Evidence of the Existence of 2:1 Guest–Host Complexes between Diclofenac and Cyclodextrins in D 2 O Solutions. A 1 H and 13 C NMR Study on Diclofenac/β-Cyclodextrin and Diclofenac/2-Hydroxypropyl-β-cyclodextrin Systems
Free accessResearch articleFirst published online July, 1999
Evidence of the Existence of 2:1 Guest–Host Complexes between Diclofenac and Cyclodextrins in D 2 O Solutions. A 1 H and 13 C NMR Study on Diclofenac/β-Cyclodextrin and Diclofenac/2-Hydroxypropyl-β-cyclodextrin Systems
The interaction of diclofenac sodium salt (DCFNa) and two cyclodextrins, β-cyclodextrin (βCD) and 2-hydroxypropyl-β-cyclodextrin (HPβCD), studied in D2O solution with different NMR techniques (1H, 13C NMR, ROESY experiments, NMR titrations), shows the existence of multiple equilibria involving 1:1 and 2:1 guest–host complexes.
