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Abstract

Objectives

The purpose of this scoping review was to identify which biomarkers for sleep disturbance were the most prevalent and significant in the literature across chronic illnesses.

Methods

A scoping review was conducted, following Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines, to provide a map of the existing literature on the biomarkers of sleep disturbance in adults with chronic illness. Peer-reviewed articles published between 2010–2020 were included if they measured a biomarker and discussed sleep deprivation, disturbance, or dysfunction secondary to a chronic illness.

Results

A total of 21 articles were included and synthesized using data charting. There were 24 different biomarkers identified, most commonly collected through serum. Biomarkers were grouped, then biomarkers and correlations with sleep were identified and mapped.

Discussion

Overall, the most common biomarkers studied were interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), c-reactive protein (CRP), and interleukin-1 beta (IL-1β). Cytokines were the most commonly studied biomarkers, with a majority of studies focusing on pro-inflammatory cytokines. Based on the results of this review, CRP, IL-6, TNF-α, and erythrocyte sedimentation rate (ESR) showed themost significant correlations with sleep across all chronic illnesses. Future research is still needed to identify an ideal biomarker for sleep disturbance that can be used across chronic illnesses.

Keywords

biomarkers sleep disturbance adults chronic illness scoping review

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References

National Center for Chronic Disease Prevention and Health Promotion. Chronic diseases in America, https://www.cdc.gov/chronicdisease/index.htm (2020, accessed 07 August 2020).

Irwin

Sleep and inflammation: partners in sickness and in health. Nat Rev Immunol 2019; 19: 702–715.

Kinnucan

Rubin

Ali

. Sleep and inflammatory bowel disease: exploring the relationship between sleep disturbances and inflammation. Gastroenterol Hepatol 2013; 9: 718–727.

Cashion

Gill

Hawes

, et al. National institutes of health symptom science model sheds light on patient symptoms. Nurs Outlook 2016; 64: 499–506.

Strimbu

Tavel

. What are biomarkers? Curr Opin HIV AIDS 2010; 5: 463–466.

Peters

MDJ

Godfrey

McInerney

, et al. Joanna Briggs institute reviewers’ manual: 2015 edition/supplement. South Australia: Joanna Briggs Institute, 2015.

Tricco

Lillie

Zarin

, et al. PRISMA Extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med 2018; 169: 467–473.

Alt

Sautter

Mace

, et al. Antisomnogenic cytokines, quality of life, and chronic rhinosinusitis: a pilot study. Laryngoscope 2014; 124: E107–E114.

Casida

Davis

Shpakoff

, et al. An exploratory study of the patients’ sleep patterns and inflammatory response following cardiopulmonary bypass (CPB). J Clin Nurs 2014; 23: 2332–2342.

10.

Chen

Cheng

Pan

, et al. Cognitive-behavioral therapy for sleep disturbance decreases inflammatory cytokines and oxidative stress in hemodialysis patients. Kidney Int 2011; 80: 415–422.

11.

Chen

Yin

Zhao

, et al. Elevation of serum TNF-α levels in mild and moderate Alzheimer patients with daytime sleepiness. J Neuroimmunol 2012; 244: 97–102.

12.

Chou

Chao

Chen

, et al. Chemotherapy agents induce tartrate-resistant acid phosphatase 5a contributing to the symptom distress in lung cancer patients. Eur J Pharmacol 2019; 846: 38–48.

13.

Clevenger

Schrepf

Christensen

, et al. Sleep disturbance, cytokines, and fatigue in women with ovarian cancer. Brain Behav Immun 2012; 26: 1037–1044.

14.

Da Estrela

McGrath

Booij

, et al. Heart rate variability, sleep quality, and depression in the context of chronic stress. Ann Behav Med 2020; 55: 155–164.

15.

Duffy

Teknos

Taylor

, et al. Health behaviors predict higher interleukin-6 levels among patients newly diagnosed with head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2013; 22: 374–381.

16.

Gezer

Batmaz

Sariyildiz

, et al. Sleep quality in patients with psoriatic arthritis. Int J Rheum Dis 2017; 20: 1212–1218.

17.

Ghabril

Jackson

Gotur

, et al. Most individuals with advanced cirrhosis have sleep disturbances, which are associated with poor quality of life. Clin Gastroenterol Hepatol 2017; 15: 1271–8.e6.

18.

Heffner

France

Trost

, et al. Chronic low back pain, sleep disturbance, and interleukin-6. Clin J Pain 2011; 27: 35–41.

19.

Xue

, et al. Association of inflammatory cytokines with the symptom cluster of pain, fatigue, depression, and sleep disturbance in Chinese patients with cancer. J Pain Symptom Manage 2017; 54: 843–852.

20.

Kucuksahin

Omma

Ozdemirel

, et al. Incidence of sleep disturbances in patients with familial Mediterranean fever and the relation of sleep quality with disease activity. Int J Rheum Dis 2018; 21: 1849–1856.

21.

Liguori

Nuccetelli

Izzi

, et al. Rapid eye movement sleep disruption and sleep fragmentation are associated with increased orexin-A cerebrospinal-fluid levels in mild cognitive impairment due to Alzheimer’s disease. Neurobiol Aging 2016; 40: 120–126.

22.

Lindqvist

Kaufman

Brundin

, et al. Non-motor symptoms in patients with Parkinson’s disease - correlations with inflammatory cytokines in serum. PLoS One 2012; 7: e47387.

23.

Lopez-Jornet

Cayuela

Tvarijonaviciute

, et al. Oral lichen planus: salival biomarkers cortisol, immunoglobulin A, adiponectin. J Oral Pathol Med 2016; 45: 211–217.

24.

Moon

Schmidt

Smirnova

, et al. Qigong exercise may reduce serum TNF-α levels and improve sleep in people with Parkinson’s disease: a pilot study. Medicines (Basel) 2017; 4: 1–9.

25.

Moore

Voss

Webel

. Sex-based differences in plasma cytokine concentrations and sleep disturbance relationships among people living with HIV. J Assoc Nurses AIDS Care 2020; 31: 249–254.

26.

Nakamura

Schwander

Donnelly

, et al. Exercise and sleep deprivation do not change cytokine expression levels in patients with chronic fatigue syndrome. Clin Vaccine Immunol 2013; 20: 1736–1742.

27.

Nelson

Coe

Juckett

, et al. Sleep quality following hematopoietic stem cell transplantation: longitudinal trajectories and biobehavioral correlates. Bone Marrow Transplant 2014; 49: 1405–1411.

28.

Park

Chung

. Inflammatory cytokines and sleep disturbance in patients with temporomandibular disorders. J Oral Facial Pain Headache 2016; 30: 27–33.

29.

Rockstrom

Chen

Taishi

, et al. Tumor necrosis factor alpha in sleep regulation. Sleep Med Rev 2018; 40: 69–78.

30.

Grandner

Buxton

Jackson

, et al. Extreme sleep durations and increased C-reactive protein: effects of sex and ethnoracial group. Sleep 2013; 36: 769–79E.

31.

De Luca Canto

Pachêco-Pereira

Aydinoz

, et al. Diagnostic capability of biological markers in assessment of obstructive sleep apnea: a systematic review and meta-analysis. J Clin Sleep Med 2015; 11: 27–36.

32.

Irwin

Olmstead

Carroll

. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry 2016; 80: 40–52. Epub 2015 Jun 1. PMID: 26140821; PMCID: PMC4666828.

33.

National Institutes of Health Office of Research on Women’s Health. NIH policy on sex as a biological variable, https://orwh.od.nih.gov/sex-gender/nih-policy-sex-biological-variable (n.d., accessed 07 August 2020).

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Biomarkers of sleep disturbance in adults with chronic illness: A scoping review

Abstract

Objectives

Methods

Results

Discussion

Keywords

Get full access to this article

References

Supplementary Material