ICS Research Gold Medal Abstract Presentations

Bennett-Guerrero E Welsby I Dunn TJ Young LR Wahl TA Diers TL The use of a postoperative morbidity survey to evaluate patients with prolonged hospitalisation after routine, moderate-risk, elective surgery. Anesth Analg 1999; 89: 514–9.

Bennett-Guerrero E Panah MH Barclay GR Bodian CA Winfree WJ Andres LA Decreased endotoxin immunity is associated with greater mortality and/or prolonged hospitalisation after surgery. Anesthesiology 2001; 94: 992–8.

Andersen LW Baek L Degn H Lehd J Krasnik M Rasmussen JP . Presence of circulating endotoxins during cardiac operations. J Thorac Cardiovasc Surg 1987; 93: 115–9.

Martinez-Pellus AE Merino P Bru M Canovas J Seller G Sapina J Endogenous endotoxemia of intestinal origin during cardiopulmonary bypass. Role of type of flow and protective effect of selective digestive decontamination. Intensive Care Med 1997; 23: 1251–7.

Rothenburger M Soeparwata R Deng MC Berendes E Schmid C Tjan TD The impact of anti-endotoxin core antibodies on endotoxin and cytokine release and ventilation time after cardiac surgery. J Am Coll Cardiol 2001; 38: 124–30.

Bolke E Jehle PM Storck M Braun C Schams S Steinbach G Endovascular stent-graft placement versus conventional open surgery in infrarenal aortic aneurysm: a prospective study on acute phase response and clinical outcome. Clin Chim Acta 2001; 314: 203–7.

Bolke E Jehle PM Graf M Baier A Wiedeck H Steinbach G Inflammatory response during abdominal and thyroid surgery: a prospective clinical trial on mediator release. Shock 2001; 16: 334–9.

Stephens RC O'Malley CM Frumento RJ Mythen MG Bennett-Guerrero E . Low-dose endotoxin elicits variability in the inflammatory response in healthy volunteers. J Endotoxin Res 2005; 11: 207–12.

Suffredini AF Hochstein HD McMahon FG . Dose-related inflammatory effects of intravenous endotoxin in humans: evaluation of a new clinical lot of Escherichia coli O: 113 endotoxin. J Infectious Dis 1999; 179: 1278–82.

Stephen RCM Dixon GL Rashid M Mythen M . Anti-endotoxin therapies: where are we now? Netherlands J Crit Care 2005; 9: 20–5.

Bennett-Guerrero E Ayuso L Hamilton-Davies C White WD Barclay GR Smith PK Relationship of preoperative antiendotoxin core antibodies and adverse outcomes following cardiac surgery. Jama 1997; 277: 646–50.

Hamilton-Davies C Barclay GR Cardigan RA McDonald SJ Purdy G Machin SJ Relationship between pre-operative endotoxin core antibody levels, gut perfusion and outcome following cardiac valve surgery. Chest 1997; 112: 1189–96.

Mythen MG Barclay GR Purdy G Hamilton-Davies C Mackie IJ Webb AR The role of endotoxin immunity, neutrophil degranulation and contact activation in the pathogenesis of post-operative organ dysfunction. Blood Coagulation Fibrinolysis 1993; 4: 999–1005.

Goldie AS Fearon KC Ross JA Barclay GR Jackson RE Grant IS Natural cytokine antagonists and endogenous antiendotoxin core antibodies in sepsis syndrome. The Sepsis Intervention Group. Jama 1995; 274: 172–7.

Strutz F Heller G Krasemann K Krone B Muller GA . Relationship of antibodies to endotoxin core to mortality in medical patients with sepsis syndrome. Intensive Care Med 1999; 25: 435–44.

Stephens RC Fidler K Wilson P Barclay GR Mythen MG Dixon GL Endotoxin immunity and the development of the systemic inflammatory response syndrome in critically ill children. Intensive Care Med 2006; 32: 286–94.

Stephens RCM Rashid M Dixon G Baxendale H Saunders J Humphries SE and Mythen M . Antibodies to endotoxin core and outcome after 1st time-Coronary Artery Bypass Graft surgery. 9-11-2006. Accepted for presentation at the International Endotoxin and Innate Immunity Society meeting, USA. Ref Type: Conference Proceeding.

Rashid M Stephens R Siva M Grocott M Burdett E Turner D Regional variation in anti-endotoxin core antibody levels in healthy and preoperative surgical populations. Crit Care 2004; 7 (supp 2): 199.

Carcillo J . Searching for the etiology of systemic inflammatory response syndrome: is SIRS occult endotoxemia? Intensive Care Med 2006; 32: 181–4.

Stephens RC Rashid M Dixon GL Baxendale H and Mythen MG . How do levels of antibody against endotoxin core change with time? 2005. European shock society. Ref Type: Conference Proceeding.

Angus DC Birmingham MC Balk RA Scannon PJ Collins D Kruse JA E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomised controlled trial. E5 Study Investigators. Jama 2000; 283: 1723–30.

Anonymous. The French National Registry of HA-1A (Centoxin) in septic shock. A cohort study of 600 patients. The National Committee for the Evaluation of Centoxin. Arch Int Med 1994; 154: 2484–91.

Bone RC Balk RA Fein AM Perl TM Wenzel RP Reines HD A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomised, controlled trial. The E5 Sepsis Study Group. Crit Care Med 1995; 23: 994–1006.

Derkx B Wittes J McCloskey R . Randomized, placebo-controlled trial of HA-1A, a human monoclonal antibody to endotoxin, in children with meningococcal septic shock. European Pediatric Meningococcal Septic Shock Trial Study Group. Clin Infectious Dis 1999; 28: 770–7.

Fisher CJ Jr. Zimmerman J Khazaeli MB Albertson TE Dellinger RP Panacek EA Initial evaluation of human monoclonal anti-lipid A antibody (HA-1A) in patients with sepsis syndrome. Crit Care Med 1990; 18: 1311–5.

Greenberg RN Wilson KM Kunz AY Wedel NI Gorelick KJ . Randomized, double-blind phase II study of anti-endotoxin antibody (E5) as adjuvant therapy in humans with serious gram-negative infections. Progress Clin Biol Res 1991; 367: 179–86.

Greenman RL Schein RM Martin MA Wenzel RP MacIntyre NR Emmanuel G A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group. Jama 1991; 266: 1097–102.

Marra MN Thornton MB Snable JL Wilde CG Scott RW . Endotoxin-binding and -neutralising properties of recombinant bactericidal/permeability-increasing protein and monoclonal antibodies HA-1A and E5. Crit Care Med 1994; 22: 559–65.