp 1997;17: 257–72.

Gosling P Brudney S McGrath L Mortality prediction at admission to intensive care: A comparison of microalbuminuria with acute physiology scores after 24 hours. Crit Care Med 2003;31: 98–103.

Trepels T Zeiher A Fichtlscherer S . The endothelium and inflammation. Endothelium 2006;13: 423–29.

Ware L Conner E Matthay M . von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Crit Care Med 2001;29: 2325–31.

Kayal S Jais J Aguinin N . Elevated circulating E-selectin, intercellular adhesion molrcule-1, and von Willebrand Factor in patients with severe infection Am J Resp Crit Care Med 1998;157: 776–84.

O'Rourke M Kim M Adji A Use of arterial transfer function for the derivation of aortic waveform characteristics. J Hypertens 2004;22: 431–34.

Nichols W . Clinical measurement or arterial stiffness obtained from noninvasive pressure waveforms. Am J Hypertension 2005;18: 3S–10S.

Wilkinson I Hall I MacCallum H Pulse-wave analysis: Clinical evaluation of a noninvasive, widely applicable method for assessing endothelial function. Arterioscle Thromb Vasc Biol 2002;22: 147–52.

Norwood M Bown M Sayers R . Ischaemia-reperfusion injury and regional inflammatory responses in abdominal aortic aneurysm repair. Eur J Vasc Endovasc Surg 2004;28: 234–45.

Kraus MF Susmaras T Caughlin BP White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. Brain 2007;130: 2508–19.

Niogi SN Mukherjee P Ghajar J Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3T diffusion tensor imaging study of mild traumatic brain injury. Am J Neuroradiol 2008;131: 3209–21.

Rutgers DR Toulgoat F Cazejust J White matter abnormalities in mild traumatic brain injury: a diffusion tensor imaging study. Am J Neuroradiol 2008;29: 514–19.

Sidaros A Engberg AW Sidaros K Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study. Brain 2007;131: 559–72.

Xu J Rasmussen IA Lagopoulos J Haberg A . Diffuse axonal injury in severe traumatic brain injury visualized using high-resolution diffusion tensor imaging. J Neurotrauma 2007;24: 753–65.

Bendlin BB Ries ML Lazar M Longitudinal changes in patients with traumatic brain injury assessed with diffusion-tensor and volumetric imaging. Neuroimage 2008;42: 503–14.

Greenberg G Mikulis DJ Ng K Use of diffusion tensor imaging to examine subacute white matter injury progression in moderate to severe traumatic brain injury. Arch Phys Med Rehabil 2008;89: S45–50.

Newcombe VFJ Williams GB Abate MG Pathophysiological changes in pericontusional tissue post traumatic brain injury: a diffusion tensor imaging study (Abstract, National Neurotrauma Society Symposium 2007). J Neurotrauma 2007;7: 1260.

Newcombe VFJ Williams GB Abate MG Pathophysiological changes in pericontusional tissue post traumatic brain injury (Abstract, International Society for Magnetic Resonance Medicine Meeting 2008) Proc Intl Soc Mag Reson Med. 2008.

Menon DK Coles JP Gupta AK Diffusion limited oxygen delivery following head injury. Crit Care Med 2004;32: 1384–90.

Menon DK . Procrustes, the traumatic penumbra, and perfusion pressure targets in closed head injury. Anesthesiology 2003;98: 805–07.

Newcombe VFJ Menon DK . Diffusion and perfusion weighted imaging in traumatic brain injury. In: Gillard JH Waldman A Barker P , eds. Clinical MR Neuroimaging: Cambridge University Press, in Press.

Newcombe VFJ Williams GB Nortje J Analysis of acute traumatic axonal injury using diffusion tensor imaging. Br J Neurosurg 2007;21: 340–48.

Newcombe VFJ Nortje J Bradley PG Diffusion tensor eigenvalue analysis in acute severe head trauma (Abstract, National Neurotrauma Society Symposium 2006). J Neurotrauma 2006;26: 985.

Newcombe VFJ Williams GB Nortje J Diffusivity behaves differently in grey and white matter post acute neurotrauma: a diffusion tensor imaging study. (Abstract (oral presentation)), Intracranial Pressure 2007;OS8-1.

Newcombe VFJ Williams GB Nortje J Concordant biology underlies discordant imaging findings: diffusivity behaves differently in grey and white matter post acute neurotrauma. Acta Neurochir Suppl 2008;102: 247–51.

Newcombe VFJ Chatfield D Outtrim JG Mapping traumatic axonal injury with diffusion tensor imaging: correlations with functional outcome (Abstract, Joint Sympoiusm National and International Neurotrauma Societies 2009). J Neurotrauma 2009;8: A68.

Newcombe VFJ Chatfield D Outtrim JG Mapping traumatic axonal injury using diffusion tensor imaging: correlations with functional outcome. (Abstract, International Society for Magnetic Resonance Medicine Annual Meeting 2009). Proc Intl Soc Mag Reson Med 2009;642.

Sherbondy A Akers D Mackenzie R Exploring connectivity of the brain's white matter with dynamic queries. IEEE Trans Vis Comput Graph 2005;11: 419–30.

Newcombe VFJ Outtrim JG Chatfield D Parcellating disconnectivity: understanding the white matter abnromalities associated with neurocognitive deficits in traumatic brain injury (Abstract, Joint Symposium of the National and International Neurotrauma Societies 2009). J Neurotrauma 2009;26: A20.

Chastre J Fagon J-Y . Ventilator-associated pneumonia. Am J Respir Crit Care Med 2002;65: 867–903.

Morris A Conway Kefala K Wilkinson TS C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med 2009;180: 19–28.

Academy of Medical Royal Colleges, A code of practice for the diagnosis and confirmation of death. Academy of Medical Royal Colleges 2008 (page 14) http://www.aomrc.org.uk/aomrc/admin/reports/docs/DofD-final.pdf.

Hughes M Context-sensitive half time in multicompartment pharmacokinetic models for intravenous anaesthetic drugs. Anesthesiology 1992;76: 334–41.

Sasada M Smith S . Drugs in Anaesthesia & Intensive Care 2nd edition. Oxford Medical Publications. 1997.

Coles J Evidence for selective neuronal loss following clinical head injury (abstract). J Neurotrauma 2009;26: A2–A101.

Pearse Crit Care 2005;9: R687–93.

Jhanji Intensive Care Med 2009;35: 671–71.

Tang BM McLean AS Dawes IW Gene-expression profiling of peripheral blood mononuclear cells in sepsis. Crit Care Med 2009;37: 882–88.

Wong HR Cvijanovich N Allen GL Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum. Crit Care Med 2009;37: 1558–66.

Morris A Conway Kefala K Wilkinson TS C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med 2009;180: 19–28.

Huber-Lang M Younkin EM Sarma VJ Complement-induced impairment of innate immunity during sepsis. J Immunol 2002;169: 3223–31.

Morris A Conway Kefala K Wilkinson TS C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med 2009;180: 19–28.

Russell JA Walley KR Singer J Gordon AC Vasopressin versus norepinephrine infusion in patients with septic shock. New Engl J Med 2008;358: 877–87.

Orlov D O'Farrell R McCluskey SA The clinical utility of an index of global oxygenation for guiding red blood cell transfusion in cardiac surgery. Transfusion 2009;49: 682–8.

Herbert PC Yetisir E Martin C . Is a low transfusion threshold safe in critically ill patients with cardiovascular disease. Crit Care Med 2001;29: 227–34.

Michael J . In pursuit of meaningful learning. Adv Physiol Educ 2001;25: 145–58.

Swain DP . The water-tower analogy of the cardiovascular system. Adv Physiol Educ 2000; 24: 43–50.

Gamba G . Analogy for explaining intermediate metabolism. Adv Physiol Educ 2003;27: 156–57.

Mythen M . “Oxygen: give and take.” ICS State of the Art Meeting, December 2002.

Cosgrove JF Thomas the Tank Engine and Friends improve the understanding of oxygen delivery and the pathophysiology of hypoxaemia. Anaesthesia 2006;61: 1069–74.

Solomon Four Group Design http://changingminds.org/explanations/research/design/solomon.htm Accessed August 2009.

McGlone MS Forewarning and forearming stereotype-threatened students. Comm Educ 2007;56: 119–33.

Phua J Has mortality from acute respiratory distress syndrome decreased over time? A systematic review. Am J Respir Crit Care Med 2009;179: 220–27.

Hughes M Acute respiratory distress syndrome: an audit of incidence and outcome in Scottish intensive care units. Anaesthesia 2003;58: 838–45.

Brun-Buisson C Epidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study. Intensive Care Med 2004;30: 51–61.

Esteban A Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 2002;287: 345–55.

Xie H Kang J Mills G . Clinical review: The impact of noise on patients' sleep and the effectiveness of noise reduction strategies in intensive care units. Crit Care 2009;13: 208.

Hardin K A . Sleep in the ICU: potential mechanisms and clinical implications. Chest 2009;136: 284–94.

Waters C . Delirium in the intensive care unit: a narrative review of published assessment tools and the relationship between ICU delirium and clinical outcomes. JICS 2008;9: 46–50.

Richards KC O'Sullivan PS Phillips RL . Measurement of sleep in critically ill patients. J Nurs Meas 2000;8: 131–44.

Vandivier RW Henson PM Douglas IS . Burying the Dead. Chest 2006;129: 1673–82.

Bassford C Pettigrew K Park D Aberrant local steroid metabolism in ARDS. Abstract BTS Winter Meeting. 12–12–2007.

Smeritschnig B Jaksch P Kocher A Quality of life after lung-transplantation: a cross-sectional study. J Heart Lung Transplant 2005;24: 474–80.

Hadjiliadis D Steele MP Govert JA Outcome of lung-transplant patients admitted to the medical ICU. Chest 2004;125: 1040–45.

Health Protection Agency. HIV in the United Kingdom: 2008 report. http://www.hpa.org.uk/web/HPAwebFile/HPAweb_C/1227515298354. (8/7/09).

GMC. Consent: patients and doctors making decisions together. http://www.gmc-uk.org/guidance/ethical_guidance/consent_guidance/Consent_guidance.pdf (9/7/09).

The British HIV Association. UK National Guidelines for HIV Testing 2008. http://www.bhiva.org/cms1222621.asp (7/7/09).

Ramlawi B Otu H Rudolph JL Genomic expression pathways associated with brain injury after cardiopulmonary bypass. J Thorac Cardiovasc Surg 2007;134: 996–1005.

Tomic V Russwurm S Moller E Transcriptomic and proteomic patterns of systemic inflammation in on-pump and off-pump coronary artery bypass grafting. Circulation 2005;112: 2912–20.

Nolan J Soar J Eikeland H . The chain of survival. Resuscitation 2006;71: 270–71.

Ecc Committee SaTFotAHA. 2005 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. [reprint in Pediatrics. 2006; 117 (5): e1029–38; PMID: 16651282]. Circulation 2005;112: IV1–203.

Handley AJ Koster R Monsieurs K for European Resuscitation C. European Resuscitation Council Guidelines for Resuscitation 2005. Section 2. Adult basic life support and use of automated external defibrillators.[see comment][erratum appears in Resuscitation 2006;69:351]. Resuscitation 2005;67 Suppl 1:S7–23.

Pickard A Darby M Soar J . Radiological assessment of the adult chest: implications for chest compressions. Resuscitation 2006;71: 387–90.

Shin J Rhee JE Kim K . Is the inter-nipple line the correct hand position for effective chest compression in adult cardiopulmonary resuscitation? Resuscitation 2007;75: 305–10.