Free accessResearch articleFirst published online 1999-1
Utility of [( p -Sulfonamidophenyl)azo]malononitrile in the Synthesis of Polyfunctionally Substituted Pyrimidine,Pyrazole,Isoxazole and Pyridazine Derivatives
[(p-Sulfonamidophenyl)azo]malononitrile and/or [(p-sulfonamidophenyl)azo]acrylonitrile derivatives react with various reagents to afford pyrimidine, pyrazole, isooxazole and pyridazine derivatives with interesting biological activities via initial addition to either the cyano or amino group followed by cyclization.
References
1.
MandellG. L., and PetriW. A.Jr., in Goodman & Gillman's The Pharmacological Basis of Therapeutics, 9th edn., McGraw Hill, New York, 1996, pp. 1057–1060 and references therein.
2.
ElnagdiM. H., and Abd AllahS. O., J. Prakt. Chem., 1973, 8, 1009.
3.
ZahranM. A., HassanienA. A., EmamH. A., El-SaidM. Z., and AmmarY. A., Croat. Chem. Acta, 1997, 70, 1039.
4.
HusseinA. M., AtallaA. A., HafizI. S. A., and ElnagdiM. H., J. Heteroatom. Chem., 1997, 8, 29.
5.
Abdel HamidA. O., NegmA. M., and AbbasI. M., J. Prakt. Chem., 1989, 331, 31.
6.
HerolldF., Acta Pol. Pharm., 1985, 42, 263.
7.
SchaferH., GewaldK., and GrunerM., J. Prakt. Chem., 1989, 331, 878.
