Is Selective Decontamination of the Digestive Tract a Solution to the Antimicrobial Resistance Problem in the UK?

Stoutenbeek CP van Saene HKF Miranda DR Zandstra DF . The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients. Intensive Care Med 1984;10: 185–92.

Viviani M Silvestri L van Saene HKF My brother has severe sepsis. Should he receive selective decontamination of the digestive tract (SDD)? Minerva Anestesiol 2008;74: 507.

Rommes JH Spronk PE van der Voort PHJ Richtlijn: Het voorkomen van bacteriéle sterfte tijdens beademing. Neth J Crit Care 2007;10: 1: 38–53.

de Smet AMGA Kluytmans JAJW Cooper BS Decontamination of the digestive tract and oropharynx in ICU patients. New Engl J Med 2009;360: 20–31.

Silvestri L van Saene HKF Casarin A Impact of selective decontamination of the digestive tract on carriage and infection due to Gram-negative and Gram-positive bacteria: a systematic review of randomised controlled trials. Anaesth Intensive Care 2008;36: 324–38.

Silvestri L van Saene HKF Weir I Gullo A . Survival benefit of the full selective digestive decontamination regimen. J Crit Care 2009; doi:10.1016/j.jcrc.2008.11.005.

NHS National Institute for Health and Clinical Excellence. Technical patient safety solutions for ventilator associated pneumonia in adults. NICE/NPSA/2008/PSG 002. www.nice.org.uk/patientsafetypilot.

Bronzwaer SL Buchholz U Kool JL EARSS activities and results: update. Euro Surveill 2001;6: 2–5.

Kuipers JS . Combinations of antimicrobial agents. The in-vitro sensitivity of 100 strains of Pseudomonas aeruginosa to polymyxin B, colistin, carbenicillin, gentamicin and doxycycline and to various combinations of these antibiotics. Archivum Chirurgicum Neerlandicum 1975;27: 257–70.

Mulder JG Wiersma WE Welling GW Low dose oral tobramycin treatment for selective decontamination of the digestive tract: a study in human volunteers. J Antimicrob Chemother 1984;13: 495–504.

van Saene JJM van Saene HKF Tarko-Smit NJ Enterobacteriaceae suppression by three different oral doses of polymyxin E in human volunteers. Epidemiol Infect 1988;100: 407–17.

van Saene JJM Stoutenbeek CP van Saene HKF Reduction of the intestinal endotoxin pool by three different SDD regimens in human volunteers. J Endotoxin Res 1996;3: 337–43.

van Saene HKF Reilly NJ de Silvestre A Antibiotic policies in the intensive care unit. In: van Saene HKF Silvestri L de la Cal MA , eds. Infection Control in the Intensive Care Unit, 2nd, ed. Milan, Italy: Springer Verlag. 2005: 231–46.

Thorburn K Taylor N Saladi SM van Saene HKF . Use of surveillance cultures and enteral vancomycin to control methicillin-resistant Staphylococcus aureus in a paediatric intensive care unit. Clin Microbiol Infect 2006;12: 35–42.

Gaussorgues Ph Salord F Sirodot M Nosocomial bacteremia in patients under mechanical ventilation and receiving beta-inotropic drugs: efficacy of digestive decontamination. Réan Soíns Intens Méd Urg 1991;7: 169–74.

Pugin J Auckenthaler R Lew DP Suter PM . Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia. JAMA 1991;266: 2704–10.

Korinek AM Laisne MJ Nicolas MH Selective decontamination of the digestive tract in neurosurgical intensive care unit patients: A doubleblind, randomised, placebo-controlled study. Crit Care Med 1993;21: 1466–73.

Schardey HM Joosten U Finke U The prevention of anastomotic leakage after total gastrectomy with local decontamination. A prospective, randomised, double-blind, placebo-controlled multicenter trial Ann Surg 1997;225: 172–80.

Bergmans DCJJ Bonten MJM Gaillard CA Prevention of ventilator-associated pneumonia by oral decontamination. A prospective, randomised, double-blind, placebo-controlled study. Am J Respir Crit Care Med 2001;164: 382–88.

Krueger WA Lenhart FP Neeser G Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients. A prospective, stratified, randomised, double-blind, placebo-controlled clinical trial. Am J Respir Crit Care Med 2002;166: 1029–37.

Silvestri L Milanese M Oblach L Enteral vancomycin to control methicillin-resistant Staphylococcus aureus outbreak in mechanically ventilated patients. Am J Infect Control 2002;30: 391–99.

Silvestri L van Saene HKF Milanese M Prevention of MRSA pneumonia by oral vancomycin decontamination: a randomised trial. Eur Respir J 2004;23: 921–26.

Viviani M van Saene HKF Dezzoni R Control of imported and acquired methicillin-resistant Staphylococcus aureus (MRSA) in mechanically ventilated patients: a dose-response study of enteral vancomycin to reduce absolute carriage and infection. Anaesth Intensive Care 2005;33: 361–72.

de la Cal MA Cerda E van Saene HKF Effectiveness and safety of enteral vancomycin to control endemicity of methicillin-resistant Staphylococcus aureus in a medical/surgical intensive care unit. J Hosp Infect 2004;56: 175–83.

Cerda E Abella A de la Cal MA Enteral vancomycin controls methicillin-resistant Staphylococcus aureus endemicity in an intensive care burn unit. Ann Surg 2007;245: 397–407.

Stiefel U Paterson DL Pultz NJ Effect of the increasing use of piperacillin/tazobactam on the incidence of vancomycin-resistant enterococci in four academic medical centers. Infect Control Hosp Epidemiol 2004;25: 580–83.

Salgado CD Gianetta ET Farr BM . Failure to develop vancomycin-resistant Enterococcus with oral vancomycin treatment of Clostridium difficile. Infect Control Hosp Epidemiol 2004;25: 413–17.

D'Agata EMC Venkataraman L de Girolami P Colonisation with broad-spectrum cephalosporin-resistant Gram-negative bacilli in intensive care units during a non-outbreak period: Prevalence, risk factors, and rate of infection. Crit Care Med 1999;27: 1090–95.

Batra R Eziefula AC Wyncoll D Edgeworth J . Throat and rectal swabs may have an important role in MRSA screening of critically ill patients. Intensive Care Med 2008;34: 1703–06.

Walsh B Salzman M Gaunt N Methicillin-resistant Staphylococcus aureus. Lancet 1985;ii: 219–20.

Rimland D Robertson B . Gastrointestinal carriage of methicillin-resistant Staphylococcus aureus. J Clin Microbiol 1986;24: 137–38.

Brady LM Thomson M Palmer MA Successful control of endemic MRSA in a cardiothoracic surgical unit. Med J Aust 1990;152: 240–45.

Shahin R Johnson IL Jamieson F Methicillin-resistant Staphylococcus aureus carriage in a child care centre following a case of disease. Arch Pediatr Adolesc Med 1999;153: 864–68.

Harbarth S Dharan S Liassine N Randomised, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 1994;43: 1412–16.

Wolf SE . The year in burns 2007. Burns 2008;34: 1059–71.

Bastin AJ Ryanna KB . Use of selective decontamination of the digestive tract in United Kingdom intensive care units. Anaesthesia 2009;64: 46–49.

Masterton RG Galloway A French G Guidelines for the management of hospital-acquired pneumonia in the UK: Report of the Working Party on hospital-acquired pneumonia of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother 2008;62: 5–34.

Bion JF Badger I Crosby HA Selective decontamination of the digestive tract reduces Gram-negative pulmonary colonization but not systemic endotoxemia in patients undergoing elective liver transplantation. Crit Care Med 1994;22: 40–49.

Blair P Rowlands BJ Lowry K Selective decontamination of the digestive tract: A stratified, randomized, prospective study in a mixed intensive care unit. Surgery 1991;110: 303–10.

Finch RG Tomlinson P Holliday M Selective decontamination of the digestive tract [SDD] in the prevention of secondary sepsis in a medical/surgical intensive care unit. 17th International Congress of Chemotherapy. Berlin. 1991, Abstract 0474.

Gosney M Martin MV Wright AE . The role of selective decontamination of the digestive tract in acute stroke. Age Ageing 2006;35: 42–47.

Jacobs S Foweraker JE Roberts SE . Effectiveness of selective decontamination of the digestive tract (SDD) in an ICU with a policy encouraging a low gastric pH. Clin Intens Care 1992;3: 52–58.

Rolando N Grimson A Wade J Prospective controlled trial of selective parenteral and enteral antimicrobial regimen in fulminant liver failure. Hepatology 1993;17: 196–201.

Rolando N Wade JJ Stangou A Prospective study comparing the efficacy of prophylactic parenteral antimicrobials, with or without enteral decontamination, in patients with acute liver failure. Liver Transpl Surg 1996;2: 8–13.

Winter R Humphreys H Pick A A controlled trial of selective decontamination of the digestive tract in intensive care and its effect on nosocomial infection. J Antimicrob Chemother 1992;30: 73–87.

Cepada JA Whitehouse T Cooper B Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive care units: prospective two centre study. Lancet 2005;365: 295–304.

Silvestri L Petros AJ Sarginson RE Handwashing in the intensive care unit: a big measure with modest effects. J Hosp Infect 2005;59: 172–79.

Vollaard EJ Clasener HAL . Colonization resistance. Antimicrob Agents Chemother 1994;335: 409–14.

Doberenz DT Templeton M Meacher R . Reduction of ICU acquired MRSA, Acinetobacter and VRE with introduction of SDD. Intensive Care Med 2008;34 (S1):S184.

Abecasis F Kerr S Sarginson RE Comment on: Emergence of multidrug-resistant Gram-negative bacteria during selective decontamination of the digestive tract on an intensive care unit. J Antimicrob Chemother 2007;60: 445.