A sedation algorithm designed to keep patients at RASS −2 to −3 out-performed daily interruption of sedation, with a reduction in mechanical ventilator days, length of ICU stay, and hospital length of stay.
Level of evidence: 1− (RCT with a high risk of bias)
References
1.
KressJPPohlmanASO'ConnorMFHallJB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. New Engl J Med2000;342: 1471–77.
2.
GirardTDKressJPFuchsBDEfficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled Trial). Lancet2008;371: 126–34.
