Chlorhexidine is an effective cleansing skin-preparation agent and has many user benefits. It has, however, been associated with a number of complications which are highlighted in this paper. All users of chlorhexidine must be aware of these risks and employ insightful use of this chemical.
BodeLG, KluytmansJA, WertheimHF2010Preventing surgical-site infections in nasal carriers of Staphylococcus aureusNew England Journal of Medicine362(1) 9–17
2.
DarouicheRO, WallMJJr, ItaniKM2010Chlorhexidine alcohol versus povidone-iodine for surgical-site antisepsisNew England Journal of Medicine362(1) 18–26
3.
DouwCM, BulstraSK, VandenbrouckeJ, GeesinkRG, VermeulenA1998Clinical and pathological changes in the knee after accidental chlorhexidine irrigation during arthroscopy.Case reports and review of the literature Journal of Bone and Joint Surgery (Br)80(3) 437–40
4.
DukesMN1992Economic costs of adverse drug reactionsPharmacoeconomics1(3) 153–4
5.
GarlandJS, AlexCP, MuellerCD, Cisler-KahillLA1996Local reactions to a chlorhexidine gluconate impregnated antimicrobial dressing in very low birth weight infantsThe Pediatric Infectious Disease Journal15(10) 912–4
6.
IgarashiY, SuzukiJ1985Cochlear ototoxicity of chlorhexidine gluconate in catsArchives of Otorhinolaryngology242(2) 167–76
7.
LimKS, KamPC2008Chlorhexidine –pharmacology and clinical applicationsAnaesthesia and Intensive Care36(4) 502–12
8.
MangramAJ, HoranTC, PearsonML, SilverLC, JarvisWR1999Guideline for prevention of surgical site infection.Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee American Journal of Infection Control27(2) 96–134
9.
MannanK, ChowP, LissauerT, GodambeS2007Mistaken identity of skin cleansing solution leading to extensive chemical burns in an extremely preterm infantActa Paediatrica96(10) 1536–7
10.
MilstoneAM, PassarettiCL, PerlTM2008Chlorhexidine: expanding the armamentarium for infection control and preventionClinical Infectious Diseases46(2) 274–81
11.
MarloweL, MistryRD, CoffinS2010Blood culture contamination rates after skin antisepsis with chlorhexidine gluconate versus povidone-iodine in a pediatric emergency departmentInfection Control and Hospital Epidemiology31(2) 171–6
12.
ReichmanDE, GreenbergJA2009Reducing surgical site infections: a reviewReviews in Obstetrics and Gynecology2(4) 212–21
13.
ReynoldsPR, BanerjeeS, MeekJH2005Alcohol burns in extremely low birthweight infants: still occurring Archives of Disease in Childhood.Fetal and Neonatal Edition90(1) F10
14.
SatoK, KusakaY, SuganumaN, NagasawaS, DeguchiY2004Occupational allergy in medical doctorsJournal of Occupational Health46(2) 165–70