This is the first in a series of five papers on the role, remit and function of research ethics committees which are intended to provide for REC members a broad understanding of the most important issues in research ethics and governance. The first considers the rationale for having ethics review by committee at all; seeking to explain why ethics committees, as we currently have them, are so important to the wider system of governing research.
References
1.
MerrittM. Moral conflict in clinical trials. Ethics2005; 115: 306–330.
2.
Shrader-FrechetteKS. Ethics of scientific research. Rowman and Littlefield Publishers, Maryland1994.
3.
EdwardsSJL. Student projects in medicine: a lesson in science and ethics. Accountability in research: policies and quality assurance2009; 16(6): 285.
4.
EdwardsSJLLilfordRJBraunholtzDAJacksonJC. Why ‘underpowered’ trials are not necessarily unethical. The Lancet1997; 350: 804–07.
5.
EdwardsSJL. Moral compromises in clinical trials: response to Maria Merritt. In preparation.
6.
PullmanDWangX. Adaptive designs, informed consent, and the ethics of research. Contemporary clinical trials2001; 22(3): 203–210.
7.
AshcroftR. Equipoise, knowledge and ethics in clinical research and practice. Bioethics1999; 13: 314–326.
8.
MorinKRakatanskyHRiddickFAMorseLJO'BannonJMIIIGoldrichMSRayPWeissMSadeRMSpillmanMA. Managing conflicts of interest in the conduct of clinical trials. JAMA2002; 287: 78–84.
9.
AgatiA. Clinical research trials in the courtroom. In: Clinical Research Law and Compliance Handbook. Ed: SteinerJE. Jones & Bartlett Publishers, 2006.
10.
MorreimEH. Litigation in clinical research: malpractice doctrines versus research realities. J Law Med Ethics2004; 32: 474–484.
11.
ArnesonR. Paternalism, utility and fairness. Reprinted in Mill's on liberty: critical essays. Ed. DworkinG.LanhamMD: Rowman and Littlefield, 1997.
12.
GarrardEDawsonA. What is the role of the REC? Paternalism, inducements and harm in research ethics. Journal of medical ethics2005; 31: 419–423.
EdwardsSJLAshcroftRAKirchinS. Are discrepancies between research ethics committees always morally problematic?Bioethics2004; 18(4): 408–427.
15.
ElliottLHunterD. The experiences of ethics committee members: contradictions between individuals and committees. Journal of medical ethics2008; 34: 489–494.